Patents by Inventor Margaret M. Faul

Margaret M. Faul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for making substituted 2-amino-thiazolones
    Patent number: 8541593
    Abstract: The present invention relates to methods of making compounds that inhibit 11-hydroxysteroid dehydrogenase type 1 enzyme (11-HSD1). One method comprises (a) contacting a compound of formula (II) sequentially with a chiral base in the presence of an amine, and an alkylating agent R3-LG, (b) contacting the product of (a) with an acid to form a salt, and (c) reacting the salt with a base to form the compound of formula (I), wherein Z, R1, R2, and R3 are defined herein.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: September 24, 2013
    Assignee: Amgen Inc.
    Inventors: George A. Moniz, Matthew J. Frizzle, Charles Bernard, Michael Martinelli, Margaret M. Faul, Roger Nani, Jay Larrow
  • Synthesis of indolymaleimides
    Patent number: 6037475
    Abstract: The present invention provides a method for synthesizing indolylmaleimides by reacting an activated maleimide preferably with an optionally substituted organometalic-3-indole in the presence of a transition metal catalyst.
    Type: Grant
    Filed: February 11, 1999
    Date of Patent: March 14, 2000
    Assignee: Eli Lilly & Company
    Inventors: Margaret M. Faul, Michael R. Jirousek, John H. McDonald, III, David Andrew Neel
  • Synthesis of indolylmaleimides
    Patent number: 5919946
    Abstract: The present invention provides a method for synthesizing indolylmaleimides by reacting an activated maleimide preferably with an optionally substituted organometallic-3-indole in the presence of a transition metal catalyst.
    Type: Grant
    Filed: March 20, 1997
    Date of Patent: July 6, 1999
    Assignee: Eli Lilly and Company
    Inventors: Margaret M. Faul, Michael R. Jirousek, John H. McDonald, III, David Neel
  • Synthesis of indolylmaleimides
    Patent number: 5859261
    Abstract: The present invention provides a method for synthesizing indolylmaleimides by reacting an activated maleimide preferably with an optionally substituted organometallic-3-indole in the presence of a transition metal catalyst.
    Type: Grant
    Filed: December 19, 1997
    Date of Patent: January 12, 1999
    Assignee: Eli Lilly and Company
    Inventors: Margaret M. Faul, Michael R. Jirousek, John H. McDonald, III, David Andrew Neel
  • Synthesis of bisindolylmaleimides
    Patent number: 5665877
    Abstract: The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because it is stereoselective.
    Type: Grant
    Filed: May 17, 1996
    Date of Patent: September 9, 1997
    Assignee: Eli Lilly and Company
    Inventors: Margaret M. Faul, Michael R. Jirousek, Leonard L. Winneroski, II
  • Intermediates for the synthesis of bisindolylmaleimides
    Patent number: 5614647
    Abstract: The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because it is stereoselective.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: March 25, 1997
    Assignee: Eli Lilly and Company
    Inventors: Margaret M. Faul, Michael R. Jirousek, Leonard L. Winneroski, II
  • Synthesis of bisindolylmaleimides
    Patent number: 5541347
    Abstract: The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because it is stereoselective.
    Type: Grant
    Filed: October 3, 1994
    Date of Patent: July 30, 1996
    Assignee: Eli Lilly and Company
    Inventors: Margaret M. Faul, Michael R. Jirousek, Leonard L. Winneroski II