Patents by Inventor Marcus Lambertus

Marcus Lambertus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210228682
    Abstract: The invention relates to the fields of biochemistry, pharmacy and oncology. The invention particularly relates to the use of novel stem cell markers for the isolation of stem cells. The invention further relates to the obtained stem cells and their use in for example research or treatment, for example, for the preparation of a medicament for the treatment of damaged or diseased tissue. In one of the embodiments, the invention provides a method for obtaining (or isolating) stem cells comprising optionally preparing a cell suspension from a tissue or organ sample, contacting said cell suspension with an Lgr 6 or 5 binding compound, identify the cells bound to said binding compound, and optionally isolating the stem cells from said binding compound. The invention further relates to means suitable for cancer treatment and even more specific for the treatment of cancer by eradicating cancer stem cells.
    Type: Application
    Filed: January 28, 2021
    Publication date: July 29, 2021
    Applicant: Koninklijke Nederlandse Akademie van Wetenschappen
    Inventors: Johannes Carolus Clevers, Nicholas Barker, Andrea Haegebarth, Marcus Lambertus Van de Wetering
  • Patent number: 10940180
    Abstract: The invention relates to the fields of biochemistry, pharmacy and oncology. The invention particularly relates to the use of novel stem cell markers for the isolation of stem cells. The invention further relates to the obtained stem cells and their use in for example research or treatment, for example, for the preparation of a medicament for the treatment of damaged or diseased tissue. In one of the embodiments, the invention provides a method for obtaining (or isolating) stem cells comprising optionally preparing a cell suspension from a tissue or organ sample, contacting said cell suspension with an Lgr 6 or 5 binding compound, identify the cells bound to said binding compound, and optionally isolating the stem cells from said binding compound. The invention further relates to means suitable for cancer treatment and even more specific for the treatment of cancer by eradicating cancer stem cells.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: March 9, 2021
    Assignee: Koninklijke Nederlandse Akademie van Wetenschappen
    Inventors: Johannes C. Clevers, Nicholas Barker, Andrea Haegebarth, Marcus Lambertus Van de Wetering
  • Publication number: 20180221441
    Abstract: The invention relates to the fields of biochemistry, pharmacy and oncology. The invention particularly relates to the use of novel stem cell markers for the isolation of stem cells. The invention further relates to the obtained stem cells and their use in for example research or treatment, for example, for the preparation of a medicament for the treatment of damaged or diseased tissue. In one of the embodiments, the invention provides a method for obtaining (or isolating) stem cells comprising optionally preparing a cell suspension from a tissue or organ sample, contacting said cell suspension with an Lgr 6 or 5 binding compound, identify the cells bound to said binding compound, and optionally isolating the stem cells from said binding compound. The invention further relates to means suitable for cancer treatment and even more specific for the treatment of cancer by eradicating cancer stem cells.
    Type: Application
    Filed: November 15, 2017
    Publication date: August 9, 2018
    Applicant: Koninklijke Nederlandse Akademie van Wetenschappen
    Inventors: Johannes C. Clevers, Nicholas Barker, Andrea Haegebarth, Marcus Lambertus Van de Wetering
  • Patent number: 9833496
    Abstract: The invention relates to the fields of biochemistry, pharmacy and oncology. The invention particularly relates to the use of novel stem cell markers for the isolation of stem cells. The invention further relates to the obtained stem cells and their use in for example research or treatment, for example, for the preparation of a medicament for the treatment of damaged or diseased tissue. In one of the embodiments, the invention provides a method for obtaining (or isolating) stem cells comprising optionally preparing a cell suspension from a tissue or organ sample, contacting said cell suspension with an Lgr 6 or 5 binding compound, identify the cells bound to said binding compound, and optionally isolating the stem cells from said binding compound. The invention further relates to means suitable for cancer treatment and even more specific for the treatment of cancer by eradicating cancer stem cells.
    Type: Grant
    Filed: September 23, 2014
    Date of Patent: December 5, 2017
    Assignee: Koninklijke Nederlandse Akademie van Wetenschappen
    Inventors: Johannes C. Clevers, Nicholas Barker, Andrea Haegebarth, Marcus Lambertus Van de Wetering
  • Publication number: 20170151308
    Abstract: The invention relates to the fields of biochemistry, pharmacy and oncology. The invention particularly relates to the use of novel stem cell markers for the isolation of stem cells. The invention further relates to the obtained stem cells and their use in for example research or treatment, for example, for the preparation of a medicament for the treatment of damaged or diseased tissue. In one of the embodiments, the invention provides a method for obtaining (or isolating) stem cells comprising optionally preparing a cell suspension from a tissue or organ sample, contacting said cell suspension with an Lgr 6 or 5 binding compound, identify the cells bound to said binding compound, and optionally isolating the stem cells from said binding compound. The invention further relates to means suitable for cancer treatment and even more specific for the treatment of cancer by eradicating cancer stem cells.
