Abstract: A fan control system for a computer system is provided. The computer system includes a fan and a target device. The fan control system includes a controller to control the rotation speed of the fan. The controller determines a time-variable rate of the rotation speed according to an operating parameter of the target device. Particularly, the controller determines the time-variable rate of the rotation speed according to a ratio of the consumed power to the rated power of the target device. Alternatively, the controller can determine the rotation speed according to the ratio of the consumed power to the rated power of the target device.

Abstract: The present invention provides antibodies that bind to the class III variant of EGFR (EGFRvIII) and methods of using the same. According to certain embodiments, the antibodies of the invention bind human EGFRvIII with high affinity. The antibodies of the invention may be fully human antibodies. The invention includes anti-EGFRvIII antibodies conjugated to a cytotoxic agent, radionuclide, or other moiety detrimental to cell growth or proliferation. The antibodies of the invention are useful for the treatment of various cancers.

Abstract: Radiolabeled anti-LAG3 antibodies and their use in immuno-PET imaging are provided herein. Included are methods of detecting the presence of LAG3 proteins in a patient or sample.

Abstract: The present invention provides antibodies that bind to the class III variant of EGFR (EGFRvIII) and methods of using the same. According to certain embodiments, the antibodies of the invention bind human EGFRvIII with high affinity. The antibodies of the invention may be fully human antibodies. The invention includes anti-EGFRvIII antibodies conjugated to a cytotoxic agent, radionuclide, or other moiety detrimental to cell growth or proliferation. The antibodies of the invention are useful for the treatment of various cancers.

Abstract: Provided herein are methods of treating prolactin receptor positive breast cancer using an antibody drug conjugate (ADC) comprising an anti-PRLR antibody or antigen-binding fragment thereof conjugated to a cytotoxic agent. In certain embodiments, the anti-PRLR antibody or antigen-binding fragment thereof is conjugated to maytansinoid. In certain embodiments, the method of treating PRLR positive breast cancer includes administering the ADC in combination with one or more chemotherapeutic agents.

Abstract: Radiolabeled anti-PD-L1 antibodies and their use in immuno-PET imaging are provided herein. Included are methods of detecting the presence of PD-L1 proteins in a patient or sample.

Abstract: Mucin 16 (MUC16) is highly expressed in ovarian cancer and expression on cancer cells is shown to protect tumor cells from the immune system. The present invention provides novel full-length human IgG antibodies that bind to human and MUC16 (monospecific antibodies). The present invention also provides novel bispecific antibodies (bsAbs) that bind to both MUC16 and CD3 and activate T cells via the CD3 complex in the presence of MUC16-expressing tumors. According to certain embodiments, the present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human and monkey CD3, and a second antigen-binding molecule that specifically binds human and monkey MUC16. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of tumors expressing MUC16.

Abstract: Mucin 16 (MUC16) is highly expressed in ovarian cancer and expression on cancer cells is shown to protect tumor cells from the immune system. The present invention provides novel full-length human IgG antibodies that bind to human and MUC16 (monospecific antibodies). The present invention also provides novel bispecific antibodies (bsAbs) that bind to both MUC16 and CD3 and activate T cells via the CD3 complex in the presence of MUC16-expressing tumors. According to certain embodiments, the present invention provides bispecific antigen-binding molecules comprising a first antigen-binding domain that specifically binds human and monkey CD3, and a second antigen-binding molecule that specifically binds human and monkey MUC16. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of tumors expressing MUC16.

Abstract: The present invention provides antibodies that bind to the class III variant of EGFR (EGFRvIII) and methods of using the same. According to certain embodiments, the antibodies of the invention bind human EGFRvIII with high affinity. The antibodies of the invention may be fully human antibodies. The invention includes anti-EGFRvIII antibodies conjugated to a cytotoxic agent, radionuclide, or other moiety detrimental to cell growth or proliferation. The antibodies of the invention are useful for the treatment of various cancers.

Abstract: The present invention provides antibodies that bind to the class III variant of EGFR (EGFRvIII) and methods of using the same. According to certain embodiments, the antibodies of the invention bind human EGFRvIII with high affinity. The antibodies of the invention may be fully human antibodies. The invention includes anti-EGFRvIII antibodies conjugated to a cytotoxic agent, radionuclide, or other moiety detrimental to cell growth or proliferation. The antibodies of the invention are useful for the treatment of various cancers.

