Patents by Inventor Margaret A. Lindorfer

Margaret A. Lindorfer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhancing the efficacy of immunotherapies by supplementing with complement
    Patent number: 7255858
    Abstract: The present invention is directed to a composition and method for enhancing the complement-mediated cytotoxicity of therapeutic antibodies for their target cells (i.e. those cells displaying the target epitope). More particularly the present invention enhances the efficacy of such therapies by providing a supplemental source of complement.
    Type: Grant
    Filed: August 9, 2002
    Date of Patent: August 14, 2007
    Assignee: University of Virginia Patent Foundation
    Inventors: Ronald P. Taylor, Margaret A. Lindorfer, Michael D. Solga, Adam Kennedy
  • Therapeutic uses of complement receptor 2
    Publication number: 20040191252
    Abstract: The present invention is directed to an immune complex composition, and a method of using that complex to enhance an in viva immune response against a preselected target antigen. The immune complexes of the present invention comprise a monoclonal antibody specific for binding to complement receptor (CR2) site on B lymphocytes linked to a target antigen. As shown in FIG. SA-SD immune complexes bound to monkey B cells are removed in concert with loss of CR2. FIGS. SA and SB demonstrate the % AI488 HB135 and % APhCy CD21 positive cells, out of the doubly positive FE CD20/PerCF CD45 population over time, after injection of A1488 labeled HB135 (an anti-CR2 antibody, administration indicated by first arrow) followed by injection of rabbit anti-mouse IgG (administration indicated by the second arrow). FIGS. SC and SD are plots of the molecules of equivalent soluble fluorochome (MESF) values for these populations.
    Type: Application
    Filed: February 27, 2004
    Publication date: September 30, 2004
    Inventors: Ronald P. Taylor, Margaret A. Lindorfer, William M. Sutherland
  • Enhancing the efficacy of immunotherapies by supplementing with complement
    Publication number: 20040170633
    Abstract: The present invention is directed to a composition and method for enhancing the complement-mediated cytotoxicity of therapeutic antibodies for their target cells (i.e. those cells displaying the target epitope).
    Type: Application
    Filed: February 9, 2004
    Publication date: September 2, 2004
    Inventors: Ronald P Taylor, Margaret A. Lindorfer, Michael D. Solga, Adam A. Kennedy