Patents by Inventor Margaret Magendantz

Margaret Magendantz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amyloid precursor-like protein and uses thereof
    Patent number: 5891991
    Abstract: The present invention is directed to isolated amyloid precursor-like proteins (APLPs), nucleotide sequences coding for and regulating expression of these protein, antibodies directed against these proteins, and recombinant vectors and host cells containing the genetic sequences coding for and regulating the expression of these protein sequences. The invention is also directed to isolated genomic. DNA, cDNA anti-sense RNA, and RNA containing the protein sequence. Antibodies can be used to detect an APLP in biological specimens, including, for example, fluid, serum or tissue samples. APLP1 and APLP2 are candidate genes for late onset familial Alzheimer's disease.
    Type: Grant
    Filed: August 6, 1996
    Date of Patent: April 6, 1999
    Assignees: The General Hospital Corporation, The Massachusetts Institute of Technology
    Inventors: Wilma Wasco, Keith Bupp, Margaret Magendantz, Rudolph Tanzi, Frank Solomon
  • Nucleic acid encoding amyloid precursor-like protein and uses thereof
    Patent number: 5851787
    Abstract: The present invention is directed to isolated amyloid precursor-like proteins (APLPs), nucleotide sequences coding for and regulating expression of these protein, antibodies directed against these proteins, and recombinant vectors and host cells containing the genetic sequences coding for and regulating the expression of these protein sequences. The invention is also directed to isolated genomic DNA, cDNA anti-sense RNA, and RNA containing the protein sequence. Antibodies can be used to detect an APLP in biological specimens, including, for example, fluid, serum or tissue samples. APLP1 and APLP2 are candidate genes for late onset familial Alzheimer's disease.
    Type: Grant
    Filed: January 21, 1993
    Date of Patent: December 22, 1998
    Assignees: The General Hospital Corporation, The Massachusetts Institute of Technology
    Inventors: Wilma Wasco, Keith Bupp, Margaret Magendantz, Rudolph Tanzi, Frank Solomon