Patents by Inventor Margaret A. Thompson

Margaret A. Thompson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Proprotein convertase subtilisin kexin type 9 (PCSK9) allosteric binding ligands to modulate serum low density lipoprotein (LDL) levels
    Patent number: 10287317
    Abstract: This invention is related to the field of hypercholesterolemia. In particular, the invention provides compositions and methods to modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9 using synthetic ligands and/or synthetic ligand derivative sequences of 3-8 amino acids ranging between 350-2,000 Da. Altering the conformation of PCSK9 affects the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol. High LDL-cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunction; thus, there is also utility for ligands which can raise LDL levels.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: May 14, 2019
    Assignee: SRX Cardio, LLC
    Inventors: Michael M. Muehlemann, Thomas E. Barta, Kyle D. Monroe, Jonathan William Bourne, Margaret Thompson Reece, Vesa Nevalainen, Eric T. Baldwin
  • Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Allosteric Binding Ligands To Modulate Serum Low Density Lipoprotein (LDL) Levels
    Publication number: 20160083425
    Abstract: This invention is related to the field of hypercholesterolemia. In particular, the invention provides compositions and methods to modulate circulating levels of low density lipoproteins by altering the conformation of the protein PCSK9 using synthetic ligands and/or synthetic ligand derivative sequences of 3-8 amino acids ranging between 350-2,000 Da. Altering the conformation of PCSK9 affects the interaction between PCSK9 and an endogenous low density lipoprotein receptor, and can lead to reduced or increased levels of circulating LDL-cholesterol. High LDL-cholesterol levels are associated with increased risk for heart disease. Low LDL-cholesterol levels may be problematic in other conditions, such as liver dysfunction; thus, there is also utility for ligands which can raise LDL levels.
    Type: Application
    Filed: August 13, 2015
    Publication date: March 24, 2016
    Inventors: Michael M. Muehlemann, Thomas E. Barta, Kyle D. Monroe, Jonathan William Bourne, Margaret Thompson Reece, Vesa Nevalainen, Eric T. Baldwin
  • Pet boarding method and system
    Publication number: 20050246210
    Abstract: A system and method for matching pet owners with hosts for boarding pets is provided. Databases comprising host information and pet owner information are provided and matching of pet owners and hosts based upon predetermined criteria stored in the databases.
    Type: Application
    Filed: April 14, 2005
    Publication date: November 3, 2005
    Applicant: SLEEPOVER ROVER
    Inventor: Margaret Thompson
  • Topical amino acid - vitamin complex compositions for pharmaceutical and cosmetic use
    Patent number: 5425954
    Abstract: The invention provides a composition for topical application to the skin comprising a mixture of Panthenol (B.sub.5), Cod Liver Oil, Alpha Tocopherol Acetate, Arginine, Isoleucine, Leucine, Methionine, Phenylalanine, Threonine, and Valine in admixture with a suitable carrier. These compositions are particularly useful for the treatment of burns, cuts, abrasions, insect bites, inflammation from sun and wind exposure, dry skin, psoriasis, seborrheic dermatitis, and eczema.
    Type: Grant
    Filed: September 30, 1993
    Date of Patent: June 20, 1995
    Assignee: Curafas Incorporated
    Inventors: Margaret A. Thompson, Allan R. Cameron, John W. Manning