Abstract: The disclosure provides antibodies that bind to forms of human transthyretin (TTR), monomer TTR specific antibodies, and methods of using the same.

Abstract: An example method for managing datasets produced by alert-triggering search queries may include producing a dataset by executing a search query on a portion of data associated with a time window defined relative to a current time. The method may further include responsive to determining that a portion of the dataset satisfies a condition defining an alert, generating an instance of the alert. The method may further include associating, by a memory data structure, the instance of the alert with an identifier of the query and a parameter specifying a time of execution of the query that has triggered the instance. The method may further include receiving a request for the dataset portion. The method may further include substituting, in a definition of the time window, the current time with the time parameter. The method may further include reproducing the dataset portion by re-executing the query using the time window.

Abstract: Systems, computer program products, and methods are described herein for assessing entity strategic impact using aggregated data sources. The method includes receiving at least one strategic impact indicator from each of at least two strategic impact data sources. The at least one strategic impact indicator relates to an entity strategic impact of an entity. The method also includes determining, via a machine learning model, a strategic impact confidence level for the entity. The strategic impact confidence level indicates a likelihood of an emerging strategic impact relating to the entity. The method further includes generating a strategic impact assessment report. The strategic impact assessment report indicates at least the strategic impact confidence level for the entity. The strategic impact assessment report also includes a strategic impact alert in an instance in which the strategic impact confidence level is below a threshold strategic impact level.

Abstract: The invention generally relates to the use of nuclear transport modulators, e.g., CRM1 inhibitors, of Formula (I) for treating epilepsy in a subject. Subjects can have unprovoked seizures without prior warning that affect one or both hemispheres of the brain. The disclosed methods can reduce the severity and occurrence of these unprovoked epileptic seizures and can result in resolution of epilepsy. The method comprises administering to the subject an effective amount of a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: A process for improving the searchability of incident-specific social media content posted via communication devices. In operation, an electronic computing device obtains incident information identifying an incident location and time of occurrence of the incident. The electronic computing device identifies a communication device located within a predetermined geographical area relative to the incident location during the time of occurrence of the incident. The electronic computing device then generates a concatenated string as a function of incident identifier associated with the incident and device identifier associated with the communication device and transmits an electronic message including the concatenated string to the communication device. The electronic message includes a link to enable the concatenated string to be attached to social media posts including incident-specific social media content posted via the communication device on social media networks.

Abstract: An example method for managing datasets produced by alert-triggering search queries may include producing a dataset by executing a search query on a portion of data associated with a time window defined relative to a current time. The method may further include responsive to determining that a portion of the dataset satisfies a condition defining an alert, generating an instance of the alert. The method may further include associating, by a memory data structure, the instance of the alert with an identifier of the query and a parameter specifying a time of execution of the query that has triggered the instance. The method may further include receiving a request for the dataset portion. The method may further include substituting, in a definition of the time window, the current time with the time parameter. The method may further include reproducing the dataset portion by re-executing the query using the time window.

Abstract: An example method for managing datasets produced by alert-triggering search queries may include producing a dataset by executing a search query on a portion of data associated with a time window defined relative to a current time. The method may further include responsive to determining that a portion of the dataset satisfies a condition defining an alert, generating an instance of the alert. The method may further include associating, by a memory data structure, the instance of the alert with an identifier of the query and a parameter specifying a time of execution of the query that has triggered the instance. The method may further include receiving a request for the dataset portion. The method may further include substituting, in a definition of the time window, the current time with the time parameter. The method may further include reproducing the dataset portion by re-executing the query using the time window.

Abstract: A process of identifying suspicious object movements in an incident location. An electronic computing device obtains incident information identifying a time of occurrence and a location of an incident. The electronic computing device identifies internet-of-things (IoT) devices deployed in the incident location and accesses received signal strength indication (RSSI) information associated with a selected IoT device. The RSSI information includes historical RSSI values that were captured at the IoT device during the time of occurrence of the incident. The electronic computing device generates a suspicious object movement pattern corresponding to the at least one IoT device based on variations within the historical RSSI values that were captured at the at least one IoT device during the first time period. A display or audio output device provides a corresponding visual or audio output indicating the suspicious object movement pattern corresponding to the IoT device.

