Abstract: Provided are methods of assigning a LAG+, LAG?, or PRO immunotype to a cancer patient based on the frequencies of LAG-3+CD8+T-cells, Ki67+CD8+T-cells, Tim-3+CD8+T-cells, and ICOS+CD8+T-cells in a peripheral blood sample from the patient, and selecting an anti-cancer therapy, for example, an immune checkpoint blockade (ICB) therapy, based on the patient's immunotype.

Abstract: A casino card game for a number of players which is played on a table which includes a station for the House and a number player stations adjacent thereto, each of which stations has positions for two pairs of cards and the player stations having a position for bet made by the player, the game being one in which each player is dealt four cards which the player has to make into two groups of two having a highest value, the value being achieved either by adding the face value of the cards, with the court card having a nominated face value of ten and disregarding the ten digit should there be one, each player playing against the bank, the player having a winning hand, if both of his pairs are higher than both of the bank pairs, a losing hand, if both is his pairs are lower than both of the bank's pairs and a stand-off, if one pair is lower and one pair is higher than the bank's pairs.