Abstract: The invention relates to therapeutic uses of antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F in the treatment of dermatological and rheumatological diseases, such as psoriasis, psoriatic arthritis and axial spondyloarthritis.

Abstract: The invention relates to therapeutic uses of antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F in the treatment of dermatological and rheumatological diseases, such as psoriasis, psoriatic arthritis and axial spondyloarthritis.

Abstract: The invention relates to therapeutic uses of antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F in the treatment of dermatological and rheumatological diseases, such as psoriasis, psoriatic arthritis and axial spondyloarthritis.

Abstract: The invention relates to therapeutic uses of antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F in the treatment of dermatological and rheumatological diseases, such as psoriasis, psoriatic arthritis and axial spondyloarthritis.

Abstract: A reel assembly for a gaming machine includes an inner drive ring defining an annular inner rim, an outer ring, and a support substrate. The outer ring is spaced from and coaxially positioned relative to the inner drive ring, and the outer ring defines an annular outer rim. The support substrate has opposing side edges each coupled to a different one of the annular inner rim and the annular outer rim. The support substrate extends substantially unsupported between the annular inner rim and the annular outer rim in a substantially continuous manner maintaining the annular inner rim spaced from the annular out rim.

Abstract: A reel assembly for a gaming machine includes a central hub and a clip. The central hub defines an opening through an axial center of the central hub and includes two enclosed channels each positioned on an opposite side of the opening. Each of the two enclosed channels has an open end facing the opening. The clip includes a U-shaped main body and two opposing flanges. The U-shaped main body has opposing ends. The two opposing flanges each extend away from a different one of the opposing ends of the U-shaped main body. Each of the two opposing flanges of the clip fits through the open end of a different one of the two enclosed channels such that the clip is linearly slidable between the two enclosed channels while each of the two opposing flanges remains at least partially maintained with the corresponding different one of the two enclosed channels.

Abstract: A reel assembly for a gaming machine includes a central hub and a clip. The central hub defines an opening through an axial center of the central hub and includes two enclosed channels each positioned on an opposite side of the opening. Each of the two enclosed channels has an open end facing the opening. The clip includes a U-shaped main body and two opposing flanges. The U-shaped main body has opposing ends. The two opposing flanges each extend away from a different one of the opposing ends of the U-shaped main body. Each of the two opposing flanges of the clip fits through the open end of a different one of the two enclosed channels such that the clip is linearly slidable between the two enclosed channels while each of the two opposing flanges remains at least partially maintained with the corresponding different one of the two enclosed channels.

Abstract: A reel assembly for a gaming machine includes an inner drive ring defining an annular inner rim, an outer ring, and a support substrate. The outer ring is spaced from and coaxially positioned relative to the inner drive ring, and the outer ring defines an annular outer rim. The support substrate has opposing side edges each coupled to a different one of the annular inner rim and the annular outer rim. The support substrate extends substantially unsupported between the annular inner rim and the annular outer rim in a substantially continuous manner maintaining the annular inner rim spaced from the annular out rim.

Abstract: A nozzle in which an airfoil includes a pressure surface and a suction surface that join at substantially opposing chordal ends of the airfoil to form a leading edge of the airfoil and a trailing edge of the airfoil. A trailing edge passage is defined through the airfoil through which coolant flows. The trailing edge passage is proximate to the trailing edge of the airfoil and has a contoured shape that conforms to that of the trailing edge.

Abstract: A nozzle in which an airfoil includes a pressure surface and a suction surface that join at substantially opposing chordal ends of the airfoil to form a leading edge of the airfoil and a trailing edge of the airfoil. A trailing edge passage is defined through the airfoil through which coolant flows. The trailing edge passage is proximate to the trailing edge of the airfoil and has a contoured shape that conforms to that of the trailing edge.

Abstract: There is disclosed an isolated protein comprising (i) a winged helix motif which has the potential capability of binding to nucleic acid and (ii) a Cys2-His2 zinc finger motif which also has nucleic acid binding capability and nucleic acid molecules encoding therefor.

Abstract: A turbine stator vane includes outer and inner walls each having outer and inner chambers and a vane extending between the outer and inner walls. The vane includes first, second, third, fourth and fifth cavities for flowing a cooling medium. The cooling medium enters the outer chamber of the outer wall, flows through an impingement plate for impingement cooling of the outer band wall defining in part the hot gas path and through openings in the first, second and fourth cavities for flow radially inwardly, cooling the vane. The spent cooling medium flows into the inner wall and inner chamber for flow through an impingement plate radially outwardly to cool the inner wall. The spent cooling medium flows through the third cavity for egress from the turbine vane segment from the outer wall. The first, second or third cavities contain inserts having impingement openings for impingement cooling of the vane walls. The fifth cavity provides air cooling for the trailing edge.

Abstract: A guide tube is fixed adjacent opposite ends in outer and inner covers of a nozzle stage segment. The guide tube is serpentine in shape between the outer and inner covers and extends through a nozzle vane. An insert is disposed in the nozzle vane and has apertures to accommodate serpentine portions of the guide tube. Cooling steam is also supplied through chambers of the insert on opposite sides of a central insert chamber containing the guide tube. The opposite ends of the guide tube are fixed to sleeves, in turn fixed to the outer and inner covers.

Abstract: A post-cast EDM process is used to remove material from the interior surface of a nozzle vane cavity of a turbine. A thin electrode is passed through the cavity between opposite ends of the nozzle vane and displaced along the interior nozzle wall to remove the material along a predetermined path, thus reducing the thickness of the wall between the cavity and the external surface of the nozzle. In another form, an EDM process employing a profile as an electrode is disposed in the cavity and advanced against the wall to remove material from the wall until the final wall thickness is achieved, with the interior wall surface being complementary to the profile surface.

Abstract: A dispersion comprising an aqueous medium having dispersed therein an aggregated dye of the Formula (I): wherein X is oxygen or sulfur; R1-R4 each independently represent an unsubstituted or substituted alkyl group, an unsubstituted or substituted aryl group or an unsubstituted or substituted heteroaryl group; L1, L2 and L3 each independently represent substituted or unsubstituted methine groups; M+ represents a proton or an inorganic or organic cation; and n is 0, 1, 2 or 3 and wherein the aggregated dye in the dispersion has an absorption halfbandwidth of less than 55 nm.

Abstract: A guide tube is fixed adjacent opposite ends in outer and inner covers of a nozzle stage segment. The guide tube is serpentine in shape between the outer and inner covers and extends through a nozzle vane. An insert is disposed in the nozzle vane and has apertures to accommodate serpentine portions of the guide tube. Cooling steam is also supplied through chambers of the insert on opposite sides of a central insert chamber containing the guide tube. The opposite ends of the guide tube are fixed to sleeves, in turn fixed to the outer and inner covers.

Abstract: A dispersion comprising an aqueous medium having dispersed therein an aggregated dye of the Formula (I): 1

Abstract: A dispersion comprising an aqueous medium having dispersed therein an aggregated dye of the Formula (I): 1

Abstract: A dispersion comprising an aqueous medium having dispersed therein an aggregated dye of the Formula (I): wherein X is oxygen or sulfur; R1-R4 each independently represent an unsubstituted or substituted alkyl group, an unsubstituted or substituted aryl group or an unsubstituted or substituted heteroaryl group; L1, L2 and L3 each independently represent substituted or unsubstituted methine groups; M+ represents a proton or an inorganic or organic cation; and n is 0, 1, 2 or 3 and wherein the aggregated dye in the dispersion has an absorption half bandwidth of less than 55 nm.