Abstract: A disclosed server system for dynamically generating and serving content for presentation across different channels can perform the following operations: receive a request from a client device for a subset of content elements, the request designating a desired channel for presenting content in a page, identify the subset having at least one content attribute that satisfies one or more subset creation criteria indicating a category identifier for a slot in a page template used for generating the page, dynamically generate the subset by: for each content element in the subset, dynamically adjusting presentation of the singular instance of the content element based on presentation requirements of the desired channel, the singular instance being commonly used across all device interface types, and serve the subset of the content elements to the client device, which includes the singular instances of the content elements dynamically adjusted for presentation in the desired channel.

Abstract: The present disclosure is directed to a method of treating prediabetes or type 1 or type 2 diabetes mellitus comprising administering to a subject in need thereof an effective amount of imeglimin, wherein the subject has chronic kidney disease.

Abstract: The present disclosure relates to methods of diagnosing a dysbiosis in a subject, methods of determining a suitable treatment, and methods of treating a dysbiosis. In some aspects, the present disclosure relates to diagnosing or determining a subtype of irritable bowel syndrome (IBS).

Abstract: Compositions comprising 6,7-dihydroxybergamottin (6,7-DHB) and quercetin wherein the bioavailability of quercetin is enhanced as a result of the inhibition of cytochrome P450 enzymes from 6,7-DHB. The compositions are also used in methods of treating cancer, inflammation, cardiovascular disease, hypertension, polycystic ovary syndrome, a neurodegenerative disease, an infection or for enhancing cellular zinc uptake.

Abstract: Method and Systems for configuring, monitoring, updating and validating Internet of Things (IoT) software code and configuration using blockchain smart contract technology. The use of smart contracts for delivering software code and or configuration scripts to IoT devices is an enhanced cybersecurity solution meant to ensure the security and integrity of IoT devices. The use of smart contracts is also shown how it can be used for verifying the integrity of the IoT devices software code and or configuration is a proactive method of cybersecurity. The proactive cybersecurity method will prevent man in the middle attacks as well as preventing rogue devices from impacting other IoT devices or networks.

Abstract: The present disclosure is directed to a method of treating prediabetes or type 1 or type 2 diabetes mellitus comprising administering to a subject in need thereof an effective amount of imeglimin, wherein the subject has chronic kidney disease.

Abstract: The present disclosure relates to methods of diagnosing a dysbiosis in a subject, methods of determining a suitable treatment, and methods of treating a dysbiosis. In some aspects, the present disclosure relates to diagnosing or determining a subtype of irritable bowel syndrome (IBS).

Abstract: The present disclosure is directed to a method of treating prediabetes or type 1 or type 2 diabetes mellitus comprising administering to a subject in need thereof an effective amount of imeglimin, wherein the subject has chronic kidney disease.

Abstract: The present disclosure is directed to a method of treating prediabetes or type 1 or type 2 diabetes mellitus comprising administering to a subject in need thereof an effective amount of imeglimin, wherein the subject has chronic kidney disease.

Abstract: The present disclosure relates to methods of diagnosing a dysbiosis in a subject, methods of determining a suitable treatment, and methods of treating a dysbiosis. In some aspects, the present disclosure relates to diagnosing or determining a subtype of irritable bowel syndrome (IBS).

Abstract: Method and Systems for configuring, monitoring, updating and validating Internet of Things (IoT) software code and configuration using blockchain smart contract technology. The use of smart contracts for delivering software code and or configuration scripts to IoT devices is an enhanced cybersecurity solution meant to ensure the security and integrity of IoT devices. The use of smart contracts is also shown how it can be used for verifying the integrity of the IoT devices software code and or configuration is a proactive method of cybersecurity. The proactive cybersecurity method will prevent man in the middle attacks as well as preventing rogue devices from impacting other IoT devices or networks.

Abstract: This invention relates to the in vitro production of cyclic peptides using cyanobacterial enzymes, such as patellamide biosynthesis enzymes. Linear peptide substrates are cyclized using an isolated cyanbacterial macrocyclase, such as PatG from Prochloron spp. Before cyclization, residues in the linear peptide substrates may be heterocyclized using isolated cyanbacterial heterocyclasses, such as PatD or TruD heterocyclase. Methods of the invention may be useful, for example, for the production of cyclic peptidyl molecules, including cyclotides, such as katalas, and cyanobactins, such as patellamides and telomestatins, for example for use in the development of therapeutics.

Abstract: A method of displaying a home menu interface on a content viewing device, such as a television, is described. The interface is comprised of two components: a launcher and an accelerator. Each of these components include multiple tiles. One type of launcher tile represents a content source. The user can select this tile and enable a direct link to the content source application. Only after selecting the tile, does the content source application open. An accelerator is associated with a specific content source. An accelerator tile displays content previews or enables easy playback of content provided by the content source. The user can select an accelerator tile and enable a deep link to the content, taking the user straight to the content, bypassing a hierarchy of menu options.

Abstract: This invention relates to the in vitro production of cyclic peptides using cyanobacterial enzymes, such as patellamide biosynthesis enzymes. Linear peptide substrates are cyclized using an isolated cyanbacterial macrocyclase, such as PatG from Prochloron spp. Before cyclisation, residues in the linear peptide substrates may be heterocyclised using isolated cyanbacterial heterocyclasses, such as PatD or TruD heterocyclase. Methods of the invention may be useful, for example, for the production of cyclic peptidyl molecules, including cyclotides, such as katalas, and cyanobactins, such as patellamides and telomestatins, for example for use in the development of therapeutics.

Abstract: The invention generally relates to biodegradable and/or bioresorbable fibrous articles and more particularly to products and methods having utility in medical applications.

Abstract: A method of displaying a home menu interface on a content viewing device, such as a television, is described. The interface is comprised of two components: a launcher and an accelerator. Each of these components include multiple tiles. One type of launcher tile represents a content source. The user can select this tile and enable a direct link to the content source application. Only after selecting the tile, does the content source application open. An accelerator is associated with a specific content source. An accelerator tile displays content previews or enables easy playback of content provided by the content source. The user can select an accelerator tile and enable a deep link to the content, taking the user straight to the content, bypassing a hierarchy of menu options.

Abstract: A system for rendering data recorded on recordable media unreadable, the recordable media having a unique identifier, the system comprising:—means for reading said unique identifier from a recordable medium (104);—means for comparing said read unique identifier with a stored record of one or more unique identifiers of recordable media required to be processed (109);—means for generating an output indicative of whether or not said read unique identifiers matches one of said one or more unique identifiers in said stored record; and—means for rendering data recorded on a recordable medium unreadable only if said read unique identifier matches one of said one or more unique identifiers in said stored record (110).

Abstract: This invention relates to the in vitro production of cyclic peptides using cyanobacterial enzymes, such as patellamide biosynthesis enzymes. Linear peptide substrates are cyclized using an isolated cyanbacterial macrocyclase, such as PatG from Prochloron spp. Before cyclisation, residues in the linear peptide substrates may be heterocyclised using isolated cyanbacterial heterocyclases, such as PatD or TruD heterocyclase. Methods of the invention may be useful, for example, for the production of cyclic peptidyl molecules, including cyclotides, such as katalas, and cyanobactins, such as patellamides and telomestatins, for example for use in the development of therapeutics.

Abstract: The present invention is related to novel compounds of formula (I) having P2X7 antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans. (I).

Abstract: The invention generally relates to biodegradable and/or bioresorbable fibrous articles and more particularly to products and methods having utility in medical applications.