Patents by Inventor Marcy Zenobi-Wong
Marcy Zenobi-Wong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230398262Abstract: The present invention relates to the medical use of a zwitterionic antifouling hydrogel. The hydrogel may be used in prevention of and protection against inflammation of tissue or in stabilization of a tissue implant.Type: ApplicationFiled: June 8, 2023Publication date: December 14, 2023Applicant: ETH ZURICHInventors: Maryam Asadikorayem, Marcy Zenobi-Wong, Patrick Christian Weber, Frantisek Surman
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Publication number: 20230321320Abstract: The present invention relates to a method of providing a graft scaffold for cartilage repair, particularly in a human patient. The method of the invention comprising the steps of providing particles and/or fibres; providing an aqueous solution of a gelling polysaccharide; providing mammalian cells; mixing said particles and/or fibres, said aqueous solution of a gelling polysaccharide and said mammalian cells to obtain a printing mix; and depositing said printing mix in a three-dimensional form. The invention further relates to graft scaffolds and grafts obtained by the method of the invention.Type: ApplicationFiled: March 30, 2023Publication date: October 12, 2023Applicant: ETH ZurichInventors: Matti KESTI, Marcy ZENOBI-WONG, Michael MULLER
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Patent number: 11633518Abstract: The present invention relates to a method of providing a graft scaffold for cartilage repair, particularly in a human patient. The method of the invention comprising the steps of providing particles and/or fibres; providing an aqueous solution of a gelling polysaccharide; providing mammalian cells; mixing said particles and/or fibres, said aqueous solution of a gelling polysaccharide and said mammalian cells to obtain a printing mix; and depositing said printing mix in a three-dimensional form. The invention further relates to graft scaffolds and grafts obtained by the method of the invention.Type: GrantFiled: January 7, 2020Date of Patent: April 25, 2023Assignee: ETH ZURICHInventors: Matti Kesti, Marcy Zenobi-Wong, Michael Muller
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Patent number: 10980887Abstract: The present invention relates to a method for providing an embedded mammalian cell, comprising the steps of providing an alginate sulfate in aqueous solution; reacting the alginate sulfate to form a hydrogel in a gelation step, providing a precursor cell, and embedding the precursor cell in the sulfated alginate hydrogel in an embedding step, thus yielding an sulfated alginate hydrogel embedded cell. The invention further relates to sulfated alginate hydrogels, and cellular grafts comprising a mammalian cell embedded in sulfated alginate hydrogel.Type: GrantFiled: February 23, 2018Date of Patent: April 20, 2021Assignee: ETH ZURICHInventors: Marcy Zenobi-Wong, Gemma Palazzolo, Rami Mhanna, Jana Becher, Stefanie Moller, Matthias Schnabelrauch
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Publication number: 20200139007Abstract: The present invention relates to a method of providing a graft scaffold for cartilage repair, particularly in a human patient. The method of the invention comprising the steps of providing particles and/or fibres; providing an aqueous solution of a gelling polysaccharide; providing mammalian cells; mixing said particles and/or fibres, said aqueous solution of a gelling polysaccharide and said mammalian cells to obtain a printing mix; and depositing said printing mix in a three-dimensional form. The invention further relates to graft scaffolds and grafts obtained by the method of the invention.Type: ApplicationFiled: January 7, 2020Publication date: May 7, 2020Applicant: ETH ZurichInventors: Matti KESTI, Marcy ZENOBI-WONG, Michael MULLER
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Patent number: 10532126Abstract: The present invention relates to a method of providing a graft scaffold for cartilage repair, particularly in a human patient. The method of the invention comprising the steps of providing particles and/or fibres; providing an aqueous solution of a gelling polysaccharide; providing mammalian cells; mixing said particles and/or fibres, said aqueous solution of a gelling polysaccharide and said mammalian cells to obtain a printing mix; and depositing said printing mix in a three-dimensional form. The invention further relates to graft scaffolds and grafts obtained by the method of the invention.Type: GrantFiled: December 11, 2015Date of Patent: January 14, 2020Assignee: ETH ZURICHInventors: Matti Kesti, Marcy Zenobi-Wong, Michael Muller
