Abstract: A data-brokerage service that facilitates data sharing between Internet-of-Things (IoT) platforms via peer-to-peer connections is described. In various embodiments, the data-brokerage service receives, from an IoT platform acting as data consumer, a selection of data fields included in a plurality of data streams provided from a plurality of respective IoT platforms acting as data producers. Responsive to the selection, the data-brokerage service causes the plurality of data-producer platforms to stream at least the selected data fields of the plurality of data streams to the data-consumer platform, and causes the data-consumer platform to combine the streamed data fields received from the plurality of data-producer platforms into a single target data stream.

Abstract: System and methods for enforcing service level agreements (SLAs) between computing platforms engaged in (e.g., Internet-of-Things) data exchange via peer-to-peer (P2P) connections are described. In accordance with various embodiments, data traffic via the P2P connections is monitored, and if an SLA violation is detected, data streams are rerouted to cure the violation.

Abstract: System and methods for enforcing service level agreements (SLAs) between computing platforms engaged in (e.g., Internet-of-Things) data exchange via peer-to-peer (P2P) connections are described. In accordance with various embodiments, data traffic via the P2P connections is monitored, and if an SLA violation is detected, data streams are rerouted to cure the violation.

Abstract: System and methods for enforcing service level agreements (SLAs) between computing platforms engaged in (e.g., Internet-of-Things) data exchange via peer-to-peer (P2P) connections are described. In accordance with various embodiments, data traffic via the P2P connections is monitored, and if an SLA violation is detected, data streams are rerouted to cure the violation.

Abstract: A data-brokerage service that facilitates data sharing between Internet-of-Things (IoT) platforms via peer-to-peer connections is described. In various embodiments, the data-brokerage service receives, from an IoT platform acting as data consumer, a selection of data fields included in a plurality of data streams provided from a plurality of respective IoT platforms acting as data producers. Responsive to the selection, the data-brokerage service causes the plurality of data-producer platforms to stream at least the selected data fields of the plurality of data streams to the data-consumer platform, and causes the data-consumer platform to combine the streamed data fields received from the plurality of data-producer platforms into a single target data stream.

Abstract: A data-brokerage service that facilitates data sharing between Internet-of-Things (IoT) platforms via peer-to-peer connections is described. In various embodiments, the data-brokerage service receives, from an IoT platform acting as data consumer, a selection of data fields included in a plurality of data streams provided from a plurality of respective IoT platforms acting as data producers. Responsive to the selection, the data-brokerage service causes the plurality of data-producer platforms to stream at least the selected data fields of the plurality of data streams to the data-consumer platform, and causes the data-consumer platform to combine the streamed data fields received from the plurality of data-producer platforms into a single target data stream.

Abstract: The present invention relates to spiropyrazine compounds which are inhibitors of non-apoptotic regulated cell death, and to pharmaceutical compositions containing such compounds. Furthermore, the present invention relates to the use of such compounds and pharmaceutical compositions in therapy, in particular in the treatment of a condition, disorder or disease that is characterised by non-apoptotic regulated cell-death or where non-apoptotic regulated cell-death is likely to play or plays a substantial role.

Abstract: A data-brokerage service that facilitates data sharing between Internet-of-Things (IoT) platforms via peer-to-peer connections is described. In various embodiments, the data-brokerage service receives, from an IoT platform acting as data consumer, a selection of data fields included in a plurality of data streams provided from a plurality of respective IoT platforms acting as data producers. Responsive to the selection, the data-brokerage service causes the plurality of data-producer platforms to stream at least the selected data fields of the plurality of data streams to the data-consumer platform, and causes the data-consumer platform to combine the streamed data fields received from the plurality of data-producer platforms into a single target data stream.

Abstract: A data-brokerage service that facilitates data sharing between Internet-of-Things (IoT) platforms via peer-to-peer connections is described. In various embodiments, the data-brokerage service receives, from an IoT platform acting as data consumer, a selection of data fields included in a plurality of data streams provided from a plurality of respective IoT platforms acting as data producers. Responsive to the selection, the data-brokerage service causes the plurality of data-producer platforms to stream at least the selected data fields of the plurality of data streams to the data-consumer platform, and causes the data-consumer platform to combine the streamed data fields received from the plurality of data-producer platforms into a single target data stream.

