Patents by Inventor Margarita Bastos
Margarita Bastos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11311707Abstract: A fluid delivery device (100) comprising a housing (200) having a proximal end, a distal end, and a length therebetween, an activation device (300) disposed within the housing (200), a bottle (400) at least partially receivable in the proximal end of the housing (200), the bottle (400) containing a fluid medium therein and sealed by a laminate seal element, wherein the laminate seal element is proximate the activation device (300) and disposed a predetermined distance dimension therefrom, and a foam pad (500) coupled to a distal end of the housing (200), wherein the bottle (400) is axially movable with respect to the housing (200) at least the predetermined distance dimension to engage the laminate seal element with the activation device (300) to dispense the fluid medium from the bottle (400) through the foam pad. A method of using such a delivery device is provided.Type: GrantFiled: July 27, 2017Date of Patent: April 26, 2022Assignee: PROFESSIONAL DISPOSABLES INTERNATIONAL, INC.Inventors: Mark Follman, Alan Bachman, John Tanayan, Margarita Bastos
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Publication number: 20190209816Abstract: A fluid delivery device (100) comprising a housing (200) having a proximal end, a distal end, and a length therebetween, an activation device (300) disposed within the housing (200), a bottle (400) at least partially receivable in the proximal end of the housing (200), the bottle (400) containing a fluid medium therein and sealed by a laminate seal element, wherein the laminate seal element is proximate the activation device (300) and disposed a predetermined distance dimension therefrom, and a foam pad (500) coupled to a distal end of the housing (200), wherein the bottle (400) is axially movable with respect to the housing (200) at least the predetermined distance dimension to engage the laminate seal element with the activation device (300) to dispense the fluid medium from the bottle (400) through the foam pad. A method of using such a delivery device is provided.Type: ApplicationFiled: July 27, 2017Publication date: July 11, 2019Applicant: PROFESSIONAL DISPOSABLES INTERNATIONAL, INC.Inventors: Mark Follman, Alan Bachman, John Tanayan, Margarita Bastos
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Patent number: 8828926Abstract: Use of constructs which bind to one or more natriuretic peptide receptors and include a plurality of amino acid residues and at least one amino acid surrogate of formula I: where R, R?, Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group, for the prophylaxis or treatment of airway diseases, including but not limited to inflammation-related airway diseases, acute asthma or chronic obstructive pulmonary disease, methods of prophylaxis and treatment of airway diseases and pharmaceutical compositions and formulations for the prophylaxis or treatment of airway diseases.Type: GrantFiled: October 17, 2012Date of Patent: September 9, 2014Assignee: Palatin Technologies, Inc.Inventors: Margarita Bastos, Jennifer Lata, Jeffrey D. Edelson
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Patent number: 8580747Abstract: Cyclic constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues, at least one amino acid surrogate of formula I: where R, R?, Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group, pharmaceutical compositions including such cyclic constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti-hypertensive, cardiovascular, renal or endocrine effects are desired.Type: GrantFiled: November 19, 2009Date of Patent: November 12, 2013Assignee: Palatin Technologies, Inc.Inventors: Shubh D. Sharma, Margarita Bastos, Wei Yang, Hui-Zhi Cai
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Patent number: 8580746Abstract: Cyclic constructs which bind to a natriuretic peptide receptor and include a plurality of amino acid residues, at least one amino acid surrogate of formula I: where R, R?, Q, Y, W, Z, J, x and n are as defined in the specification, and a cyclic linkage including one or two amide bonds, pharmaceutical compositions including such cyclic constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti-hypertensive, cardiovascular, renal or endocrine effects are desired.Type: GrantFiled: October 2, 2009Date of Patent: November 12, 2013Assignee: Palatin Technologies, Inc.Inventors: Shubh D. Sharma, Margarita Bastos, Wei Yang
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Publication number: 20130274207Abstract: Use of constructs which bind to one or more natriuretic peptide receptors and include a plurality of amino acid residues and at least one amino acid surrogate of formula I: where R, R?, Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group, for the prophylaxis or treatment of airway diseases, including but not limited to inflammation-related airway diseases, acute asthma or COPD, methods of prophylaxis and treatment of airway diseases and pharmaceutical compositions and formulations for the prophylaxis or treatment of airway diseases.Type: ApplicationFiled: October 17, 2012Publication date: October 17, 2013Applicant: PALATIN TECHNOLOGIES, INC.Inventors: Margarita Bastos, Jennifer Lata, Jeffrey D. Edelson
