Patents by Inventor Marek Kovar

Marek Kovar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for Improving Immune Function and Methods for Prevention or Treatment of Disease in a Mammalian Subject
    Publication number: 20130142755
    Abstract: A method for increasing a biological activity of a cytokine or lymphokine and a method of treating a neoplastic disease, autoimmune disease, or infectious disease, and a method for expanding a hematopoietic cell population, is provided by administering an antibody capable of binding a cytokine or by administering a cytokine complexed with an antibody or by administering a cytokine complexed with a cytokine receptor to a mammalian subject in need thereof.
    Type: Application
    Filed: June 26, 2012
    Publication date: June 6, 2013
    Inventors: Onur Boyman, Charles D. Surh, Jonathan Sprent, Mark Rubinstein, Marek Kovar
  • PH-sensitive polymeric conjugates of an anthracycline cancerostatic drug for targeted therapy
    Patent number: 7919076
    Abstract: Conjugates consisting of a polymeric carrier constituted by 30 to 3,000 monomer units linked to form a polymeric chain, composed of a) 60 to 99% of N-(2-hydroxypropyl)methacrylamide units, b) 1 to 25% of units of methacryloylated hydrazones of ?-amino acids, ?-amino acids, aromatic amino acids or oligopeptides terminated with a molecule of an anthracycline cancerostatic, c) 0.5 to 15% of units of methacryloylated ?-amino acids, ?-amino acids, aromatic amino acids or oligopeptides or their sodium salts.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: April 5, 2011
    Assignee: Zentiva, k.s.
    Inventors: Karel Ulbrich, Tomas Etrych, Blanka Rihova, Marketa Jelinkova, Marek Kovar
  • Methods for Improving Immune Function and Methods for Prevention or Treatment of Disease in a Mammalian Subject
    Publication number: 20100310501
    Abstract: A method for increasing a biological activity of a cytokine or lymphokine and a method of treating a neoplastic disease, autoimmune disease, or infectious disease, and a method for expanding a hematopoietic cell population, is provided by administering an antibody capable of binding a cytokine or by administering a cytokine complexed with an antibody or by administering a cytokine complexed with a cytokine receptor to a mammalian subject in need thereof.
    Type: Application
    Filed: February 16, 2007
    Publication date: December 9, 2010
    Inventors: Onur Boyman, Charles D. Surh, Jonathan Sprent, Mark Rubinstein, Marek Kovar
  • Ph-sensitive polymeric conjugates of an anthracycline cancerostatic drug for targeted therapy
    Publication number: 20060057099
    Abstract: Conjugates consisting of a polymeric carrier constituted by 30 to 3,000 monomer units linked to form a polymeric chain, composed of a) 60 to 99% of N-(2-hydroxypropyl)methacrylamide units, b) 1 to 25% of units of methacryloylated hydrazones of ?-amino acids, ?-amino acids, aromatic amino acids or oligopeptides terminated with a molecule of an anthracycline cancerostatic, c) 0.5 to 15% of units of methacryloylated ?-amino acids, ?-amino acids, aromatic amino acids or oligopeptides or their sodium salts.
    Type: Application
    Filed: December 20, 2002
    Publication date: March 16, 2006
    Inventors: Karel Ulbrich, Tornas Etrych, Blanka Rihova, Marketa Jekinkoya, Marek Kovar