Patents by Inventor Margaret Mary Del Guidice

Margaret Mary Del Guidice has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Yeast-based process for production of l-pac
    Patent number: 6271008
    Abstract: This invention relates to yeast-mediated catalysis in organic solvents, and in particular the yeast-mediated condensation between pyruvate and a substituted aromatic aldehyde to yield the corresponding acyloin (hydroxy ketone) compound. The invention provides a method of synthesis of a substituted carbinol compound, comprising the step of subjecting the corresponding substituted aromatic aldehyde to acyloin condensation mediated by a yeast in an organic solvent under non-fermenting conditions. Preferably the yeast is Saccharomyces cerevisiae. In a preferred embodiment, the reaction is that between pyruvate and benzaldehyde to yield phenylacetylcarbinol, the precursor to ephedrine, to yield a product of high enantiomeric purity.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: August 7, 2001
    Assignees: Victoria University of Technology, Polychip Pharmaceuticals PTY LTD
    Inventors: Andrew John Smallridge, Maurice Arthur Trewhella, Margaret Mary Del Guidice