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Patent number: 8114844Abstract: Linear and cyclic peptidomimetics which bind to one or more melanocortin receptors are provided, which peptidomimetics include at least one ring-constrained amino acid surrogate of formula I: where R1, R2, R3, R4, R5, R6, R7, R8, and y are as defined in the specification, together with methods for synthesizing ring-constrained amino acid surrogates of formula I and peptidomimetics incorporating the same, and methods of use of peptidomimetics in the treatment of various diseases, syndromes and conditions.Type: GrantFiled: October 3, 2008Date of Patent: February 14, 2012Assignee: Palatin Technologies, Inc.Inventors: Shubh D. Sharma, Margarita Bastos, Wei Yang
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Publication number: 20110263818Abstract: Peptidic constructs including at least one ring-constrained amino acid surrogate of formula I: where R1, R2, R3, R4, R5, R6a, R6b, R7, and y are as defined in the specification, and a plurality of amino acid residues.Type: ApplicationFiled: June 17, 2011Publication date: October 27, 2011Applicant: PALATIN TECHNOLOGIES, INC.Inventors: SHUBH D. SHARMA, MARGARITA BASTOS, WEI YANG, HUI-ZHI CAI
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Patent number: 7964181Abstract: Ring-constrained amino acid surrogates of formula I: where R1, R2, R3, R4, R5, R6a, R6b, R7, and y are as defined in the specification, methods for synthesizing ring-constrained amino acid surrogates of formula I, methods of use of ring-constrained amino acid surrogates of formula I, including use in linear or cyclic compounds which include a plurality of amino acid residues and one or more ring-constrained amino acid surrogates of formula I and linear or cyclic compounds which include a plurality of amino acid residues and one or more ring-constrained amino acid surrogates of formula I.Type: GrantFiled: March 30, 2007Date of Patent: June 21, 2011Assignee: Palatin Technologies, Inc.Inventors: Shubh D. Sharma, Margarita Bastos, Wei Yang, Hui-Zhi Cai
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Patent number: 7795221Abstract: Linear constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues and at least one amino acid surrogate of formula I: where R, R?, Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group covalently bound to a reactive group of at least one of the amino acid residues or surrogates, pharmaceutical compositions including such linear constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti-hypertensive, cardiovascular, renal or endocrine effects are desired.Type: GrantFiled: March 30, 2007Date of Patent: September 14, 2010Assignee: Palatin Technologies, Inc.Inventors: Shubh D. Sharma, Margarita Bastos, Wei Yang, Hui-Zhi Cai
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Publication number: 20100075895Abstract: Cyclic constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues, at least one amino acid surrogate of formula I: where R, R?, Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group, pharmaceutical compositions including such cyclic constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti-hypertensive, cardiovascular, renal or endocrine effects are desired.Type: ApplicationFiled: November 19, 2009Publication date: March 25, 2010Applicant: PALATIN TECHNOLOGIES, INC.Inventors: Shubh D. Sharma, Margarita Bastos, Wei Yang, Hui-Zhi Cai
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Publication number: 20100035821Abstract: Cyclic constructs which bind to a natriuretic peptide receptor and include a plurality of amino acid residues, at least one amino acid surrogate of formula I: where R, R?, Q, Y, W, Z, J, x and n are as defined in the specification, and a cyclic linkage including one or two amide bonds, pharmaceutical compositions including such cyclic constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti-hypertensive, cardiovascular, renal or endocrine effects are desired.Type: ApplicationFiled: October 2, 2009Publication date: February 11, 2010Applicant: PALATIN TECHNOLOGIES, INC.Inventors: Shubh D. Sharma, Margarita Bastos, Wei Yang
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Patent number: 7622440Abstract: Cyclic constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues, at least one amino acid surrogate of formula I: where R, R?, Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group, pharmaceutical compositions including such cyclic constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti-hypertensive, cardiovascular, renal or endocrine effects are desired.Type: GrantFiled: March 30, 2007Date of Patent: November 24, 2009Assignee: Palatin Technologies, Inc.Inventors: Shubh D. Sharma, Margarita Bastos, Wei Yang, Hui-Zhi Cai
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Publication number: 20090069224Abstract: Linear and cyclic peptidomimetics which bind to one or more melanocortin receptors are provided, which peptidomimetics include at least one ring-constrained amino acid surrogate of formula I: where R1, R2, R3, R4, R5, R6, R7, R8, and y are as defined in the specification, together with methods for synthesizing ring-constrained amino acid surrogates of formula I and peptidomimetics incorporating the same, and methods of use of peptidomimetics in the treatment of various diseases, syndromes and conditions.Type: ApplicationFiled: October 3, 2008Publication date: March 12, 2009Applicant: PALATIN TECHNOLOGIES, INC.Inventors: Shubh D. Sharma, Margarita Bastos, Wei Yang