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Publication number: 20190160202Abstract: The invention relates to a process for forming a hyaluronan hydrogel, comprising the steps of a. providing a hyaluronan donor peptide conjugate and a hyaluronan acceptor peptide conjugate each represented by a general formula I, wherein 10% of R1 moieties are represented by a general formula II, wherein L is a 2 to 6 atom linker moiety and Pep is a transglutaminase donor or acceptor peptide, and the rest of R1 moieties are represented by —COOH. b. adding a factor XIII polypeptide and a thrombin polypeptide, or a factor XIIIa polypeptide. The invention further relates to compositions and hydrogels characterized by the depicted chemistry.Type: ApplicationFiled: May 4, 2017Publication date: May 30, 2019Applicant: ETH ZÜRICHInventors: Nicolas BROGUIERE, Emma CAVALLI, Marcy ZENOBI-WONG
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Publication number: 20190010288Abstract: The present technology provides nanocomposite compositions that include about 0.1 wt. % to about 40 wt. % of nanoparticles having a net cationic charge by weight of the composition; about 0.1 wt. % to about 50 wt. % of one or more gelling agents by weight of the composition; and a solvent that includes a protic solvent. Methods of preparing a three-dimensional structure via the nanocomposite composition are also disclosed.Type: ApplicationFiled: June 5, 2018Publication date: January 10, 2019Applicant: ETH ZÜRICHInventors: Mihyun LEE, Marcy ZENOBI-WONG, Jin CHANG
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Publication number: 20180264176Abstract: The inventions relates to a method for generating a macroporous hydrogel. In a first step, an aqueous solution of two solutes is produced. The first solute is a polymer that can be cross-linked and is a derivative of polyethylene glycol (PEG) or polyoxazoline (POx) and the second solute is a kosmotropic agent. In a second step, a cross-linking agent is added to the solution. This simultaneously initiates gelation of the polymer and phase-separation, thus creating a macroporous hydrogel. The invention further relates to a macroporous hydrogel, which can be obtained by the inventive method. This macroporous hydrogel is comprised of a cross-linked polymer, which is a derivative of polyethylene glycol (PEG) or polyoxazoline (POx). The hydrogel exhibits interconnected macropores with a size of 200 nm to 1000 ?m, particularly 500 nm to 100 ?m and is characterized by a pH of of 7.0 to 8.0, particularly approx. 7.4.Type: ApplicationFiled: September 8, 2016Publication date: September 20, 2018Applicant: ETH ZurichInventors: Nicolas BROGUIERE, Marcy ZENOBI-WONG
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Publication number: 20180177882Abstract: The present invention relates to a method for providing an embedded mammalian cell, comprising the steps of providing an alginate sulfate in aqueous solution; reacting the alginate sulfate to form a hydrogel in a gelation step, providing a precursor cell, and embedding the precursor cell in the sulfated alginate hydrogel in an embedding step, thus yielding an sulfated alginate hydrogel embedded cell. The invention further relates to sulfated alginate hydrogels, and cellular grafts comprising a mammalian cell embedded in sulfated alginate hydrogel.Type: ApplicationFiled: February 23, 2018Publication date: June 28, 2018Applicant: ETH ZurichInventors: Marcy ZENOBI-WONG, Gemma PALAZZOLO, Rami MHANNA, Anne BECHER, Stefanie MOLLER, Matthias SCHNABELRAUCH
