Abstract: The present application provides sulfonyl amide compounds, which are inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.

Abstract: The disclosure provides high strength high-entropy alloys with compositions (in atomic %) of FeaNibMncAldCreCf where 37-43 atomic %, b is 8-14 atomic %, c is 27-33 atomic %, d is 4-10 atomic %, e is 10-14 atomic %, and f is 0-2 atomic %.

Abstract: The disclosure provides high strength high-entropy alloys with compositions (in atomic %) of FeaNibMncAldCreCf where 37-43 atomic %, b is 8-14 atomic %, c is 27-33 atomic %, d is 4-10 atomic %, e is 10-14 atomic %, and f is 0-2 atomic %.

Abstract: Methods for identifying drug-saccharide conjugates that bind the mannose receptor, C type 1, (MRC1) and may be taken up by cells expressing MRC1, and the use of such drug-saccharide conjugates for treatment of particular diseases are described. In particular, the methods for identifying insulin-saccharide conjugates that bind the MRC1 receptor and may be taken up by cells expressing the MRC1 and use of such conjugates for treatment of diabetes are described.

Abstract: Methods for identifying drug-saccharide conjugates that bind the mannose receptor, C type 1, (MRC1) and may be taken up by cells expressing MRC1, and the use of such drug-saccharide conjugates for treatment of particular diseases are described. In particular, the methods for identifying insulin-saccharide conjugates that bind the MRC1 receptor and may be taken up by cells expressing the MRC1 and use of such conjugates for treatment of diabetes are described.

Abstract: A lubricant formulation and method of blending a lubricant formulation is disclosed. The lubricant formulation comprises at least two base stocks. The first base stock comprises a viscosity greater than 40 cSt, Kv100° C. and a tight molecular weight distribution as a function of viscosity. The second base stock comprises a viscosity less than 10 cSt, Kv100° C. The lubricant formulation provides favorable properties.

Abstract: An improved method is provided for removing contaminants from a hydrocarbon stream, such as a stream of raw natural gas. The contaminated hydrocarbon stream is passed through a first adsorbent bed containing molecular sieves to adsorb contaminants on the molecular sieves, thereby removing at least some of the contaminants from the hydrocarbon stream. The contaminated hydrocarbon stream may optionally be passed through a second adsorbent bed containing a desiccant material other than molecular sieves. The molecular sieves are regenerated using a wet regeneration process in which both the water content and temperature of the regeneration fluid stream are staged.

Abstract: An improved method is provided for removing contaminants from a hydrocarbon stream, such as a stream of raw natural gas. The contaminated hydrocarbon stream is passed through a first adsorbent bed containing molecular sieves to adsorb contaminants on the molecular sieves, thereby removing at least some of the contaminants from the hydrocarbon stream. The contaminated hydrocarbon stream may optionally be passed through a second adsorbent bed containing a desiccant material other than molecular sieves. The molecular sieves are regenerated using a wet regeneration process in which both the water content and temperature of the regeneration fluid stream are staged.

Abstract: A lubricant formulation and method of blending a lubricant formulation is disclosed. The lubricant formulation comprises at least two base stocks. The first base stock comprises a viscosity greater than 300 cSt, Kv100° C. and a tight molecular weight distribution as a function of viscosity. The second base stock comprises a viscosity less than 100 cSt, Kv100° C. The lubricant formulation provides favorable properties.

Abstract: A lubricant formulation and method of blending a lubricant formulation is disclosed. The lubricant formulation comprises at least two base stocks. The first base stock comprises a viscosity greater than 40 cSt, Kv100° C. and a tight molecular weight distribution as a function of viscosity. The second base stock comprises a viscosity less than 10 cSt, Kv100° C. The lubricant formulation provides favorable properties.

Abstract: The present invention is directed to a method for improving the performance of lubricating oils of high viscosity comprising GTL base stock(s) and/or base oil(s) and lubricating oil comprising such base stock(s) and/or base oil(s) in combination with an effective amount of a polyolefin fluid having a kinematic viscosity at 100° C. in the range between about 10 to about 200 mm2/s.

Abstract: Polyolefins made in accordance with the present invention are produced by polymerizing an unsaturated olefin or combination of unsaturated olefins to produce an unsaturated polyolefin, isomerizing the unsaturated polyolefin in the presence of an acid catalyst under conditions to produce a substantially unsaturated-isomerized polyolefin, and hydrogenating the unsaturated-isomerized polyolefin to produce a saturated isomerized polyolefin. A lube oil comprising the inventive saturated isomerized polyolefin is also disclosed.

Abstract: This invention relates to a process to produce a polyalpha-olefin comprising: 1) contacting one or more alpha-olefin monomers having 3 to 24 carbon atoms with an unbridged substituted bis cyclopentadienyl transition metal compound having: 1) at least one non-isoolefin substitution on both cyclopentadientyl rings, or 2) at least two substitutions on at least one cyclopentadienyl ring, a non-coordinating anion activator, and optionally an alkyl-aluminum compound, where the molar ratio of transition metal compound to activator is 10:1 to 0.1:1, and if the alkyl aluminum compound is present then the molar ratio of alkyl aluminum compound to transition metal compound is 1:4 to 4000:1, under polymerization conditions wherein: i) hydrogen is present at a partial pressure of 0.

Abstract: The invention relates to industrial lubricant and grease compositions containing high viscosity index polyalphaolefins (HVI-PAO). The use of HVI-PAOs in industrial oils and greases application provides advantages in improved shear stability, wear property, foam property, energy efficiency and improved overall performance.

Abstract: A fluid blend suitable for use as a lube basestock comprises two major components: (A) a copolymer made from ethylene with one or more alpha olefins, the copolymer (i) containing not more than 50 wt % ethylene; (ii) having a number average molecular weight of from 400 to 10,000; and (iii) a molecular weight distribution <3; and (B) a polyalphaolefin fluid or a hydroprocessed oil having a VI greater than 80.

Abstract: A liquid polymer suitable for use as a lubricant base oil is produced by polymerizing ethylene and at least one alpha-olefin using a metallocene catalyst to provide a polymer which is then isomerized and hydrogenated to produce the liquid polymer.

Abstract: A fluid blend suitable for use as a lube basestock comprises two major components: (A) a copolymer made from ethylene with one or more alpha olefins, the copolymer (i) containing not more than 50 wt % ethylene; (ii) having a number average molecular weight of from 400 to 10,000; and (iii) a molecular weight distribution <3; and (B) a polyalphaolefin fluid or a hydroprocessed oil having a VI greater than 80.

Abstract: This invention relates to alkylated methylnaphthalenes and their utility in lubricant base stocks. In particular, the alkylated methylnaphthalenes of the present invention have unexpectedly superior thermal and oxidative properties and may be used to improve the performance characteristics of other lubricant base oils.