Abstract: A process for improving the searchability of incident-specific social media content posted via communication devices. In operation, an electronic computing device obtains incident information identifying an incident location and time of occurrence of the incident. The electronic computing device identifies a communication device located within a predetermined geographical area relative to the incident location during the time of occurrence of the incident. The electronic computing device then generates a concatenated string as a function of incident identifier associated with the incident and device identifier associated with the communication device and transmits an electronic message including the concatenated string to the communication device. The electronic message includes a link to enable the concatenated string to be attached to social media posts including incident-specific social media content posted via the communication device on social media networks.

Abstract: A process of identifying suspicious object movements in an incident location. An electronic computing device obtains incident information identifying a time of occurrence and a location of an incident. The electronic computing device identifies internet-of-things (IoT) devices deployed in the incident location and accesses received signal strength indication (RSSI) information associated with a selected IoT device. The RSSI information includes historical RSSI values that were captured at the IoT device during the time of occurrence of the incident. The electronic computing device generates a suspicious object movement pattern corresponding to the at least one IoT device based on variations within the historical RSSI values that were captured at the at least one IoT device during the first time period. A display or audio output device provides a corresponding visual or audio output indicating the suspicious object movement pattern corresponding to the IoT device.

Abstract: An example method for managing datasets produced by alert-triggering search queries may include producing a dataset by executing a search query on a portion of data associated with a time window defined relative to a current time. The method may further include responsive to determining that a portion of the dataset satisfies a condition defining an alert, generating an instance of the alert. The method may further include associating, by a memory data structure, the instance of the alert with an identifier of the query and a parameter specifying a time of execution of the query that has triggered the instance. The method may further include receiving a request for the dataset portion. The method may further include substituting, in a definition of the time window, the current time with the time parameter. The method may further include reproducing the dataset portion by re-executing the query using the time window.

Abstract: An example method for managing datasets produced by alert-triggering search queries may include producing a dataset by executing a search query on a portion of data associated with a time window defined relative to a current time. The method may further include responsive to determining that a portion of the dataset satisfies a condition defining an alert, generating an instance of the alert. The method may further include associating, by a memory data structure, the instance of the alert with an identifier of the query and a parameter specifying a time of execution of the query that has triggered the instance. The method may further include receiving a request for the dataset portion. The method may further include substituting, in a definition of the time window, the current time with the time parameter. The method may further include reproducing the dataset portion by re-executing the query using the time window.

Abstract: The invention generally relates to the use of nuclear transport modulators, e.g., CRM1 inhibitors, of Formula (I) for treating epilepsy in a subject. Subjects can have unprovoked seizures without prior warning that affect one or both hemispheres of the brain. The disclosed methods can reduce the severity and occurrence of these unprovoked epileptic seizures and can result in resolution of epilepsy. The method comprises administering to the subject an effective amount of a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: An electronic communications device including a transceiver, a touch screen display, and an electronic processor and a method for controlling same. The method includes generating, with the electronic processor, a graphical user interface including a soft push-to-talk button and a call hang time indicator, indicating visually a call hang time, in proximity to the soft push-to-talk button. The method also includes displaying the graphical user interface on the touch screen display, receiving, from the touch screen display, a first input selecting the soft push-to-talk button, and, in response to receiving the first input, establishing a push-to-talk channel via the transceiver.

Abstract: An example method for managing datasets produced by alert-triggering search queries may include producing a dataset by executing a search query on a portion of data associated with a time window defined relative to a current time. The method may further include responsive to determining that a portion of the dataset satisfies a condition defining an alert, generating an instance of the alert. The method may further include associating, by a memory data structure, the instance of the alert with an identifier of the query and a parameter specifying a time of execution of the query that has triggered the instance. The method may further include receiving a request for the dataset portion. The method may further include substituting, in a definition of the time window, the current time with the time parameter. The method may further include reproducing the dataset portion by re-executing the query using the time window.

Abstract: Systems and methods for managing datasets produced by alert-triggering search queries in data aggregation and analysis systems. An example method may comprise: executing, by one or more processing devices, a search query on a portion of searchable data associated with a time window to produce a dataset comprising one or more results; responsive to determining that at least a portion of the dataset satisfies a triggering condition defining an alert associated with the search query, generating an instance of the alert; associating, by a memory data structure, the instance of the alert with an identifier of the search query and a time parameter specifying the time window; receiving, from a client computing device, a request for the portion of the dataset; and responsive to determining that the portion of the dataset is not stored in the memory in a manner associating it with the instance of the alert, reproducing the portion of the dataset by re-executing the search query in view of the time parameter.