Patents by Inventor Margaret Alison Wheatley

Margaret Alison Wheatley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SURFACTANT MICROBUBBLES AND PROCESS FOR PREPARING AND METHODS OF USING THE SAME
    Publication number: 20220218825
    Abstract: The invention relates to an ultrasound contrast agent (UCA) comprising an outer shell and a gas core. The gas core is filled with oxygen, and the outer shell comprises a first surfactant and a second surfactant. The invention also relates to a method of making an oxygen-filled UCA and delivering oxygen to a local area of a subject's body. The method comprises injecting a composition comprising an oxygen-filled UCA of the invention into the subject's body; directing ultrasound radiation to the local area in an intensity sufficient to rupture the UCA.
    Type: Application
    Filed: March 29, 2022
    Publication date: July 14, 2022
    Applicants: Drexel University, Thomas Jefferson University
    Inventors: John Robert Eisenbrey, Margaret Alison Wheatley, Patrick O'Kane, Lorenzo Albala, Flemming Forsberg
  • Surfactant microbubbles and process for preparing and methods of using the same
    Patent number: 11305013
    Abstract: The invention relates to an ultrasound contrast agent (UCA) comprising an outer shell and a gas core. The gas core is filled with oxygen, and the outer shell comprises a first surfactant and a second surfactant. The invention also relates to a method of making an oxygen-filled UCA and delivering oxygen to a local area of a subject's body. The method comprises injecting a composition comprising an oxygen-filled UCA of the invention into the subject's body; directing ultrasound radiation to the local area in an intensity sufficient to rupture the UCA.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: April 19, 2022
    Assignees: Drexel University, Thomas Jefferson University
    Inventors: John Robert Eisenbrey, Margaret Alison Wheatley, Patrick O'Kane, Lorenzo Albala, Flemming Forsberg
  • SURFACTANT MICROBUBBLES AND PROCESS FOR PREPARING AND METHODS OF USING THE SAME
    Publication number: 20160059036
    Abstract: The invention relates to an ultrasound contrast agent (UCA) comprising an outer shell and a gas core. The gas core is filled with oxygen, and the outer shell comprises a first surfactant and a second surfactant. The invention also relates to a method of making an oxygen-filled UCA and delivering oxygen to a local area of a subject's body. The method comprises injecting a composition comprising an oxygen-filled UCA of the invention into the subject's body; directing ultrasound radiation to the local area in an intensity sufficient to rupture the UCA.
    Type: Application
    Filed: August 25, 2015
    Publication date: March 3, 2016
    Inventors: John Robert Eisenbrey, Margaret Alison Wheatley, Patrick O'Kane, Lorenzo Albala, Flemming Forsberg
  • IMPROVED CARRIERS FOR DELIVERY OF NUCLEIC ACID AGENTS TO CELLS AND TISSUES
    Publication number: 20090011004
    Abstract: This invention relates to drug delivery and specifically to the preparation and use of functionalized carriers such as nanopolymers and nanovesicles for improved delivery of nucleic acid agents (NAA) to tissues and cells. These compounds have broad applicability for treating numerous diseases and disorders, including neurodegenerative and neuromuscular disorders. The concept encompasses preferably polymeric carriers for delivery of a class of oligonucleotides that modulate RNA splicing.
    Type: Application
    Filed: January 2, 2007
    Publication date: January 8, 2009
    Applicant: Philadelphia Health & Education Corp., D/B/A/ Drexel University of College of Medicine
    Inventors: Gordon John Lutz, Margaret Alison Wheatley