Patents by Inventor Margaret Dah-Tsyr Chang
Margaret Dah-Tsyr Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9410969Abstract: The present invention provides a method of determining and treating amyotrophic lateral sclerosis (ALS) in a subject, comprising the following steps: (1) measuring a concentration of an autoantibody against high mobility group box 1 protein (HMGB1) in a biological sample from the subject; and (2) administering an effective amount of ALS-treating drug to the subject whose measured concentration of the autoantibody against HMGB1 is higher than 0.874 ?g/ml.Type: GrantFiled: September 15, 2015Date of Patent: August 9, 2016Assignees: National Tsing Hua University, China Medical UniversityInventors: Hao-Teng Chang, Margaret Dah-Tsyr Chang, Chi-Shin Hwang
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Patent number: 9328370Abstract: The present invention relates to a recombinant protein comprising SEQ ID NO: 1 and a bacteria recognizing lectin. The present invention also relates to uses of the recombinant protein comprising detecting pathogens, removing endotoxins, determining the presence of an endotoxin or endotoxin-like material, and determining the presence of pathogen-associated molecular pattern (PAMP) comprising rhamnose-rhamnose (Rha-Rha), rhamnose-N-acetyl-mannosamine (Rha-ManNAc), N-acetyl-mannosamine-rhamnose (ManNAc-Rha), rhamnose-galatose (Rha-Gal), or galatose-rhamnose (Gal-Rha) in a sample, and use as a medicament, a disinfectant, a decontaminant, a surfactant or a diagnostic means.Type: GrantFiled: May 13, 2014Date of Patent: May 3, 2016Assignee: SIMPSON BIOTECH CO., LTD.Inventors: Margaret Dah-Tsyr Chang, Chia-Chin Sheu
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Patent number: 9315544Abstract: A method of treating or preventing inflammatory related diseases in a subject in need thereof comprising administering to said subject a pharmaceutically effective amount of a composition comprising an immune modulating polypeptide of SEQ ID NO: 1 is provided. A method for inhibiting cancer metastasis or growth of tumor in a subject in need thereof, comprising administering to the subject a pharmaceutically effective amount of a composition comprising an immune modulating polypeptide of SEQ ID NO: 1 is also provided.Type: GrantFiled: September 10, 2013Date of Patent: April 19, 2016Assignee: National Tsing Hua UniversityInventors: Margaret Dah-Tsyr Chang, Lin-Shien Fu, Shun-Lung Fang
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Publication number: 20150377912Abstract: The present invention provides a method of determining and treating amyotrophic lateral sclerosis (ALS) in a subject, comprising the following steps: (1) measuring a concentration of an autoantibody against high mobility group box 1 protein (HMGB1) in a biological sample from the subject; and (2) administering an effective amount of ALS-treating drug to the subject whose measured concentration of the autoantibody against HMGB1 is higher than 0.874 ?g/ml.Type: ApplicationFiled: September 15, 2015Publication date: December 31, 2015Applicants: CHINA MEDICAL UNIVERSITY, NATIONAL TSING HUA UNIVERSITYInventors: HAO-TENG CHANG, MARGARET DAH-TSYR CHANG, CHI-SHIN HWANG
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Patent number: 9096880Abstract: The present invention relates to an isolated peptide consisting of the amino acid sequence of SEQ ID NO: 1. The present invention also relates to a method for increasing expression of a target protein using the peptide consisting of the amino acid sequence of SEQ ID NO: 1, comprising (a) fusing the peptide with the target protein to form a recombinant protein; and (b) expressing the recombinant protein by an expression host.Type: GrantFiled: May 13, 2014Date of Patent: August 4, 2015Assignee: NATIONAL TSING HUA UNIVERSITYInventor: Margaret Dah-Tsyr Chang
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Patent number: 8999688Abstract: A polysaccharide-protein binding model of SBD, and a fibril-forming 14-residue peptide consisting of X1NNNX2X3NYQX4X5X6X7X8, wherein the X1 and X8 mean a pair of opposite charged amino acid residues, and the X2, X3, X4, X5, X6, or X7 means an amino acid residue is described. A mixture for diminishing a polysaccharide, comprising at least two starch binding domains (SBDs) and a polysaccharide in a helix form is also presented. A method of providing an oligosaccharide, and a method of producing an amyloid-like fibril and use thereof are further described.Type: GrantFiled: January 19, 2011Date of Patent: April 7, 2015Assignee: National Tsing Hua UniversityInventors: Margaret Dah-Tsyr Chang, Yuh-Ju Sun, Ping-Chiang Lyu, Shu-Chuan Lin, Wei-I Chou
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Patent number: 8986955Abstract: The present invention provides a method and a system for increasing thermal stability of a target protein comprising fusing a starch binding protein (SBP) with the target protein to form a SBP-tagged recombinant protein and combining the SBP-tagged recombinant protein with a SBP-binding matrix. The present invention also provides a method for retaining an activity of a target protein in aquatic environment comprising fusing a starch binding protein (SBP) with the target protein to form a SBP-tagged recombinant protein and combining the SBP-tagged recombinant protein with a SBP-binding matrix.Type: GrantFiled: October 8, 2012Date of Patent: March 24, 2015Assignee: Simpson Biotech Co., Ltd.Inventors: Margaret Dah-Tsyr Chang, Chia-Chin Sheu
