Patents by Inventor Margaret Nelson

Margaret Nelson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of anticoagulants in the production of recombinant proteins in the milk of transgenic animals
    Patent number: 9546381
    Abstract: The invention relates to the production of recombinant human fibrinogen (rhFib) in the milk of transgenic mammalian animals. This production and subsequent purification process is generally hampered by the occurrence of so-called ‘clots’ and ‘flakes’ in the milk which, in severe cases, may prevent the cow from being milked at all, resulting in a halt of lactation. These clots and flakes occur because of the expression of the fibrinogen protein, which is a factor that is normally involved in blood clotting. The invention relates to solving this milk clotting problem by treating the (lactating) animals with anticoagulants such as coumarins. A preferred anticoagulant that is used in the methods of the present invention is warfarin.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: January 17, 2017
    Assignee: PHARMING INTELLECTUAL PROPERTY BV
    Inventors: Kathryn Margaret Nelson, Michael William Mosesson, Anthony Pusateri, Erik Jordahl Forsberg
  • Energy production system using combustion exhaust
    Patent number: 8561390
    Abstract: An energy production and pressurized exhaust gas storage system including two combustion chambers aligned in opposition to each other, each of the two combustion chambers having a reciprocating power piston. A compression chamber is situated between the two combustion chambers and it includes a reciprocating compression piston. A shaft connects all of the pistons together. A solvent tank is connected to the two combustion chambers to receive the exhaust gas carbon dioxide. The solvent is preferably water maintained at about 32 degrees Fahrenheit and with a pressure above the water surface of about 100 pounds per square inch. Upon combustion, a pressurized carbon dioxide storage chamber receives compressed carbon dioxide from the compression chamber. Check valves are used to enable inflow of carbon dioxide to the compression chamber from the solvent tank and outflow of pressurized carbon dioxide in the compression chamber to storage.
    Type: Grant
    Filed: January 14, 2012
    Date of Patent: October 22, 2013
    Inventors: Rodney L. Nelson, Margaret A. Nelson, Durwood D. Woodall
  • Use of Anticoagulants in the Production of Recombinant Proteins in the Milk of Transgenic Animals
    Publication number: 20130053546
    Abstract: The invention relates to the production of recombinant human fibrinogen (rhFib) in the milk of transgenic mammalian animals. This production and subsequent purification process is generally hampered by the occurrence of so-called ‘clots’ and ‘flakes’ in the milk which, in severe cases, may prevent the cow from being milked at all, resulting in a halt of lactation. These clots and flakes occur because of the expression of the fibrinogen protein, which is a factor that is normally involved in blood clotting. The invention relates to solving this milk clotting problem by treating the (lactating) animals with anticoagulants such as coumarins. A preferred anticoagulant that is used in the methods of the present invention is warfarin.
    Type: Application
    Filed: March 11, 2011
    Publication date: February 28, 2013
    Applicant: PHARMING INTELLECTUAL PROPERTY BV
    Inventors: Kathryn Margaret Nelson, Michael William Mosesson, Anthony Pusateri, Erik Jordahl Forsberg
  • Energy production system using combustion exhaust
    Publication number: 20120186674
    Abstract: An energy production and pressurized exhaust gas storage system including two combustion chambers aligned in opposition to each other, each of the two combustion chambers having a reciprocating power piston. A compression chamber is situated between the two combustion chambers and it includes a reciprocating compression piston. A shaft connects all of the pistons together. A solvent tank is connected to the two combustion chambers to receive the exhaust gas carbon dioxide. The solvent is preferably water maintained at about 32 degrees Fahrenheit and with a pressure above the water surface of about 100 pounds per square inch. Upon combustion, a pressurized carbon dioxide storage chamber receives compressed carbon dioxide from the compression chamber. Check valves are used to enable inflow of carbon dioxide to the compression chamber from the solvent tank and outflow of pressurized carbon dioxide in the compression chamber to storage.
    Type: Application
    Filed: January 14, 2012
    Publication date: July 26, 2012
    Inventors: Rodney L. Nelson, Margaret A. Nelson, Durwood D. Woodall
  • Stroller
    Patent number: D332592
    Type: Grant
    Filed: February 19, 1991
    Date of Patent: January 19, 1993
    Assignee: Wheels and Things, Inc.
    Inventors: Michael D. O'Dea, Margaret Nelson