Abstract: Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.

Abstract: Mice, embryos, cells, and tissues having a restricted immunoglobulin heavy chain locus and an ectopic sequence encoding one or more ADAM6 proteins are provided. In various embodiments, mice are described that have humanized endogenous immunoglobulin heavy chain loci and are capable of expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof that is functional in a male mouse. Mice, embryos, cells, and tissues having an immunoglobulin heavy chain locus characterized by a single human VH gene segment, a plurality of human DH gene segments and a plurality of human JH gene segments and capable expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof are also provided.

Abstract: Aspects of the present disclosure include a system comprising a computer-readable storage medium storing at least one program and computer-implemented methods for providing suggestions of additional input to users entering user input into a data input field. In some embodiments, the method includes receiving initial user input entered via a data input field of a user interface rendered on a client device, and identifying a dominant category corresponding to the initial user input. The method further includes identifying a set of aspects corresponding to the dominant category, and selecting, from the set of aspects, a set of aspect suggestions based on a ranking of each aspect in the set of aspects. The method further includes causing display of a suggestion box presented in conjunction with the data input field. The suggestion box comprises a presentation of the set of aspect suggestions.

Abstract: Methods and systems are provided to refine search information. The methods and systems are for receiving a request from a mobile device, the request including an indication of a swiping motion that is applied across a touch-sensitive screen on the mobile device, the touch sensitive screen displaying search results including a first plurality of data items. The methods and systems are for retrieving a first refinement and a first value from a database entry. The methods and systems are for filtering the search results to generate refined search results including a second plurality of data items that are filtered based on the first refinement and the first value. The methods and systems are for communicating a user interface, over the network, to the mobile device, the communicating being responsive to the receiving the request, the user interface including the second plurality of data items for display on the mobile device.

Abstract: Methods and systems are provided to refine search information. The methods and systems are for receiving a request from a mobile device, the request including an indication of a swiping motion that is applied across a touch-sensitive screen on the mobile device, the touch sensitive screen displaying search results including a first plurality of data items. The methods and systems are for retrieving a first refinement and a first value from a database entry. The methods and systems are for filtering the search results to generate refined search results including a second plurality of data items that are filtered based on the first refinement and the first value. The methods and systems are for communicating a user interface, over the network, to the mobile device, the communicating being responsive to the receiving the request, the user interface including the second plurality of data items for display on the mobile device.

Abstract: Aspects of the present disclosure include a system comprising a computer-readable storage medium storing at least one program and computer-implemented methods for providing suggestions of additional input to users entering user input into a data input field. In some embodiments, the method includes receiving initial user input entered via a data input field of a user interface rendered on a client device, and identifying a dominant category corresponding to the initial user input. The method further includes identifying a set of aspects corresponding to the dominant category, and selecting, from the set of aspects, a set of aspect suggestions based on a ranking of each aspect in the set of aspects. The method further includes causing display of a suggestion box presented in conjunction with the data input field. The suggestion box comprises a presentation of the set of aspect suggestions.

Abstract: Methods and systems are provided to refine search information. The methods and systems are for receiving a request from a mobile device, the request including an indication of a swiping motion that is applied across a touch-sensitive screen on the mobile device, the touch sensitive screen displaying search results including a first plurality of data items. The methods and systems are for retrieving a first refinement and a first value from a database entry. The methods and systems are for filtering the search results to generate refined search results including a second plurality of data items that are filtered based on the first refinement and the first value. The methods and systems are for communicating a user interface, over the network, to the mobile device, the communicating being responsive to the receiving the request, the user interface including the second plurality of data items for display on the mobile device.

Abstract: Methods and systems to refine search results were described. The system communicates a first user interface to a mobile device that includes search results that include data items. The system receives a first request from the mobile device that includes an indication of at least one swiping motion that is applied across a touch-sensitive screen on the mobile device. The mobile device is associated with a previously selected refinement and corresponding value. The system filters the search results. The refined search results include a second plurality of data items based on the previously selected refinement and the corresponding value. The system generates a second user interface that includes the refined search results. The system communicates the second user interface, over the network, to the mobile device. The second user interface includes the refined search results that include the second plurality of data items to display on the mobile device.

Abstract: Methods and systems to refine search results were described. The system communicates a first user interface to a mobile device that includes search results that include data items. The system receives a first request from the mobile device that includes an indication of at least one swiping motion that is applied across a touch-sensitive screen on the mobile device. The mobile device is associated with a previously selected refinement and corresponding value. The system filters the search results. The refined search results include a second plurality of data items based on the previously selected refinement and the corresponding value. The system generates a second user interface that includes the refined search results. The system communicates the second user interface, over the network, to the mobile device. The second user interface includes the refined search results that include the second plurality of data items to display on the mobile device.