Patents by Inventor Marcus Malek

Marcus Malek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Radionuclide and near-infrared dye conjugated antibody for detection of GD2-positive cancer
    Patent number: 12766202
    Abstract: Disclosed herein is an antibody-conjugate comprising a monoclonal antibody that specifically binds to GD2 and comprises a heavy chain and a light chain comprising heavy and light chain variable regions set forth as SEQ ID NOs: 3 and 4, respectively. The monoclonal antibody can be conjugated to a near-infrared fluorescent dye and diethylenetriaminepentaacetic acid (DTPA). In several aspects, the antibody-conjugate further comprising Indium-111 (111In) chelated by the DTPA. The antibody-conjugate specifically binds to GD2, and is useful, for example, in radio-guided and fluorescent-guided surgical techniques for intraoperative detection of GD2-positive cancer tissue.
    Type: Grant
    Filed: November 3, 2023
    Date of Patent: October 20, 2026
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, The Curators of the University of Missouri
    Inventors: Marcus Malek, Gary Kohanbash, Wilson Barry Edwards, Lauren Rosenblum
  • RADIONUCLIDE AND NEAR-INFRARED DYE CONJUGATED ANTIBODY FOR DETECTION OF GD2-POSITIVE CANCER
    Publication number: 20260166186
    Abstract: Disclosed herein is an antibody-conjugate comprising a monoclonal antibody that specifically binds to GD2 and comprises a heavy chain and a light chain comprising heavy and light chain variable regions set forth as SEQ ID NOs: 3 and 4, respectively. The monoclonal antibody can be conjugated to a near-infrared fluorescent dye and diethylenetriaminepentaacetic acid (DTPA). In several aspects, the antibody-conjugate further comprising Indium-111 (111In) chelated by the DTPA. The antibody-conjugate specifically binds to GD2, and is useful, for example, in radio-guided and fluorescent-guided surgical techniques for intraoperative detection of GD2-positive cancer tissue.
    Type: Application
    Filed: November 3, 2023
    Publication date: June 18, 2026
    Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, The Curators of the University of Missouri
    Inventors: Marcus Malek, Gary Kohanbash, Wilson Barry Edwards, Lauren Rosenblum