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Publication number: 20140342400Abstract: The present invention relates to an isolated peptide consisting of the amino acid sequence of SEQ ID NO: 1. The present invention also relates to a method for increasing expression of a target protein using the peptide consisting of the amino acid sequence of SEQ ID NO: 1, comprising (a) fusing the peptide with the target protein to form a recombinant protein; and (b) expressing the recombinant protein by an expression host.Type: ApplicationFiled: May 13, 2014Publication date: November 20, 2014Applicant: NATIONAL TSING HUA UNIVERSITYInventor: Margaret Dah-Tsyr Chang
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Publication number: 20140343250Abstract: The present invention relates to a recombinant protein comprising SEQ ID NO: 1 and a bacteria recognizing lectin. The present invention also relates to uses of the recombinant protein comprising detecting pathogens, removing endotoxins, determining the presence of an endotoxin or endotoxin-like material, and determining the presence of pathogen-associated molecular pattern (PAMP) comprising rhamnose-rhamnose (Rha-Rha), rhamnose-N-acetyl-mannosamine (Rha-ManNAc), N-acetyl-mannosamine-rhamnose (ManNAc-Rha), rhamnose-galatose (Rha-Gal), or galatose-rhamnose (Gal-Rha) in a sample, and use as a medicament, a disinfectant, a decontaminant, a surfactant or a diagnostic means.Type: ApplicationFiled: May 13, 2014Publication date: November 20, 2014Applicant: SIMPSON BIOTECH CO., LTD.Inventors: Margaret Dah-Tsyr Chang, Chia-Chin Sheu
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Publication number: 20140127723Abstract: The present invention provides a method of determining a risk for amyotrophic lateral sclerosis (ALS) in a subject, comprising the following steps: (1) measuring a concentration of an autoantibody against HMGB1 in a biological sample from the subject; and (2) comparing the measured concentration of the autoantibody against HMGB1 with a control value for autoantibody against HMGB1; wherein a difference between the measured concentration of the autoantibody against HMGB1 from the biological sample and the control value for autoantibody against HMGB1 is indicative of the risk of ALS in the subject.Type: ApplicationFiled: January 3, 2014Publication date: May 8, 2014Applicants: China Medical University, National Tsing Hua UniversityInventors: HAO-TENG CHANG, MARGARET DAH-TSYR CHANG, CHI-SHIN HWANG
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Publication number: 20140072574Abstract: A method of treating or preventing inflammatory related diseases in a subject in need thereof comprising administering to said subject a pharmaceutically effective amount of a composition comprising an immune modulating polypeptide of SEQ ID NO: 1 is provided. A method for inhibiting cancer metastasis or growth of tumor in a subject in need thereof, comprising administering to the subject a pharmaceutically effective amount of a composition comprising an immune modulating polypeptide of SEQ ID NO: 1 is also provided.Type: ApplicationFiled: September 10, 2013Publication date: March 13, 2014Applicant: National Tsing Hua UniversityInventors: Margaret Dah-Tsyr Chang, Lin-Shien Fu, Shun-Lung Fang
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Publication number: 20130315828Abstract: The present invention relates to a method of delivering an agent to a cancer cell, comprising: (a) obtaining a peptide that selectively binds to a cancer cell, wherein the peptide comprises a cancer targeting motif having the amino acid sequence of SEQ ID NO: 1, wherein the peptide is attached or fused to an agent that one desires to target to a cancer cell; and (b) exposing the peptide to a population of cells suspected of containing cancer cells. The present invention also relates to a kit for applying the above method, comprising a peptide that binds to a cancer cell, wherein the peptide comprises a cancer targeting motif having the amino acid sequence of SEQ ID NO: 1.Type: ApplicationFiled: May 23, 2012Publication date: November 28, 2013Applicant: NATIONAL TSING HUA UNIVERSITYInventors: Margaret Dah-Tsyr Chang, Shun-Lung Fang, Chien-Jung Chen
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Patent number: 8551695Abstract: The present invention provides a method for identifying starch binding sites of starch binding domain in CBM family. The CBM family is consisting of CBM20, CBM21, CBM25, CBM26, CBM34, and CBM41. The method further comprises predicting starch binding sites of starch binding domain in CBM family using the identified starch binding sites of starch binding domain with same topology.Type: GrantFiled: January 23, 2012Date of Patent: October 8, 2013Assignee: Simpson Biotech Co., Ltd.Inventors: Margaret Dah-Tsyr Chang, Ping-Chiang Lyu, Yuh-Ju Sun, Chia-Chin Sheu
