Patents by Inventor Margaret Maria Zaleska

Margaret Maria Zaleska has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl)amino]alkyl]-acid derivatives for the treatment of pain
    Patent number: 7759346
    Abstract: This invention provides a method of treating pain in a mammal that includes administering to a mammal in need of such treatment a pain treating effective amount of a compound of the formula (I): where R1 is H, alkyl or phenylalkyl; R2 is H, alkyl, alkenyl or phenylalkyl; or R1 and R2 taken together as Z are —CH2C—H2—, —CH2C(R6)(R7)CH2— or —CH2C(R8)(R9)—C(R10)(R11)CH2—, where R6, R8 and R10 are, independently, H, alkyl or hydroxyl and R7, R9 and R11 are, independently, H or alkyl; A is alkylene or alkenylene; X is CO2R3, P(O)(OR4)(OR5), 3,5-dioxo-1,2,4-oxadiazolidin-2-yl or 5-tetrazolyl in which R3, R4 and R5 are, independently, H or alkyl, or a pharmaceutically acceptable salt thereof. The present invention also provides pharmaceutical compositions for treating pain containing a pain treating effective amount of the compound of formula (I).
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: July 20, 2010
    Assignee: Wyeth LLC
    Inventors: Michael Richard Brandt, Margaret Maria Zaleska, John Allen Moyer
  • Methods for Using Rapamycin Analogues in the Treatment of Neurological Disorders
    Publication number: 20090209527
    Abstract: The present invention provides methods for treatment of neurological disorders or complications due to stroke or head injury; benign or malignant neoplastic disease, carcinomas and adenocarcinomas; proliferative disorders; and inflammatory disorders, comprising administering a compound as described herein to a subject in need thereof, and a pharmaceutically acceptable carrier, within a therapeutic window that is from about 4 hours to 24 hours, or longer, for example at least 4, 6, 9, 12, 15, 18, 21 or 24 hours, or longer, after the onset of the neurological, proliferative, or inflammatory disorder or a symptom thereof.
    Type: Application
    Filed: February 19, 2009
    Publication date: August 20, 2009
    Applicant: Wyeth
    Inventors: Kevin Pong, Margaret Maria Zaleska
  • [[2-(Amino-3,4-dioxo-1-cyclobuten-1-yl)amino]alkyl]-acid derivatives for the treatment of pain
    Patent number: 7098200
    Abstract: This invention provides a method of treating pain in a mammal that includes administering to a mammal in need of such treatment a pain treating effective amount of a compound of the formula (I): where R1 is H, alkyl or phenylalkyl; R2 is H, alkyl, alkenyl or phenylalkyl; or R1 and R2 taken together as Z are —CH2CH2—, —CH2(CR6)(R7)CH2— or —CH2C(R8)(R9)—C(R10)(R11)CH2—, where R6, R8 and R10 are, independently, H, alkyl or hydroxyl and R7, R9 and R11 are, independently, H or alkyl; A is alkylene or alkenylene; X is CO2R3, P(O)(OR4)(OR5), 3,5-dioxo-1,2,4-oxadiazolidin-2-yl or 5-tetrazolyl in which R3, R4 and R5 are, independently, H or alkyl, or a pharmaceutically acceptable salt thereof. The present invention also provides pharmaceutical compositions for treating pain containing a pain treating effective amount of the compound of formula (I).
    Type: Grant
    Filed: October 9, 2002
    Date of Patent: August 29, 2006
    Assignee: Wyeth
    Inventors: Michael Richard Brandt, Margaret Maria Zaleska, John Allen Moyer
  • 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-alkoxy-3-quinolinecarbonitriles for the treatment of ischemic injury
    Publication number: 20040229880
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: February 18, 2004
    Publication date: November 18, 2004
    Applicant: Wyeth
    Inventors: Diane Harris Boschelli, Margaret Maria Zaleska, Frank Charles Boschelli, Kim Timothy Arndt
  • [[2-(Amino-3,4-dioxo-1-cyclobuten-1-yl)amino]alkyl]-acid derivatives for the treatment of pain
    Publication number: 20030114444
    Abstract: This invention provides a method of treating pain in a mammal that includes administering to a mammal in need of such treatment a pain treating effective amount of a compound of the formula (I): 1
    Type: Application
    Filed: October 9, 2002
    Publication date: June 19, 2003
    Applicant: Wyeth
    Inventors: Michael Richard Brandt, Margaret Maria Zaleska, John Allen Moyer