Abstract: The present invention relates to the field of machines for cleaning, particularly vacuum cleaning devices. There is disclosed a filter cartridge for a vacuum cleaner comprising first and second opposite end walls, a side wall or walls which extend between the end walls so as to define an enclosure which surrounds a filter interior, wherein one or more of the walls comprises filter membrane material, the cartridge having an opening provided through the first end wall for receiving air-entrained detritus into the interior, the opening being defined by a rigid support structure which spans and supports the first end wall of the cartridge. The cartridge typically includes a non-return valve which closes when suction is removed so as to help prevent collected detritus escaping from the filter cartridge interior. The valve may comprise a conical valve with flexible facets, or a cantilever flap.

Abstract: Hydrophobic drugs become more practical for treatments by being encapsulated in micelle compositions for increasing solubility. Micelle compositions may include an excipient tocopherol and/or prodrug formulations of the drug. Micelles extend the time period the drug remains in the micelles to improve drug circulation time and thereby drug delivery. Hydrophobic drugs for micelle encapsulation may include rapamycin, geldanamycin, and paclitaxel. Administration of these micelle compositions does not require Cremophor EL or Tween 80, avoiding serious side effects associated with these products which would previously accompany such drug administration.