Patents by Inventor Marek Honczarenko

Marek Honczarenko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10435475
    Abstract: A method of treating an inflammatory bowel disease is provided. The method comprises administration of an antibody polypeptide that specifically binds a novel epitope of human CD40. The antibody polypeptides do not exhibit CD40 agonist activity. The antibody polypeptides may be fusions of a domain antibody (dAb) comprising a single VL or VH domain and an Fc domain.
    Type: Grant
    Filed: March 9, 2015
    Date of Patent: October 8, 2019
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Marek Honczarenko, Vaishali Shah, Xiaoni Liu, Wendy L. Trigona, Rong Shi, Suzanne J. Suchard, Karen D. Price, Linda M. Gustavson
  • Publication number: 20170306034
    Abstract: Methods of treating autoimmune diseases, such as primary immune thrombocytopenia (ITP), solid organ transplant rejection, graft-related disease, pemphigus vulgaris, systemic sclerosis, and myasthenia gravis using antibody polypeptides that specifically bind human CD40L are provided. The antibody polypeptides do not activate platelets. The methods may comprise at least one administration cycle comprising one dose of the antibody polypeptide. The dose may be administered intravenously at a dose from about 75 mg to about 1500 mg. The method normalizes platelet counts in the human patient.
    Type: Application
    Filed: September 10, 2015
    Publication date: October 26, 2017
    Inventors: Marek HONCZARENKO, Vaishali SHAH, Lixin LANG, Urvi ARAS, Diane SHEVELL, Christine KRATT, Karen PRICE, Suzanne SUCHARD
  • Publication number: 20170240636
    Abstract: Methods of treating autoimmune diseases, such as systemic lupus erythematosus using domain antibodies that specifically bind human CD28 are provided. The methods may comprise at least one administration cycle comprising one dose of the domain antibody. The method reduces symptoms of systemic lupus erythematosus compared to placebo.
    Type: Application
    Filed: September 30, 2015
    Publication date: August 24, 2017
    Inventors: Xavier Valencia, John P. Throup, Steven G. Nadler, Suzamme J. Suchard, Dominique Duchesne, Xiaoni Liu, Rong Shi, Diane E. Shevell, Jenny H. Xie, Marek Honczarenko
  • Publication number: 20160355596
    Abstract: A method of treating an inflammatory bowel disease is provided. The method comprises administration of an antibody polypeptide that specifically binds a novel epitope of human CD40. The antibody polypeptides do not exhibit CD40 agonist activity. The antibody polypeptides may be fusions of a domain antibody (dAb) comprising a single VL or VH domain and an Fc domain.
    Type: Application
    Filed: March 9, 2015
    Publication date: December 8, 2016
    Inventors: Marek HONCZARENKO, Shah VAISHALI, Xiaoni LIU, Wendy L. TRIGONA, Rong SHI, Suzanne J. SUCHARD, Karen D. PRICE, Linda M. GUSTAVSON
  • Publication number: 20140286959
    Abstract: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The invention also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies.
    Type: Application
    Filed: November 2, 2012
    Publication date: September 25, 2014
    Applicant: PFIZER Inc.
    Inventors: Martin Hegen, Deborah Young, Heath Guay, Kyriaki Dunussi-Joannopoulos, Sudhakar Sridharan, Annette Diehl, Gail Comer, Margot O'Toole, Jean Beebe, Robert Fogel, Marek Honczarenko, David Beidler, Padmalatha S. Reddy, David J. von Schack