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Publication number: 20080255033Abstract: Metallopeptides with a sequence of a biologically active gamma-melanocyte stimulating hormone sequence of length n residues, wherein a residue including a nitrogen atom and sulfur atom each available for complexation to a metal ion is inserted at any position from between the two and three position to the C-terminus side of the n position, or alternatively is substituted for the residue at any position from the three position to the n position, with a metal ion complexed thereto, with any proline (Pro) residue which is either of the two residues on the immediately adjacent N-terminus side of the inserted or substituent residue comprising a nitrogen atom and sulfur atom available for complexation to a metal ion is substituted with a homolog.Type: ApplicationFiled: June 10, 2008Publication date: October 16, 2008Applicant: PALATIN TECHNOLOGIES, INC.Inventors: Shubh D. Sharma, Yi-Qun Shi, Ramesh Rajpurohit, Hui-Zhi Cai, Margarita Bastos
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Patent number: 7385025Abstract: Metallopeptides with a sequence of a biologically active alpha-melanocyte stimulating hormone (?-MSH), gamma-melanocyte stimulating hormone (?-MSH), or bombesin sequence of length n residues, wherein a residue including a nitrogen atom and sulfur atom each available for complexation to a metal ion is inserted at any position from between the two and three position to the C-terminus side of the n position, or alternatively is substituted for the residue at any position from the three position to the n position, with a metal ion complexed thereto, with any proline (Pro) residue which is either of the two residues on the immediately adjacent N-terminus side of the inserted or substituent residue comprising a nitrogen atom and sulfur atom available for complexation to a metal ion is substituted with a homolog.Type: GrantFiled: July 25, 2005Date of Patent: June 10, 2008Assignee: Palatin Technologies, Inc.Inventors: Shubh D. Sharma, Yi-Qun Shi, Ramesh Rajpurohit, Hui-Zhi Cai, Margarita Bastos
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Patent number: 7351690Abstract: The invention provides methods for identification and determination of target-specific sites in peptides and proteins, including a method for determining the primary sequence of a secondary structure within a known parent polypeptide that binds to the target of interest. In one embodiment of the invention, a residue or mimetic containing a nitrogen atom and a sulfur atom available for binding to a metal ion is serially substituted for single residues in or inserted between adjacent residues in a known primary sequence of a peptide or protein. The resulting sequence is complexed with a metal ion thereby forming a metallopeptide. The resulting metallopeptides are then used in binding or functional assays related to the target of interest, and the metallopeptide(s) which result in significant or substantially decreased or changed binding or functionality are determined to identify the primary sequence involved in such binding or functionality.Type: GrantFiled: January 30, 2004Date of Patent: April 1, 2008Assignee: Palatin Technologies, Inc.Inventors: Shubh D. Sharma, Yi-Qun Shi, Margarita Bastos, Ramesh Rajpurohit, Hui-Zhi Cai
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Publication number: 20070287670Abstract: The present invention provides novel human glucagon-like peptide-1 (GLP-1) peptide mimics that mimic the biological activity of the native GLP-1 peptide and thus are useful for the treatment or prevention of diseases or disorders associated with GLP activity. Further, the present invention provides novel, chemically modified peptides that not only stimulate insulin secretion in type II diabetics, but also produce other beneficial insulinotropic responses. These synthetic peptide GLP-1 mimics exhibit increased stability to proteolytic cleavage making them ideal therapeutic candidates for oral or parenteral administration.Type: ApplicationFiled: April 25, 2007Publication date: December 13, 2007Inventors: Sesha Natarajan, Claudio Mapelli, Margarita Bastos, Michael Bernatowicz, Ving Lee, William Ewing
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Publication number: 20070265206Abstract: Cyclic constructs with an N-terminus and a C-terminus which bind to a natriuretic peptide receptor and include a plurality of amino acid residues, at least one amino acid surrogate of formula I: where R, R?, Q, Y, W, Z, J, x and n are as defined in the specification, and optionally at least one prosthetic group, pharmaceutical compositions including such cyclic constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti-hypertensive, cardiovascular, renal or endocrine effects are desired.Type: ApplicationFiled: March 30, 2007Publication date: November 15, 2007Applicant: PALATIN TECHNOLOGIES, INC.Inventors: Shubh Sharma, Margarita Bastos, Wei Yang, Hui-Zhi Cai
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Publication number: 20070260040Abstract: Ring-constrained amino acid surrogates of formula I: where R1, R2, R3, R4, R5, R6a, R6b, R7, and y are as defined in the specification, methods for synthesizing ring-constrained amino acid surrogates of formula I, methods of use of ring-constrained amino acid surrogates of formula I, including use in linear or cyclic compounds which include a plurality of amino acid residues and one or more ring-constrained amino acid surrogates of formula I and linear or cyclic compounds which include a plurality of amino acid residues and one or more ring-constrained amino acid surrogates of formula I.Type: ApplicationFiled: March 30, 2007Publication date: November 8, 2007Applicant: PALATIN TECHNOLOGIES, INC.Inventors: Shubh Sharma, Margarita Bastos, Wei Yang, Hui-Zhi Cai