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Patent number: 9937257Abstract: The present invention relates to a method for providing an embedded mammalian cell, comprising the steps of providing an alginate sulfate in aqueous solution; reacting the alginate sulfate to form a hydrogel in a gelation step, providing a precursor cell, and embedding the precursor cell in the sulfated alginate hydrogel in an embedding step, thus yielding an sulfated alginate hydrogel embedded cell. The invention further relates to sulfated alginate hydrogels, and cellular grafts comprising a mammalian cell embedded in sulfated alginate hydrogel.Type: GrantFiled: November 4, 2013Date of Patent: April 10, 2018Assignee: ETH ZurichInventors: Marcy Zenobi-Wong, Gemma Palazzolo, Rami Mhanna, Jana Becher, Stefanie Moller, Matthias Schnabelrauch
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Publication number: 20170348458Abstract: The present invention relates to a method of providing a graft scaffold for cartilage repair, particularly in a human patient. The method of the invention comprising the steps of providing particles and/or fibres; providing an aqueous solution of a gelling polysaccharide; providing mammalian cells; mixing said particles and/or fibres, said aqueous solution of a gelling polysaccharide and said mammalian cells to obtain a printing mix; and depositing said printing mix in a three-dimensional form. The invention further relates to graft scaffolds and grafts obtained by the method of the invention.Type: ApplicationFiled: December 11, 2015Publication date: December 7, 2017Applicant: ETH ZurichInventors: Matti KESTI, Marcy ZENOBI-WONG, Michael MULLER
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Publication number: 20160377601Abstract: A method of making a three-dimensional microtissue comprising the reaction of at least two cytocompatible polymer solutions, each polymer comprising complementary reactive groups capable of spontaneous reaction, at least one of which solutions additionally contains cells. The method allows the rapid, efficient production of microtissues useful for purposes such as pharmaceutical screening and tissue reconstruction.Type: ApplicationFiled: July 2, 2014Publication date: December 29, 2016Inventors: Marcy ZENOBI-WONG, Yuan Yang, Thomas GROTH, Christopher MILLAN, David MIRANDA-NIEVES
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Publication number: 20150290327Abstract: The present invention relates to a method for providing an embedded mammalian cell, comprising the steps of providing an alginate sulfate in aqueous solution; reacting the alginate sulfate to form a hydrogel in a gelation step, providing a precursor cell, and embedding the precursor cell in the sulfated alginate hydrogel in an embedding step, thus yielding an sulfated alginate hydrogel embedded cell. The invention further relates to sulfated alginate hydrogels, and cellular grafts comprising a mammalian cell embedded in sulfated alginate hydrogel.Type: ApplicationFiled: November 4, 2013Publication date: October 15, 2015Applicant: ETH ZURICHInventors: Marcy Zenobi-Wong, Gemma Palazzolo, Rami Mhanna, Jana Becher, Stefanie Moller, Matthias Schnabelrauch, Ece Oeztuerk, Oystein Arlov
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Publication number: 20130244895Abstract: The present invention relates to a bioanalytical device consisting of a microwell array with microwell (2) that are filled with assay components (12, 15, 36), wherein detection probes (36) used in the assay (10) are metal nanoparticles (11, 12) or fluorescent compounds, and wherein the microwell array is connected and/or connectable to a sample that is on a flat substrate (6) to quantify the amount of a ligand (35) in the sample by using a detection mechanism. The detection mechanism is based on change in the optical properties of some of the assay components (12, 15, 36) upon contact with the ligand (35). The present invention also relates further to a method for detecting and quantifying molecules using said bioanalytical device.Type: ApplicationFiled: August 18, 2011Publication date: September 19, 2013Applicant: ETH ZURICH, ETH TRANSFERInventors: Janos Vörös, Marcy Zenobi-Wong, Prayanka Rajendra
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Publication number: 20120087980Abstract: Flavonoid glycosides, such as isoquercitrin, are shown to stimulate the formation of neuritis and neuronal synapses in neurons and neuronal progenitor (stem) cells.Type: ApplicationFiled: September 30, 2011Publication date: April 12, 2012Inventor: Marcy Zenobi-Wong