Patents by Inventor Margaret K. Hostetter

Margaret K. Hostetter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody binding microbial heparin binding motif to retard or prevent microbial biofilm formation on implanted medical devices
    Patent number: 9920113
    Abstract: Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of microorganisms such as Candida species and/or Staphylococcus species.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: March 20, 2018
    Assignees: CHILDREN'S HOSPITAL MEDICAL CENTER, UNIVERSITY OF CINCINNATI, YALE UNIVERSITY
    Inventors: Margaret K. Hostetter, Long Lu, Julianne Vernadette Green, Alexey Porollo, Kris I. Orsborn, Khoon Ghee Queenie Tan, Kenneth Greis, David Andes
  • ANTIBODY BINDING MICROBIAL HEPARIN BINDING MOTIF TO RETARD OR PREVENT MICROBIAL BIOFILM FORMATION ON IMPLANTED MEDICAL DEVICES
    Publication number: 20160257734
    Abstract: Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of microorganisms such as Candida species and/or Staphylococcus species.
    Type: Application
    Filed: May 26, 2016
    Publication date: September 8, 2016
    Applicants: Children's Hospital Medical Center, University of Cincinnati, Yale University
    Inventors: Margaret K. Hostetter, Long Lu, Julianne Vernadette Green, Alexey Porollo, Kris I. Orsborn, Khoon Ghee Queenie Tan, Kenneth Greis, David Andes
  • Antibody binding microbial heparin binding motif to retard or prevent microbial biofilm formation on implanted medical devices
    Patent number: 9409975
    Abstract: Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of microorganisms such as Candida species and/or Staphylococcus species.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: August 9, 2016
    Assignees: Children's Hospital Medical Center, University of Cincinnati, Yale University
    Inventors: Margaret K. Hostetter, Long Lu, Julianne Vernadette Green, Alexey Porollo, Kris I. Orsborn, Khoon Ghee Queenie Tan, Kenneth Greis, David Andes
  • ANTIBODY BINDING MICROBIAL HEPARIN BINDING MOTIF TO RETARD OR PREVENT MICROBIAL BIOFILM FORMATION ON IMPLANTED MEDICAL DEVICES
    Publication number: 20150050284
    Abstract: Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of microorganisms such as Candida species and/or Staphylococcus species.
    Type: Application
    Filed: October 20, 2014
    Publication date: February 19, 2015
    Applicant: Children's Hospital Medical Center
    Inventors: Margaret K. Hostetter, Long Lu, Julianne Vernadette Green, Alexey Porollo, Kris I. Orsborn, Khoon Ghee Queenie Tan, Kenneth Greis, David Andes
  • Antibodies to the propeptide of and methods of use
    Patent number: 7138502
    Abstract: Antibodies and agents which can bind to the propeptide of the Int1p protein of yeast microorganisms such as Candida albicans are provided which can be useful in methods for treating or preventing infections arising from such microorganisms. Microorganisms expressing the Int1p protein, such as C. albicans and S. cerevisiae, have shown an ability to immunomodulate host cells which allows infections of these microorganisms to thrive and become virulent. The peptide regions involved in the activation of the Int1p protein are isolated and targeted so as to provide a method of disrupting activation and allow for treatment or prevention of infection by microorganisms expressing the int1p protein. In one preferred embodiment of the invention, an antibody or agent which can bind to the propeptide of the Int1p protein from C. albicans is utilized in methods to prevent or treat infections caused by C. albicans or other microorganisms expressing the Int1p protein.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: November 21, 2006
    Assignee: Yale University
    Inventors: Margaret K. Hostetter, Denise Devore-Carter
  • Candida albicans gene, integrin-like protein, antibodies, and methods of use
    Patent number: 6774219
    Abstract: An isolated and purified DNA molecule encoding Candida albicans protein with integrin-like motifs, the protein itself, antibodies thereto, and methods of use, are provided.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: August 10, 2004
    Assignee: Regents of the University of Minnesota
    Inventors: Margaret K. Hostetter, Cheryl A. Gale, Kathleen Kendrick
  • Human complement C3-binding protein from streptococcus pneumoniae
    Publication number: 20040062760
    Abstract: The present invention relates to the identification and use of a family of human complement C3-degrading proteinases expressed by S. pneumoniae. The proteinase has a molecular weight of about 24 kD to about 34 kD as determined on a 10% SDS polyacrylamide gel. A preferred proteinase of this invention includes the amino acid sequence of SEQ ID NO: 2.