    Type: Application
    Filed: September 23, 2014
    Publication date: June 1, 2017
    Applicant: Koninklijke Nederlandse Akademie van Wetenschappen
    Inventors: Johannes C. Clevers, Nicholas Barker, Andrea Haegebarth, Marcus Lambertus Van de Wetering
  • Publication number: 20150231201
    Abstract: The invention relates to the fields of biochemistry, pharmacy and oncology. The invention particularly relates to the use of novel stem cell markers for the isolation of stem cells. The invention further relates to the obtained stem cells and their use in for example research or treatment, for example, for the preparation of a medicament for the treatment of damaged or diseased tissue. In one of the embodiments, the invention provides a method for obtaining (or isolating) stem cells comprising optionally preparing a cell suspension from a tissue or organ sample, contacting said cell suspension with an Lgr 6 or 5 binding compound, identify the cells bound to said binding compound, and optionally isolating the stem cells from said binding compound. The invention further relates to means suitable for cancer treatment and even more specific for the treatment of cancer by eradicating cancer stem cells.
    Type: Application
    Filed: September 23, 2014
    Publication date: August 20, 2015
    Applicant: Koninklijke Nederlandse Akademie van Wetenschappen
    Inventors: Johannes C. Clevers, Nicholas Barker, Andrea Haegebarth, Marcus Lambertus Van de Wetering
  • Patent number: 8906631
    Abstract: Described are the use of stem cell markers for the isolation of stem cells and the use of the obtained stem cells in, for example, research or treatment, such as for the preparation of a medicament for the treatment of damaged or diseased tissue. In one aspect, provided is a method for obtaining or isolating stem cells that comprises preparing a cell suspension from a tissue or organ sample, contacting the cell suspension with an Lgr 6 or 5 binding compound, identifying the cells bound to the binding compound, and isolating the stem cells from the binding compound. Further described are methods and compositions for cancer treatment, for example, by eradicating cancer stem cells.
    Type: Grant
    Filed: May 10, 2010
    Date of Patent: December 9, 2014
    Assignee: Koninklijke Nederlandse Akademie van Wetenschappen
    Inventors: Johannes Carolus Clevers, Nicholas Barker, Andrea Haegebarth, Marcus Lambertus Van de Wetering
  • Patent number: 7288184
    Abstract: Disclosed is a process for removing acids in a system in which aromatic hydrocarbons are separated from a mixture with aliphatic hydrocarbons. The aromatic hydrocarbons are extracted from the mixture using an extracting solvent. The aromatic hydrocarbons are stripped from the extracting solvent with steam and the steam is condensed to form water which is separated from the aromatic hydrocarbons. The separated water is passed through a basic anion exchange column and is then heated to produce the steam.
    Type: Grant
    Filed: December 10, 2004
    Date of Patent: October 30, 2007
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Marcus Lambertus Hendricus van Nuland, John Joseph Monson
  • Publication number: 20060165699
    Abstract: The present invention relates to the use of inhibitors of the expressed proteins of TCF target genes whose expression is regulated by TCF/?-catenin complexes for the preparation of a therapeutical composition for the treatment of cancers in which TCF/?-catenin signalling is deregulated. Such inhibitors can be antibodies, small molecules, antisense RNA and dsRNA for use in RNAi. The invention also relates to these inhibitors per se.
    Type: Application
    Filed: July 8, 2003
    Publication date: July 27, 2006
    Inventors: Frederic Colland, Nicholas Barker, Johannes Clevers, Eduard Gomez, Marcus Lambertus, Elena Suils
  • Publication number: 20060124509
    Abstract: Disclosed is a process for removing acids in a system in which aromatic hydrocarbons are separated from a mixture with aliphatic hydrocarbons. The aromatic hydrocarbons are extracted from the mixture using an extracting solvent. The aromatic hydrocarbons are stripped from the extracting solvent with steam and the steam is condensed to form water which is separated from the aromatic hydrocarbons. The separated water is passed through a basic anion exchange column and is then heated to produce the steam.
    Type: Application
    Filed: December 10, 2004
    Publication date: June 15, 2006
    Inventors: Marcus Lambertus Van Nuland, John Monson
  • Publication number: 20040058392
    Abstract: The invention relates to the use of the expression products of the TCF target genes as markers for the isolation of intestinal stem cells in a method for the isolation of intestinal stem cells by providing antibodies, antibody derivatives or ligand fusion proteins against one or more of the target gene products of the genes; providing single cell suspensions of intestinal tissue; contacting the antibodies, antibody derivatives or ligand fusion proteins and the single cell suspensions; identifying the cells binding to the antibodies, antibody derivatives or ligand fusion proteins; and optionally isolating the stem cells from the antibodies, antibody derivatives or ligand fusion proteins.
    Type: Application
    Filed: September 17, 2002
    Publication date: March 25, 2004
    Applicant: Kylix B.V.
    Inventors: Johannes Carolus Clevers, Eduard Batlle Gomez, Marcus Lambertus Van De Wetering, Elena Sancho Suils
  • Publication number: 20040005313
    Abstract: The present invention relates to the use of inhibitors of the expressed proteins of TCF target genes whose expression is regulated by TCF/&bgr;-catenin complexes for the preparation of a therapeutical composition for the treatment of cancers in which TCF/&bgr;-catenin signaling is deregulated. Such inhibitors can be antibodies, small molecules, antisense RNA and dsRNA for use in RNAi. The invention also relates to these inhibitors per se.
    Type: Application
    Filed: July 16, 2002
    Publication date: January 8, 2004
    Applicant: Kylix B.V.
    Inventors: Johannes Carolus Clevers, Eduard Batle Gomez, Marcus Lambertus Van De Wetering, Elena Sancho Suils