Patents by Inventor Margarete Mehrabian

Margarete Mehrabian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis
    Patent number: 7241571
    Abstract: 5-LO is expressed in the monocyte/macrophages (mono/mac) and foam cells of atherosclerotic lesions and is differentially expressed in CAST and CON6 mice relative to B6 mice. Mice heterozygous for a null mutation of 5-LO, when placed on an LDLR?/? background, have dramatically reduced atherosclerosis as compared to control LDLR?/? mice. In a genetic epidemiologic study, it is found that a common 5-LO polymorphism is strongly associated with carotid artery intima-media thickness (IMT) and coronary artery disease patients. These results indicate that 5-LO and the leukotriene biosynthetic pathway is a major contributor to atherogenesis in animal models, and in atherosclerosis susceptibility in humans.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: July 10, 2007
    Assignee: The Regents of the University of California
    Inventors: Margarete Mehrabian, Aldons J. Lusis, Hooman Allayee
  • Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis
    Publication number: 20040209288
    Abstract: 5-LO is expressed in the monocyte/macrophages (mono/mac) and foam cells of atherosclerotic lesions and is differentially expressed in CAST and CON6 mice relative to B6 mice. Mice heterozygous for a null mutation of 5-LO, when placed on an LDLR−/− background, have dramatically reduced atherosclerosis as compared to control LDLR−/− mice. In a genetic epidemiologic study, it is found that a common 5-LO polymorphism is strongly associated with carotid artery intima-media thickness (IMT) and coronary artery disease patients. These results indicate that 5-LO and the leukotriene biosynthetic pathway is a major contributor to atherogenesis in animal models, and in atherosclerosis susceptibility in humans.
    Type: Application
    Filed: December 19, 2003
    Publication date: October 21, 2004
    Inventors: Margarete Mehrabian, Aldons J. Lusis, Hooman Allayee