Abstract: The present invention relates to compounds which are inhibitors of non-apoptotic regulated cell death, and to pharmaceutical compositions containing such compounds. Furthermore, the present invention relates to the use of such compounds and pharmaceutical compositions in therapy, in particular in the treatment of a condition, disorder or disease that is characterized by non-apoptotic regulated cell-death or where non-apoptotic regulated cell-death is likely to play or plays a substantial role.

Abstract: The present invention relates to spiropyrazine compounds which are inhibitors of non-apoptotic regulated cell death, and to pharmaceutical compositions containing such compounds. Furthermore, the present invention relates to the use of such compounds and pharmaceutical compositions in therapy, in particular in the treatment of a condition, disorder or disease that is characterised by non-apoptotic regulated cell-death or where non-apoptotic regulated cell-death is likely to play or plays a substantial role.

Abstract: System and methods for enforcing service level agreements (SLAs) between computing platforms engaged in (e.g., Internet-of-Things) data exchange via peer-to-peer (P2P) connections are described. In accordance with various embodiments, data traffic via the P2P connections is monitored, and if an SLA violation is detected, data streams are rerouted to cure the violation.

Abstract: A data-brokerage service that facilitates data sharing between Internet-of-Things (IoT) platforms via peer-to-peer connections is described. In various embodiments, the data-brokerage service receives, from an IoT platform acting as data consumer, a selection of data fields included in a plurality of data streams provided from a plurality of respective IoT platforms acting as data producers. Responsive to the selection, the data-brokerage service causes the plurality of data-producer platforms to stream at least the selected data fields of the plurality of data streams to the data-consumer platform, and causes the data-consumer platform to combine the streamed data fields received from the plurality of data-producer platforms into a single target data stream.

Abstract: The present invention relates to compounds which are inhibitors of non-apoptotic regulated cell death, and to pharmaceutical compositions containing such compounds. Furthermore, the present invention relates to the use of such compounds and pharmaceutical compositions in therapy, in particular in the treatment of a condition, disorder or disease that is characterised by non-apoptotic regulated cell-death or where non-apoptotic regulated cell-death is likely to play or plays a substantial role.

Abstract: The present invention relates to compounds which are inhibitors of non-apoptotic regulated cell death, and to pharmaceutical compositions containing such compounds. Furthermore, the present invention relates to the use of such compounds and pharmaceutical compositions in therapy, in particular in the treatment of a condition, disorder or disease that is characterised by non-apoptotic regulated cell-death or where non-apoptotic regulated cell-death is likely to play or plays a substantial role.

Abstract: The present invention relates to compounds which are inhibitors of non-apoptotic regulated cell death, and to pharmaceutical compositions containing such compounds. Furthermore, the present invention relates to the use of such compounds and pharmaceutical compositions in therapy, in particular in the treatment of a condition, disorder or disease that is characterised by non-apoptotic regulated cell-death or where non-apoptotic regulated cell-death is likely to play or plays a substantial role.

Abstract: This invention relates to a novel form of the PHGPx protein, the sperm nuclei glutathione peroxidase (snGPx) as well as portions thereof playing a role in mammalian spermatogenesis, and to the nucleic acids encoding the same. The invention further relates to vectors containing said nucleic acid and to host cells transformed by these vectors. Furthermore the invention comprises antibodies specific for the above proteins/peptides as well as the use of the proteins/peptides in the diagnosis or therapy of male infertility.

Abstract: The present invention relates to compounds which are inhibitors of non-apoptotic regulated cell death, and to pharmaceutical compositions containing such compounds. Furthermore, the present invention relates to the use of such compounds and pharmaceutical compositions in therapy, in particular in the treatment of a condition, disorder or disease that is characterised by non-apoptotic regulated cell-death or where non-apoptotic regulated cell-death is likely to play or plays a substantial role.