Abstract: Methods of using an apparatus for generating dielectrophoretic electromagnetic fields (dc-DEP EMF) to enhance cell polarity through the application of dc-DEP EMF force to stabilize Hyaluronan Mediated Motility Receptor (HMMR) and differentially modulate its expression in cancerous and noncancerous cells. A significant down regulation of HMMR when coupled with the decreased cell growth/mitosis and decreased mitotic spindle formation in treated human breast carcinoma cells indicating a decreased cell motility/migration/metastasis occurs when the cancerous cells are exposed to the dc-DEP EMF force. An improved apparatus for generating dielectrophoretic electromagnetic fields comprising crystals in the center of the orb for enhanced bio-field, a power supply toroidal flow of direct current to the orb, sensing capabilities to measure impedance, and customization of electromagnetic signals emitted by the apparatus and the power supply.

Abstract: The method of enhancing diamagnetic anisotropy in cell membranes that occur under the influence of disassociated polymorphic bCl? comprising changes in chloride ion channel expression and cell physiology. Direct current from a device generates an electromagnetic field in a 3 hypotonic saline solution leading to a dielectrophoretic disassociation of the chloride ion from its chloro-metabolites transforming it into a polymorphic diamagnetically disassociated bio-chloride (bCl?). This field treated aqueous solution induces a magnetic moment change in solution for some hours when no longer under the influence of the direct current; for when this field influenced solution is used to reconstitute growth media of human breast carcinoma (MDA-MB-231) and human breast epithelial (MCF-10A) cells in vitro, significant changes in chloride ion channel expression, membrane potential, cell volume, and a massive transcriptional reprogramming of 2,468 genes expressions by Human Genome U133 Plus 2.

Abstract: Disclosed are methods and devices utilizing bioelectrodynamics for the therapeutic treatment of disorders in a subject in need thereof with an electric field or electromagnetic field therapy. The methods and devices provide an inhibitory effect on growth of cancer cells that are exposed to an electromagnetic field generated by a CETS unit. Cancer cells may arrest proliferation and enter apoptosis by activation of the unfolded protein response (UPR), TNF/TRAIL, and p53 oncogene activation. The methods and devices may be used to enhance wound healing with exposure to an electromagnetic field generated by a CETS unit. Noncancerous cells may show a significant increase in cell migration with no activation of apoptosis pathways.