Patents by Inventor Marek Kubiszewski

Marek Kubiszewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process of vitamin Kderivatives preparation
    Patent number: 11407704
    Abstract: Provided is an improved process of vitamin K2 derivatives preparation, represented by formula (I) wherein n is an integer from 3 to 13.
    Type: Grant
    Filed: April 6, 2019
    Date of Patent: August 9, 2022
    Assignee: Siec Badawcza Lukasiewicz-Instytut Chemii Przemyslowej imienia Profesora Ignacego Moscickiego
    Inventors: Katarzyna Sidoryk, Marek Napiorkowski, Agnieszka Burzynska-Prajzner, Marcin Cybulski, Marek Kubiszewski, Kamil Jatczak, Lukasz Jedynak, Jerzy Winiarski, Dorota Pietrzkowska, Konrad Zielinski
  • ACID ADDITION SALT OF PYRIMETHAMINE
    Publication number: 20220235012
    Abstract: Acid addition salt of pyrimethamine (5-4-chlorophenyl)-6-ethyl-2,4-pyrimidinediamine) and methane sulfonic acid, process for its preparation and pharmaceutical compositions comprising the acid addition salt are disclosed.
    Type: Application
    Filed: March 22, 2019
    Publication date: July 28, 2022
    Inventors: LUKAWSZ KACZMAREK, MARTA LASZCZ, GRZEGORZ HUSZCZA, MALGORZATA SKAZNIK, MARTA ZEZULA, ALEKSANDRA GROMAN, ELZBIETA STOLARCZYK, MAREK KUBISZEWSKI, KINGA TRZCINSKA, KRZYSZTOF KUZIAK
  • PROCESS OF VITAMIN K2 DERIVATIVES PREPARATION
    Publication number: 20210317060
    Abstract: Provided is an improved process of vitamin K2 derivatives preparation, represented by formula (I) wherein n is an integer from 3 to 13.
    Type: Application
    Filed: April 6, 2019
    Publication date: October 14, 2021
    Inventors: Katarzyna SIDORYK, Marek NAPIORKOWSKI, Agnieszka BURZYNSKA-PRAJZNER, Marcin CYBULSKI, Marek KUBISZEWSKI, Kamil JATCZAK, Lukasz JEDYNAK, Jerzy WINIARSKI, Dorota PIETRZKOWSKA, Konrad ZIELINSKI
  • Process for preparation of MK-7 type of vitamin K2
    Patent number: 9828323
    Abstract: Process for preparation of MK-7 type of vitamin K2 is characterized by attaching hexaprenyl chain of “all-trans” configuration to monoprenyl derivative of menadiol following “1+6” synthetic strategy. According to the invention, a-sulfonyl carbanion generated in situ from the protected monoprenyl menadiol of the formula (II), wherein R1 represents C1-3-alkyl group, is reacted with hexaprenyl halide of the formula (VII), wherein X represents halogen atom, preferably bromine, both Z? and Z? represent H or one of Z? and Z? represents H and the other represents phenylsulfonyl group —SO2Ph in the alkylation reaction. The hexaprenyl halide of formula (VII) is obtained by coupling two triprenyl units in alkylation reaction, with or without separation of the intermediates.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: November 28, 2017
    Assignee: Nattopharma R & D Ltd.
    Inventors: Krzysztof Krajewski, Andrzej Kutner, Jadwiga Dzikowska, Regina Gutowska, Marek Napiórkowski, Jerzy Winiarski, Marek Kubiszewski, Łukasz Jedynak, Jacek Morzycki, Stanislaw Witkowski, Aneta Baj, Piotr Wałejko
  • PROCESS FOR PREPARATION OF MK-7 TYPE OF VITAMIN K2
    Publication number: 20150291498
    Abstract: Process for preparation of MK-7 type of vitamin K2 is characterized by attaching hexaprenyl chain of “all-trans” configuration to monoprenyl derivative of menadiol following “1+6” synthetic strategy. According to the invention, a-sulfonyl carbanion generated in situ from the protected monoprenyl menadiol of the formula (II), wherein R1 represents C1-3-alkyl group, is reacted with hexaprenyl halide of the formula (VII), wherein X represents halogen atom, preferably bromine, both Z? and Z? represent H or one of Z? and Z? represents H and the other represents phenylsulfonyl group —SO2Ph in the alkylation reaction. The hexaprenyl halide of formula (VII) is obtained by coupling two triprenyl units in alkylation reaction, with or without separation of the intermediates.
    Type: Application
    Filed: October 11, 2013
    Publication date: October 15, 2015
    Applicant: NATTOPHARMA R&D LTD
    Inventors: Krzysztof KRAJEWSKI, Andrzej KUTNER, Jadwiga DZIKOWSKA, Regina GUTOWSKA, Marek NAPIÓRKOWSKI, Jerzy WINIARSKI, Marek KUBISZEWSKI, Lukasz JEDYNAK, Jacek MORZYCKI, Stanislaw WITKOWSKI, Aneta BAJ, Piotr WALEJKO
  • NEW SYNTHONES FOR PREPARATION OF 19-NOR VITAMIN D DERIVATIVES
    Publication number: 20130006003
    Abstract: The present invention discloses the synthone of Formula (I), wherein R1 and R2 are the same or different and represent independently hydrogen atom or hydroxyl protecting group, and its use for preparation of 19-nor vitamin D derivatives of general Formula (IV), wherein represents single or double bond, p represents an integer 0 to 3, R1 and R2 represent independently hydrogen atom or hydroxyl protecting group, R3 represents hydrogen atom, CH3 or hydroxyl group, R4, R5 and R6 represent independently hydrogen atom, C1-C3-alkyl or hydroxyl group or two of R4, R5 and R6 substituents altogether form cyclopropyl group, in particular for preparation of paricalcitol.
    Type: Application
    Filed: August 7, 2010
    Publication date: January 3, 2013
    Applicant: INSTYTUT FARMACEUTYCZNY
    Inventors: Michal Chodynski, Malgorzata Krupa, Krzysztof Krajewski, Marek Kubiszewski, Andrzej Kutner, Anita Pietraszek, Kinga Trzcinska