Abstract: A noise model is iteratively trained to simulate introduction of noise by a capture device, by use of a denoiser and a training data set of pairs of noisy signals. First and second noisy signals of each pair are independently sampled by the capture device from source information corresponding to the pair. Each iteration of training obtains first and second denoised signals from respective noisy signals, then optimizes at least one loss function which sums first and second terms to train both the noise model and the denoiser, where the first term is based on the first denoised signal and the second noisy signal, and the second term is based on the second denoised signal and the first noisy signal. By using noisy samples, the complexities of obtaining “clean” signals are avoided. By using “cross-sample” loss functions, convergence on undesired training results is avoided without complex regularization.

Abstract: A computer-implemented system and method for estimating a Cumulative Distribution Function (CDF) are provided. The method includes: receive input data representing a volume V of a target space indicating a future target event; compute, using the trained neural network, an estimation of a first flux through a boundary of the volume V; compute, using the trained neural network, an estimation of a second flux through a boundary of a volume W of a base space based on the estimation of the first flux through the boundary of the volume V; generate, using the trained neural network, an estimation of a CDF for the volume V based on the second flux through the boundary of the volume W; compute a probability for the future target event based on the estimated CDF for the volume V; and generate a control command based on the probability for the future target event.

Abstract: A system for machine learning architecture for time series data prediction. The system may be configured to: maintain a data set representing a neural network having a plurality of weights; obtain time series data associated with a data query; generate, using the neural network and based on the time series data, a predicted value based on a sampled realization of the time series data and a normalizing flow model, the normalizing flow model based on a latent continuous-time stochastic process having a stationary marginal distribution and bounded variance; and generate a signal providing an indication of the predicted value associated with the data query.

Abstract: The methods and systems are directed to computational approaches for training and using machine learning algorithms to predict the conditional marginal distributions of the position of agents at flexible evaluation horizons and can enables more efficient path planning. These methods model agent movement by training a deep neural network to predict the position of an agent through time. A neural ordinary differential equation (neural ODE) that represents this neural network can be used to determine the log-likelihood of the agent's position as it moves in time.

Abstract: Disclosed herein are systems and methods for efficient 3D structure estimation from images of a transmissive object, including cryo-EM images. The method generally comprises, receiving a set of 2D images of a target specimen from an electron microscope, carrying out a reconstruction technique to determine a likely molecular structure, and outputting the estimated 3D structure of the specimen. The described reconstruction technique comprises: establishing a probabilistic model of the target structure; optimizing using stochastic optimization to determine which structure is most likely; and, optionally utilizing importance sampling to minimize computational burden.

Abstract: Systems and methods for machine learning architecture for time series data prediction. The system may include a processor and a memory storing processor-executable instructions. The processor-executable instructions, when executed, may configure the processor to: obtain time series data associated with a data query; generate a predicted value based on a sampled realization of the time series data and a continuous time generative model, the continuous time generative model trained to define an invertible mapping to maximize a log-likelihood of a set of predicted values for a time range associated with the time series data; and generate a signal providing an indication of the predicted value associated with the data query.

Abstract: Disclosed herein are systems and methods for efficient 3D structure estimation from images of a transmissive object, including cryo-EM images. The method generally comprises, receiving a set of 2D images of a target specimen from an electron microscope, carrying out a reconstruction technique to determine a likely molecular structure, and outputting the estimated 3D structure of the specimen. The described reconstruction technique comprises: establishing a probabilistic model of the target structure; optimizing using stochastic optimization to determine which structure is most likely; and, optionally utilizing importance sampling to minimize computational burden.

Abstract: Disclosed herein are systems and methods for efficient 3D structure estimation from images of a transmissive object, including cryo-EM images. The method generally comprises, receiving a set of 2D images of a target specimen from an electron microscope, carrying out a reconstruction technique to determine a likely molecular structure, and outputting the estimated 3D structure of the specimen. The described reconstruction technique comprises: establishing a probabilistic model of the target structure; optimizing using stochastic optimization to determine which structure is most likely; and, optionally utilizing importance sampling to minimize computational burden.

Abstract: A system and a method for image alignment between at least two images to a three-dimensional model. The method including: determining a lower bound and an upper bound of an acceptable likelihood of mismatch between the at least two images; evaluating the likelihood of mismatch between the at least two images over a set of poses (r), shifts (t), or both poses (r) and shifts (t); and discarding those evaluations resulting beyond the lower bound and upper bound.

Abstract: A system and a method for image alignment between at least two images to a three-dimensional model. The method including: determining a lower bound and an upper bound of an acceptable likelihood of mismatch between the at least two images; evaluating the likelihood of mismatch between the at least two images over a set of poses (r), shifts (t), or both poses (r) and shifts (t); and discarding those evaluations resulting beyond the lower bound and upper bound.

Abstract: A system and a method for image alignment between at least two images to a three-dimensional model. The method including: determining a lower bound and an upper bound of an acceptable likelihood of mismatch between the at least two images; evaluating the likelihood of mismatch between the at least two images over a set of poses (r), shifts (t), or both poses (r) and shifts (t); and discarding those evaluations resulting beyond the lower bound and upper bound.

Abstract: A system and a method for image alignment between at least two images to a three-dimensional model. The method including: determining a lower bound and an upper bound of an acceptable likelihood of mismatch between the at least two images; evaluating the likelihood of mismatch between the at least two images over a set of poses (r), shifts (t), or both poses (r) and shifts (t); and discarding those evaluations resulting beyond the lower bound and upper bound.

Abstract: Disclosed herein are systems and methods for efficient 3D structure estimation from images of a transmissive object, including cryo-EM images. The method generally comprises, receiving a set of 2D images of a target specimen from an electron microscope, carrying out a reconstruction technique to determine a likely molecular structure, and outputting the estimated 3D structure of the specimen. The described reconstruction technique comprises: establishing a probabilistic model of the target structure; optimizing using stochastic optimization to determine which structure is most likely; and, optionally utilizing importance sampling to minimize computational burden.