Abstract: Disclosed herein are systems and methods for continuously measuring a physiologic parameter of a patient, and can also include adjusting therapy based upon the physiologic parameter. The system can include a first probe having an elongate body, the probe configured to be inserted into a first location within a patient. At least one sensor can be operably connected to the first probe and configured to continuously provide real-time feedback information on one or more physiologic parameters at the first location within the patient, such as pH, pCO2, pO2, pressure, or temperature. A controller can be connected to the probe and configured to receive the real-time feedback information and to adjust a therapeutic setting on a therapeutic device based at least in part on the feedback information.