Abstract: The invention features a method of producing aggregates of a plurality of cell populations (e.g., a first population of cells and a second population of cells). The method includes agitating a liquid medium that contains the cells in a bioreactor. These aggregates may be used for subsequent downstream applications, such as encapsulation in a biocompatible scaffold to form an engineered tissue construct.

Abstract: The instant disclosure provides a system comprising a plurality of stacked bioreactors, wherein the system is configured to provide a substantially equal flow rate of fluid and pressure drop through each of the plurality of bioreactors. In some embodiments, the flow of the fluid through each of the plurality of bioreactors is configured to generate physiological shear rates to induce a biological source material in the bioreactors to produce target biological products.

Abstract: There is provided a method of making a fluidic system that comprises assembling a fluidic system comprising a first plate, a second plate and a membrane disposed between the first plate and the second plate; applying laser energy to the fluidic system to cause the first plate, the second plate and the membrane to melt at bonding areas; and allowing the bonding areas to cool down such that the first plate, the second plate and the membrane are bonded together.

Abstract: A submergible wave energy converter and method for using the same are described. In one embodiment, the wave energy converter may be used for deep water operations. In one embodiment, the submergible wave energy converter is an autonomous unmanned vehicle that enables remote ocean power generation. In one embodiment, the wave energy converter apparatus comprises an absorber having a body with an upper surface and a bottom surface and at least one power take-off (PTO) unit coupled to the absorber and configured to displace movement of the absorber body relative to a reference, where the power take-off unit is operable to perform motion energy conversion based on displacement of the absorber body relative to the reference in response to wave excitation, and where the power take-off unit is operable to return the absorber body from a displaced position to a predefined equilibrium position and to provide a force acting on the absorber body for energy extraction.

Abstract: Disclosed herein are non-naturally existing novel platelet variants or platelet like cells (PLCs), extracellular vesicles (EVs), and derivatives thereof. Composition comprising the same and methods for treatment or prevention of diseases or disorders therewith is also disclosed.

Abstract: A submergible wave energy converter and method for using the same are described. Such a wave energy converter may be used for deep water operations. In one embodiment, the wave energy converter apparatus comprises an absorber having a body with an upper surface and a bottom surface and at least one power take-off (PTO) unit coupled to the absorber and configured to displace movement of the absorber body relative to a reference, where the power take-off unit is operable to perform motion energy conversion based on displacement of the absorber body relative to the reference in response to wave excitation, and where the power take-off unit is operable to return the absorber body from a displaced position to a predefined equilibrium position and to provide a force acting on the absorber body for energy extraction.

Abstract: Disclosed herein are non-naturally existing novel platelet variants or platelet like cells (PLCs), extracellular vesicles (EVs), and derivatives thereof. Composition comprising the same and methods for treatment or prevention of diseases or disorders therewith is also disclosed.

Abstract: A submergible wave energy converter and method for using the same are described. In one embodiment, the wave energy converter may be used for deep water operations. In one embodiment, the submergible wave energy converter is an autonomous unmanned vehicle that enables remote ocean power generation. In one embodiment, the wave energy converter apparatus comprises an absorber having a body with an upper surface and a bottom surface and at least one power take-off (PTO) unit coupled to the absorber and configured to displace movement of the absorber body relative to a reference, where the power take-off unit is operable to perform motion energy conversion based on displacement of the absorber body relative to the reference in response to wave excitation, and where the power take-off unit is operable to return the absorber body from a displaced position to a predefined equilibrium position and to provide a force acting on the absorber body for energy extraction.

Abstract: The instant disclosure provides a system comprising a plurality of stacked bioreactors, wherein the system is configured to provide a substantially equal flow rate of fluid and pressure drop through each of the plurality of bioreactors. In some embodiments, the flow of the fluid through each of the plurality of bioreactors is configured to generate physiological shear rates to induce a biological source material in the bioreactors to produce target biological products.

Abstract: A submergible wave energy converter and method for using the same are described. Such a wave energy converter may be used for deep water operations. In one embodiment, the wave energy converter apparatus comprises an absorber having a body with an upper surface and a bottom surface and at least one power take-off (PTO) unit coupled to the absorber and configured to displace movement of the absorber body relative to a reference, where the power take-off unit is operable to perform motion energy conversion based on displacement of the absorber body relative to the reference in response to wave excitation, and where the power take-off unit is operable to return the absorber body from a displaced position to a predefined equilibrium position and to provide a force acting on the absorber body for energy extraction.