Abstract: A method for controlling a fan is described and includes controlling a rotation speed of a fan according to a first rotation speed time-variable rate by a controller, and controlling the rotation speed of the fan according to a second rotation speed time-variable rate by the controller in response to a change in an operating parameter of a target device, where the fan and target device are for use in a computer system.

Abstract: Disclosed is a method for identifying a fan type of a fan in an electronic system having a controller. The method includes: setting a fan identification characteristic value, the fan identification characteristic value corresponding to a PWM (pulse width modulation) duty cycle with a substantial maximum difference between the fan speed of a first type of fan and the fan speed a second type of fan; receiving, via the fan, the fan identification characteristic value; initiating the fan with the fan identification characteristic value; reading, via the controller, a stable fan speed value of the fan; identifying, via the controller, the fan type of the fan based on which fan has a predetermined fan speed (RPM) that is the closest to the stable fan speed value (RPM) when operating at the fan identification characteristic value (PWM).

Abstract: A fan identification system identifies a fan type of a fan in an electronic system. The fan identification system includes a controller that includes: a setting module for setting a fan identification characteristic value corresponding to a pulse width modulation duty cycle with a substantial maximum difference between a fan speed of a first type of fan and a fan speed of a second type of fan; a reading module for reading a stable fan speed value after the fan receives the fan identification characteristic value and is initiated with the fan identification characteristic value; and an identification module for identifying the fan as the first type of fan or the second type of fan based on which fan has a predetermined fan speed that is the closest to the stable fan speed value when operating at the fan identification characteristic value.

Abstract: The present invention provides antibodies that bind to the class III variant of EGFR (EGFRvIII) and methods of using the same. According to certain embodiments, the antibodies of the invention bind human EGFRvIII with high affinity. The antibodies of the invention may be fully human antibodies. The invention includes anti-EGFRvIII antibodies conjugated to a cytotoxic agent, radionuclide, or other moiety detrimental to cell growth or proliferation. The antibodies of the invention are useful for the treatment of various cancers.

Abstract: A fan control system for a computer system is provided. The computer system includes a fan and a target device. The fan control system includes a controller to control the rotation speed of the fan. The controller determines a time-variable rate of the rotation speed according to an operating parameter of the target device. Particularly, the controller determines the time-variable rate of the rotation speed according to a ratio of the consumed power to the rated power of the target device. Alternatively, the controller can determine the rotation speed according to the ratio of the consumed power to the rated power of the target device.

Abstract: Disclosed is a method for identifying a fan type of a fan in an electronic system having a controller. The method includes: setting a fan identification characteristic value, the fan identification characteristic value corresponding to a PWM (pulse width modulation) duty cycle with a substantial maximum difference between the fan speed of a first type of fan and the fan speed a second type of fan; receiving, via the fan, the fan identification characteristic value; initiating the fan with the fan identification characteristic value; reading, via the controller, a stable fan speed value of the fan; identifying, via the controller, the fan type of the fan based on which fan has a predetermined fan speed (RPM) that is the closest to the stable fan speed value (RPM) when operating at the fan identification characteristic value (PWM).

Abstract: A fan identification system identifies a fan type of a fan in an electronic system. The fan identification system includes a controller that includes: a setting module for setting a fan identification characteristic value corresponding to a pulse width modulation duty cycle with a substantial maximum difference between a fan speed of a first type of fan and a fan speed of a second type of fan; a reading module for reading a stable fan speed value after the fan receives the fan identification characteristic value and is initiated with the fan identification characteristic value; and an identification module for identifying the fan as the first type of fan or the second type of fan based on which fan has a predetermined fan speed that is the closest to the stable fan speed value when operating at the fan identification characteristic value.

Abstract: A system and method of controlling the system mode of a computer. The method comprises sending an Intelligent Platform Management Interface (IPMI) command to a baseboard management controller (BMC), wherein the IPMI command provides a system mode instruction to the BMC. The BMC then sends an operating parameter instruction to a plurality of hardware devices within the computer in response to receiving the IPMI command, wherein the operating parameter instruction sent to the plurality of hardware devices is associated with the system mode. Accordingly, each of the hardware devices operates according to the operating parameter instruction received from the BMC. Preferably, such a method allows the system mode to be changed without shutting down an operating system or rebooting the computer system. Optionally, the BMC may communicate with the hardware devices over an Inter Integrated Circuit (I2C) bus, a General Purpose Input Output (GPIO) pin of the BMC, or a combination thereof.