Patents by Inventor Marek Stanislaw KOMISARSKI

Marek Stanislaw KOMISARSKI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE DE-TRITYLATION OF OLIGONUCLEOTIDES
    Publication number: 20240092823
    Abstract: The invention relates to a novel process for the production of a linear P-linked oligonucleotide which comprises the removal of the acid labile 5?hydroxy protecting group at the 5?-O oligonucleotide with a detritylation solution comprising acetonitrile. The process allows to produce oligonucleotides with low content of depurination and N?1 impurities.
    Type: Application
    Filed: August 15, 2023
    Publication date: March 21, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Marek Stanislaw KOMISARSKI, Pascal MUELLER, Martin OLBRICH