Patents by Inventor MARGARET MARY HURLEY

MARGARET MARY HURLEY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and use for surface display of proteins and peptide derivatives in a bacterial thermophile
    Patent number: 9605034
    Abstract: Provided are compositions are methods for discovery of new materials and interactions under extreme environmental conditions such as elevated temperatures at or in excess of 60° C. A synthetic thermostable protein is provided that is linked to a target peptide. A library of target peptides may be linked to a plurality of the thermostable proteins for expression on the cell surface of a thermophilic organism. The composition employs a modified form of the T. thermophilus TtoA protein that has a non-naturally occurring N-terminus for associating with a target peptide thereby expressing the target peptide on the outer cell membrane where the thermophilic protein is stable at high temperatures for discovery of materials useful in extreme environments or for us in study conditions that require or suffer under elevated temperatures.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: March 28, 2017
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Dimitra Nikolaos Stratis-Cullum, Bryn Lauren Adams, Margaret Mary Hurley
  • METHOD AND USE FOR SURFACE DISPLAY OF PROTEINS AND PEPTIDE DERIVATIVES IN A BACTERIAL THERMOPHILE
    Publication number: 20170058004
    Abstract: Provided are compositions are methods for discovery of new materials and interactions under extreme environmental conditions such as elevated temperatures at or in excess of 60° C. A synthetic thermostable protein is provided that is linked to a target peptide. A library of target peptides may be linked to a plurality of the thermostable proteins for expression on the cell surface of a thermophilic organism. The composition employs a modified form of the T. thermophilus TtoA protein that has a non-naturally occurring N-terminus for associating with a target peptide thereby expressing the target peptide on the outer cell membrane where the thermophilic protein is stable at high temperatures for discovery of materials useful in extreme environments or for us in study conditions that require or suffer under elevated temperatures.
    Type: Application
    Filed: August 28, 2015
    Publication date: March 2, 2017
    Applicant: THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE SECRETARY OF THE ARMY
    Inventors: Dimitra Nikolaos Stratis-Cullum, Bryn Lauren Adams, MARGARET MARY HURLEY