Abstract: A novel gene defining a novel enzyme in the UDP-D-galactose: ?-N-acetylglucosamine / ?-N-acetylgalactosamine ?1,3galactosyltransferase family, termed ?3Gal-T5, with unique enzymatic properties is disclosed. The enzymatic activity of ?3Gal-T5 is shown to be distinct from that of previously identified enzymes of this gene family. The invention discloses isolated DNA molecules and DNA constructs encoding ?3Gal-T5 and derivatives thereof by way of amino acid deletion, substitution or insertion exhibiting ?3Gal-T5 activity, as well as cloning and expression vectors including such DNA, cells transfected with the vectors, and recombinant methods for providing ?3Gal-T5. The enzyme ?3Gal-T5 and ?3Gal-T5-active derivatives thereof are disclosed, in particular soluble derivatives comprising the catalytically active domain of ?3Gal-T5.

Abstract: A novel gene defining a novel enzyme in the UDP-D-galactose: beta-N-acetylglucosamine/beta-N-acetylgalactosamine beta 1,3galactosyltransferase family, termed beta3Gal-T5, with unique enzymatic properties is disclosed. The enzymatic activity of beta3Gal-T5 is shown to be distinct from that of previously identified enzymes of this gene family. The invention discloses isolated DNA molecules and DNA constructs encoding beta3Gal-T5 and derivatives thereof by way of amino acid deletion, substitution or insertion exhibiting beta3Gal-T5 activity, as well as cloning and expression vectors including such DNA, cells transfected with the vectors, and recombinant methods for providing beta3Gal-T5. The enzyme beta3Gal-T5 and beta3Gal-T5-active derivatives thereof are disclosed, in particular soluble derivatives comprising the catalytically active domain of beta3Gal-T5.

Abstract: A novel gene defining a novel enzyme in the UDP-D-galactose: ?-N-acetylglucosamine/?-N-acetylgalactosamine ?1,3galactosyltransferase family, termed ?3Gal-T5, with unique enzymatic properties is disclosed. The enzymatic activity of ?3Gal-T5 is shown to be distinct from that of previously identified enzymes of this gene family. The invention discloses isolated DNA molecules and DNA constructs encoding ?3Gal-T5 and derivatives thereof by way of amino acid deletion, substitution or insertion exhibiting ?3Gal-T5 activity, as well as cloning and expression vectors including such DNA, cells transfected with the vectors, and recombinant methods for providing ?3Gal-T5. The enzyme ?3Gal-T5 and ?3Gal-T5-active derivatives thereof are disclosed, in particular soluble derivatives comprising the catalytically active domain of ?3Gal-T5.

Abstract: A novel gene defining a novel enzyme in the UDP-D-galactose: &bgr;-N-acetylglucosamine/&bgr;-N-acetylgalactosamine &bgr;1,3galactosyltransferase family, termed &bgr;3Gal-T5, with unique enzymatic properties is disclosed. The enzymatic activity of &bgr;3Gal-T5 is shown to be distinct from that of previously identified enzymes of this gene family. The invention discloses isolated DNA molecules and DNA constructs encoding &bgr;3Gal-T5 and derivatives thereof by way of amino acid deletion, substitution or insertion exhibiting &bgr;3Gal-T5 activity, as well as cloning and expression vectors including such DNA, cells tranfected with the vectors, and recombinant methods for providing &bgr;3Gal-T5. The enzyme &bgr;3Gal-T5 and &bgr;3Gal-T5-active derivatives thereof are disclosed, in particular soluble derivatives comprising the catalytically active domain of &bgr;3Gal-T5.

Abstract: A novel gene defining a novel enzyme in the UDP-D-galactose: &bgr;-N-acetylglucosamine/&bgr;-N-acetylgalactosamine &bgr;1,3galactosyltransferase family, termed &bgr;3Gal-T5, with unique enzymatic properties is disclosed. The enzymatic activity of &bgr;3Gal-T5 is shown to be distinct from that of previously identified enzymes of this gene family. The invention discloses isolated DNA molecules and DNA constructs encoding &bgr;3Gal-T5 and derivatives thereof by way of amino acid deletion, substitution or insertion exhibiting &bgr;3Gal-T5 activity, as well as cloning and expression vectors including such DNA, cells tranfected with the vectors, and recombinant methods for providing &bgr;3Gal-T5. The enzyme &bgr;3Gal-T5 and &bgr;3Gal-T5-active derivatives thereof are disclosed, in particular soluble derivatives comprising the catalytically active domain of &bgr;3Gal-T5.