Patents by Inventor Marcus F. Brackeen

Marcus F. Brackeen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intermediates for making analgesic N-phenyl-N-(3-OR.sup.1 -3-Me-4-piperidinyl)amides
    Patent number: 5387688
    Abstract: Novel piperidinyl intermediates as set forth below wherein R, R.sup.1 and Ar are as set forth in the specification and W is either hydrogen or benzyloxycarbonyl. The intermediates are useful in the preparation of N-phenyl-N-(4-piperidinyl) amides having potent analgesic activity.
    Type: Grant
    Filed: December 11, 1992
    Date of Patent: February 7, 1995
    Assignee: Glaxo Inc.
    Inventors: Paul L. Feldman, Marcus F. Brackeen
  • Analgesic N-phenyl-N-(3-OR.sub.1 -3-ME-4-piperidinyl)amides
    Patent number: 5214148
    Abstract: N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I): ##STR1## wherein X, Ar, R and R.sup.1 are defined, including isomeric forms thereof and acid addition salts thereof. The compounds exhibit analgesic activity. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).
    Type: Grant
    Filed: July 2, 1992
    Date of Patent: May 25, 1993
    Assignee: Glaxo Inc.
    Inventors: Paul L. Feldman, Marcus F. Brackeen
  • Analgesic n-phenyl-n-(3-or 1-3-me-4-piperidinyl)amides
    Patent number: 5130321
    Abstract: N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I): ##STR1## wherein X, Ar, R and R.sup.1 are defined, including isomeric forms thereof and acid addition salts thereof. The compounds exhibit analgesic activity. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).
    Type: Grant
    Filed: December 18, 1990
    Date of Patent: July 14, 1992
    Assignee: Glaxo Inc.
    Inventors: Paul L. Feldman, Marcus F. Brackeen
  • Preparation of substituted alkali metal piperidine-4-carboxylates
    Patent number: 5126455
    Abstract: A method of preparing certain substituted alkali metal 4-carboxy-piperidine salts (I) by alkaline hydrolysis of certain novel substituted 1,3,8-triazaspiro[4.5]decane-2, 4-diones (IV) which in turn are obtained from certain novel substituted chlorosulphonylamido piperidines (III).
    Type: Grant
    Filed: June 10, 1991
    Date of Patent: June 30, 1992
    Assignee: GLAXO Inc.
    Inventors: Paul L. Feldman, Marcus F. Brackeen
  • Preparation of substituted alkali metal piperidine-4-carboxylates
    Patent number: 5039804
    Abstract: A method of preparing certain substituted alkali metal 4-carboxy-piperidine salts (I) by alkaline hydrolysis of certain novel substituted 1,3,8-triazaspiro[4.5]decane-2, 4-diones (IV) which in turn are obtained from certain novel substituted chlorosulphonylamido piperidines (III).
    Type: Grant
    Filed: December 13, 1989
    Date of Patent: August 13, 1991
    Assignee: Glaxo Inc.
    Inventors: Paul L. Feldman, Marcus F. Brackeen
  • N-phenyl-N-(4-piperidinyl)amides useful as analgesics
    Patent number: 5019583
    Abstract: N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I): ##STR1## wherein X is a member selected from the group consisting of alkoxy-carbonyl-lower alkyl, lower alkyl-carbonyloxy-lower alkyl, alkenyloxy-carbonyl-lower alkyl, and (C.sub.1-2)alkoxy-(C.sub.1-2)-alkoxy-carbonyl-lower alkyl, and Ar, R, R.sup.1 and R.sup.2 are defined hereinafter, including isomeric forms thereof and acid addition salts thereof. The compounds exhibit analgesic activity having relatively short durations of analgesic action. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).
    Type: Grant
    Filed: December 11, 1989
    Date of Patent: May 28, 1991
    Assignee: Glaxo Inc.
    Inventors: Paul L. Feldman, Michael K. James, Marcus F. Brackeen, Michael R. Johnson, Harry J. Leighton