    Type: Application
    Filed: October 9, 2003
    Publication date: April 1, 2004
    Applicant: Regents of the University of Minnesota
    Inventors: Margaret K. Hostetter, Gary M. Dunny, Lakshnmi S. Nandiwada
  • Human complement C3-degrading protein from Streptococcus pneumoniae
    Patent number: 6676943
    Abstract: The present invention relates to the identification and use of a family of human complement C3-degrading proteinases expressed by S. pneumoniae. The proteinase has a molecular weight of about 24 kD to about 34 kD as determined on a 10% SDS polyacrylamide gel. A preferred proteinase of this invention includes the amino acid sequence of SEQ ID NO:2.
    Type: Grant
    Filed: October 19, 1999
    Date of Patent: January 13, 2004
    Assignee: Regents of the University of Minnesota
    Inventors: Margaret K. Hostetter, Gary Dunny, Lakshmi S. Nandiwada
  • Antibodies to the propeptide of candida albicans and methods of use
    Publication number: 20030096975
    Abstract: Antibodies and agents which can bind to the propeptide of the Int1p protein of yeast microorganisms such as Candida albicans are provided which can be useful in methods for treating or preventing infections arising from such microorganisms. Microorganisms expressing the Int1p protein, such as C. albicans and S. cerevisiae, have shown an ability to immunomodulate host cells which allows infections of these microorganisms enhances to thrive and become virulent. In accordance with the present invention, peptide regions involved in the activation of the Int1p protein are isolated and targeted so as to provide a method of disrupting said activation and allow for treatment or prevention of infection by microorganisms expressing the int1p protein. In one preferred embodiment of the invention, an antibody or agent which can bind to the propeptide of the Int1p protein from C. albicans is utilized in methods to prevent or treat infections caused by C. albicans or other microorganisms expressing the Int1p protein.
    Type: Application
    Filed: September 28, 2001
    Publication date: May 22, 2003
    Inventors: Margaret K. Hostetter, Denise Devore-Carter
  • Candida albicans gene, integrin-like protein, antibodies, and methods of use
    Publication number: 20030082680
    Abstract: An isolated and purified DNA molecule encoding Candida albicans protein with integrin-like motifs, the protein itself, antibodies thereto, and methods of use, are provided.
    Type: Application
    Filed: October 15, 2001
    Publication date: May 1, 2003
    Applicant: Regents of the University of Minnesota
    Inventors: Margaret K. Hostetter, Cheryl A. Gale, Kathleen Kendrick
  • DNA encoding—candida albicans integrin-like protein
    Patent number: 6346411
    Abstract: An isolated and purified DNA molecule encoding Candida albicans protein with integrin-like motifs, the protein itself, antibodies thereto, and methods of use, are provided.
    Type: Grant
    Filed: March 8, 1999
    Date of Patent: February 12, 2002
    Assignee: Regents of the University of Minnesota
    Inventors: Margaret K. Hostetter, Cheryl A. Gale, Catherine M. Bendel, Nian-jun Tao
  • Method for isolating a C3 binding protein of streptococcus pneumoniae
    Patent number: 6291654
    Abstract: This invention relates to the identification of a human complement C3 binding protein from Streptococcus pneumoniae and to its sequence and to methods for its purification and use. The protein binds but does not degrade or cleave C3 and is implicated in S. pneumoniae virulence. The protein is recognized by antibodies produced by humans recovering from pneumococcal infection.
    Type: Grant
    Filed: May 12, 1999
    Date of Patent: September 18, 2001
    Assignee: Regents of the University of Minnesota
    Inventors: Margaret K. Hostetter, Qi Cheng
  • Candida albicans integrin-like protein
    Patent number: 5886151
    Abstract: An isolated and purified DNA molecule encoding Candida albicans protein with integrin-like motifs, the protein itself, antibodies thereto, and methods of use, are provided.
    Type: Grant
    Filed: May 3, 1996
    Date of Patent: March 23, 1999
    Assignee: Regents of the University of Minnesota
    Inventors: Margaret K. Hostetter, Cheryl A. Gale, Catherine M. Bendel, Nian-jun Tao, Kathleen Kendrick