Patents by Inventor Margarita DOMINGUEZ-VILLAR

Margarita DOMINGUEZ-VILLAR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods to activate or inhibit toll-like receptor signaling
    Patent number: 10308938
    Abstract: The present invention includes compositions and methods of inhibiting or activating TLR7 signaling. In one aspect, a composition includes an inhibitor of TLR7 signaling is described, where the inhibitor of TLR7 signaling is a TLR7 inhibitory oligonucleotide, a TLR7 antibody, or a TLR7 antagonist. In another aspect, a composition and method are described for preventing and treating viral infection of a T cell in a subject. Methods for decreasing T cell proliferation by administering a composition with a TLR7 ligand or agonist or inducing T cell anergy in a subject by stimulating T cells with a TLR7 ligand or agonist are also described.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: June 4, 2019
    Assignee: Yale University
    Inventors: Margarita Dominguez-Villar, David A. Hafler
  • COMPOSITIONS AND METHODS TO ACTIVATE OR INHIBIT TOLL-LIKE RECEPTOR SIGNALING
    Publication number: 20170130228
    Abstract: The present invention includes compositions and methods of inhibiting or activating TLR7 signaling. In one aspect, a composition includes an inhibitor of TLR7 signaling is described, where the inhibitor of TLR7 signaling is a TLR7 inhibitory oligonucleotide, a TLR7 antibody, or a TLR7 antagonist. In another aspect, a composition and method are described for preventing and treating viral infection of a T cell in a subject. Methods for decreasing T cell proliferation by administering a composition with a TLR7 ligand or agonist or inducing T cell anergy in a subject by stimulating T cells with a TLR7 ligand or agonist are also described.
    Type: Application
    Filed: June 18, 2015
    Publication date: May 11, 2017
    Inventors: Margarita DOMINGUEZ-VILLAR, David A. HAFLER