Patents by Inventor Margaret Bynoe

Margaret Bynoe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of adenosine receptor signaling to regulate P-gp function
    Patent number: 10953015
    Abstract: The present invention relates to a method of inhibiting p-glycoprotein (P-gp) expression in a cell. The method involves contacting a cell expressing P-gp with a composition comprising an effective amount of an A2A adenosine receptor (A2A AR) agonist to inhibit P-gp expression in the cell. Methods of enhancing the bioavailability of a chemotherapeutic in a subject having multi-drug resistant (MDR) cancer and methods of increasing P-gp-mediated efflux in a cell are also disclosed.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: March 23, 2021
    Assignee: Cornell University
    Inventor: Margaret Bynoe
  • USE OF ADENOSINE RECEPTOR SIGNALING TO REGULATE P-GP FUNCTION
    Publication number: 20190038630
    Abstract: The present invention relates to a method of inhibiting p-glycoprotein (P-gp) expression in a cell. The method involves contacting a cell expressing P-gp with a composition comprising an effective amount of an A2A adenosine receptor (A2A AR) agonist to inhibit P-gp expression in the cell. Methods of enhancing the bioavailability of a chemotherapeutic in a subject having multi-drug resistant (MDR) cancer and methods of increasing P-gp-mediated efflux in a cell are also disclosed.
    Type: Application
    Filed: February 3, 2017
    Publication date: February 7, 2019
    Inventor: Margaret BYNOE
  • Compartmentalized trash and recyclable container
    Patent number: 7703622
    Abstract: Apparatus 10 discloses a compartmentalized waste and recyclable container 12. The compartmentalized container 12 is comprised of a divided waste container having removable receptacles 24, 26. One receptacle is designed for holding normal waste 26 while the other is designed for holding recyclables 24, such as cans, jars, plastic bottles, etc. The waste container has a sectioned lid 16, 17 providing access to either or both containers. The apparatus 10 also provides means whereby the container can be opened by a foot-operated mechanism 14, 15, relieving the user of having to have a free hand for access. Additionally, the container can incorporate wheels 18 for mobility and apertures 20 within the exterior wall. Each of the interior removable receptacles 24, 26 can also have handles 22 mounted thereto for ease of removing and carrying.
    Type: Grant
    Filed: January 25, 2005
    Date of Patent: April 27, 2010
    Inventor: Margaret Bynoe