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Patent number: 8399416Abstract: The present invention is for an isolated peptide consisting of the amino acid sequence of SEQ ID NO: 9 and using the peptide for treating asthma by reducing cytotoxicity of eosinophil derived toxins in bronchial epithelial cells of the subject suffers from asthma. The method comprises preparing a pharmaceutical composition having the peptide of SEQ ID NO: 9 and administering an effective amount of the composition to the subject.Type: GrantFiled: February 27, 2012Date of Patent: March 19, 2013Assignee: National Tsing Hua UniversityInventors: Margaret Dah-Tsyr Chang, Tan-chi Fan, Shu-Chuan Lin
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Patent number: 8372951Abstract: A cell penetrating peptide which has following sequence: NYBX1BX2BNQX3, wherein B represents a basic amino acid, X1 represents an amino acid with an aromatic, a hydrophobic or an uncharged side chain, X2 represents any amino acid, and X3 represents N or none is described. A method for delivering a cargo into a subject by administrating a complex comprising the cell penetrating peptide and the desired cargo to the subject is also described.Type: GrantFiled: May 14, 2010Date of Patent: February 12, 2013Assignee: National Tsing Hua UniversityInventors: Margaret Dah-Tsyr Chang, Shun-Lung Fang, Wei-I Chou, Shu-Chuan Lin
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Publication number: 20120322082Abstract: A diagnostic marker for determining of a patient with amyotrophic lateral sclerosis (ALS), comprising an autoantibody against a human protein HMGB1 is described. A diagnostic kit for determining of a patient with ALS, comprising: (a) an HMGB1 protein; and (b) an HMGB1 antibody standard is also presented. A method of determining ALS in a subject, comprising the steps: (a) detecting autoantibody against HMGB1 in a biological sample taken from the subject and normal control individuals; and (b) statistically comparing concentrations of the autoantibody against HMGB1 in the subject with that of the normal control individuals obtained from step (a); wherein a higher concentration of the autoantibody against HMGB1 in the subject than a cut-off concentration indicates the subject suffers from ALS is further described.Type: ApplicationFiled: June 20, 2011Publication date: December 20, 2012Applicants: China Medical University, National Tsing Hua UniversityInventors: Hao-Teng Chang, Margaret Dah-Tsyr Chang, Chi-Shin Hwang
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Patent number: 8293465Abstract: The present invention relates to an antibody mimetic of carbohydrate binding module (CBM) which specifically binds to an epitope on HIV glycoprotein. The present invention also relates to a method of detecting HIV glycoprotein.Type: GrantFiled: April 6, 2010Date of Patent: October 23, 2012Assignee: National Tsing Hua UniversityInventors: Margaret Dah-Tsyr Chang, Yuan-Chuan Lee, Rong-Yuan Huang, Shu-Chuan Lin, Wei-I Chou, Shi-Hwei Liu
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Publication number: 20120225492Abstract: The present invention provides a method for identifying starch binding sites of starch binding domain in CBM family. The CBM family is consisting of CBM20, CBM21, CBM25, CBM26, CBM34, and CBM41. The method further comprises predicting starch binding sites of starch binding domain in CBM family using the identified starch binding sites of starch binding domain with same topology.Type: ApplicationFiled: January 23, 2012Publication date: September 6, 2012Applicant: SIMPSON BIOTECH CO., LTD.Inventors: Margaret Dah-Tsyr Chang, Ping-Chiang Lyu, Yuh-Ju Sun, Chia-Chin Sheu
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Publication number: 20120214730Abstract: The present invention is for an isolated peptide consisting of the amino acid sequence of SEQ ID NO: 9 and using the peptide for treating asthma by reducing cytotoxicity of eosinophil derived toxins in bronchial epithelial cells of the subject suffers from asthma. The method comprises preparing a pharmaceutical composition having the peptide of SEQ ID NO: 9 and administering an effective amount of the composition to the subject.Type: ApplicationFiled: February 27, 2012Publication date: August 23, 2012Applicant: NATIONAL TSING HUA UNIVERSITYInventors: Margaret Dah-Tsyr Chang, Tan-chi Fan, Shu-Chuan Lin
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Publication number: 20110280798Abstract: The present invention provides a cell penetrating peptide which has following sequence: NYBX1BX2BNQX3, wherein B represents a basic amino acid, X1 represents an amino acid with an aromatic, a hydrophobic or an uncharged side chain, X2 represents any amino acid, and X3 represents N or none. The present invention also provides a method for delivering a cargo into a subject by administrating a complex comprising the cell penetrating peptide and the desired cargo to the subject.Type: ApplicationFiled: May 14, 2010Publication date: November 17, 2011Applicant: NATIONAL TSING HUA UNIVERSITYInventors: Margaret Dah-Tsyr Chang, Shun-Lung Fang, Wei-I Chou, Shu-Chuan Lin