Abstract: Disclosed are devices and methods directed to oxygenators for use in extracorporeal circuits for supporting a fetus. An oxygenator for use with an extracorporeal circuit includes a housing defining a cavity therein and a gas exchanger disposed within the interior cavity. The cavity is configured to receive blood a fetus. The gas exchanger is configured to receive a sweep gas and further configured to contact the blood within the cavity, such that at least oxygen gas and carbon dioxide gas is permitted to diffuse between the blood and the gas exchanger.

Abstract: Physiological saline solutions (PSS) and methods for making and using same are disclosed relating to extracorporeal fetal care. In one aspect, disclosed herein is a PSS comprising: an aqueous solvent; from about 1.0 mM to about 2.0 mM calcium chloride; from about 3.0 mM to about 5.0 mM potassium chloride; from about 15.0 mM to about 20 mM sodium bicarbonate; from about 90 mM to about 110 mM sodium chloride; and from about 9 to about 13 mM sodium acetate; and optionally at least one buffering agent wherein the solution has a pH ranging from about 7.0 to about 7.4. In this or other aspects the solution has an osmolarity ranging from about 250 to about 270 mOsm.

Abstract: Extracorporeal membrane oxygenation systems and methods of use are disclosed. Several publications and patent documents are cited throughout the specification in order to describe the state of the art to which this invention pertains. Full citations of these references can be found throughout the specification. Each of these citations is incorporated herein by reference as though set forth in full.

Abstract: A cannula insertion system for cannulating a blood vessel includes a cannula system having a cannula that defines a cannula lumen and has a distal and proximal end. The system includes a cannula insertion device for coupling with the system that includes a dilator having a dilator body and a dilator lumen; a needle having a needle body and a needle lumen, the needle being translatable within the dilator lumen along a first direction; a movable dilator actuator configured to cause the dilator to move along the first direction; a movable needle actuator configured to cause movement of the needle along the first direction; and a housing defining a housing recess. The housing recess is configured to receive the cannula system, the dilator, and the needle. The needle and the dilator are configured to be moved within the cannula lumen along the first direction.

Abstract: Extracorporeal membrane oxygenation systems and methods of use are disclosed. Several publications and patent documents are cited throughout the specification in order to describe the state of the art to which this invention pertains. Full citations of these references can be found throughout the specification. Each of these citations is incorporated herein by reference as though set forth in full.