Abstract: A submerged wave energy conversion apparatus and pressurized fluid or electricity production system are provided that harvests energy from a motive force derived from pressure differentials created by the interaction of the system with ocean water. The system is capable of capturing energy from up to six different modes of motion of the absorber body in response to the energy of incident waves. The apparatus has an absorber body that is attached to one or more damping mechanisms like a hydraulic cylinder, a hydraulic circuit that can create useful mechanical torque, a restoring mechanism such as an air spring to restore the absorber system to stable equilibrium, and a buoyant artificial floor to create an opposing reaction force. The apparatus may also have a controller for system monitoring and control, to maintain optimized energy extraction, and for load management to avoid damaging loads.

Abstract: A submerged wave energy conversion apparatus and pressurized fluid or electricity production system are provided that harvests energy from a motive force derived from pressure differentials created by the interaction of the system with ocean water. The system is capable of capturing energy from up to six different modes of motion of the absorber body in response to the energy of incident waves. The apparatus has an absorber body that is attached to one or more damping mechanisms like a hydraulic cylinder, a hydraulic circuit that can create useful mechanical torque, a restoring mechanism such as an air spring to restore the absorber system to stable equilibrium, and a buoyant artificial floor to create an opposing reaction force. The apparatus may also have a controller for system monitoring and control, to maintain optimized energy extraction, and for load management to avoid damaging loads.

Abstract: A submergible wave energy converter and method for using the same are described. Such a wave energy converter may be used for deep water operations. In one embodiment, the wave energy converter apparatus comprises an absorber having a body with an upper surface and a bottom surface and at least one power take-off (PTO) unit coupled to the absorber and configured to displace movement of the absorber body relative to a reference, where the power take-off unit is operable to perform motion energy conversion based on displacement of the absorber body relative to the reference in response to wave excitation, and where the power take-off unit is operable to return the absorber body from a displaced position to a predefined equilibrium position and to provide a force acting on the absorber body for energy extraction.

Abstract: A carpet of wave energy conversion (CWEC) device mechanically couples an absorber carpet to one or more energy converters, thereby allowing for wave energy extraction from passing waves. The absorber carpet may be flexible material of a composite material that has a low elastic modulus in a longitudinal direction (to allow for stretching), and a relatively higher elastic modulus in a transverse direction (to better couple energy from wave to converters). Such designs have minimal wave reflections and high efficiencies within a relatively short extent of deployment. The resultant converted useful energy is available as either: 1) mechanical power including direct desalinization or electrical production; or 2) hydraulic power for a number of applications (including hydraulically powered motors supplying power to powered devices including generators), or pumping of the wave medium under pressure to an alternate location for irrigation or energy storage.

Abstract: A carpet of wave energy conversion (CWEC) device mechanically couples an absorber carpet to one or more energy converters, thereby allowing for wave energy extraction from passing waves. The absorber carpet may be flexible material of a composite material that has a low elastic modulus in a longitudinal direction (to allow for stretching), and a relatively higher elastic modulus in a transverse direction (to better couple energy from wave to converters). Such designs have minimal wave reflections and high efficiencies within a relatively short extent of deployment. The resultant converted useful energy is available as either: 1) mechanical power including direct desalinization or electrical production; or 2) hydraulic power for a number of applications (including hydraulically powered motors supplying power to powered devices including generators), or pumping of the wave medium under pressure to an alternate location for irrigation or energy storage.

Abstract: A method to determine at least one triggering parameter of personal protection device of a vehicle using pattern signal curves of a possible signal of a sensor for a physical variable. The pattern signal curves replicating a curve over time of the physical variable upon impact of an object on the vehicle at a different location on the vehicle and/or upon impact of the object on the vehicle at a different angle. A sensor signal is read which represents the physical variable measured by a sensor. Values of a curve over time of the sensor signal are compared to values of the at least two pattern signal curves, that pattern signal curve being selected which, in at least one time segment of the pattern signal curve or one scaled form of the pattern signal curve has a lower deviation from the curve over time of the sensor signal.