Patents by Inventor Margarita Gutova

Margarita Gutova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INTRANASALLY ADMINISTERED NEURAL STEM CELLS FOR TREATMENT OF TRAUMATIC BRAIN INJURIES
    Publication number: 20220354897
    Abstract: This disclosure relates to methods for treating a subject having a traumatic brain injury (TBI) by intranasal administration of neural stem cells (NSCs), while optionally providing environmental enrichment (EE) to the subject in conjunction with or in combination with the NSC administration.
    Type: Application
    Filed: May 9, 2022
    Publication date: November 10, 2022
    Applicants: CITY OF HOPE, UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Margarita GUTOVA, Anthony KLINE
  • TARGETING WNT SIGNALING FOR IMPROVED GLIOMA IMMUNOTHERAPY
    Publication number: 20220354852
    Abstract: This disclosure relates to cells that express a chimeric antigen receptor that targets IL13R?2 and/or HER2 and methods for treating a brain tumor by administering a population of cells expressing a chimeric antigen receptor that targets IL13R?2 and/or HER2 in combination with a Wnt/?-catenin pathway modulator to a subject having a brain tumor.
    Type: Application
    Filed: May 9, 2022
    Publication date: November 10, 2022
    Applicant: CITY OF HOPE
    Inventors: Margarita GUTOVA, Michael KAHN, Christine BROWN
  • L-MYC Expression Maintains Self Renewal and Prolongs Multipotency of Primary Human Neural Stem Cells
    Publication number: 20180092947
    Abstract: The invention provides isolated neural or mesenchymal stem cell populations which are genetically modified with an exogenous nucleic acid sequence encoding for a L-myc gene or its variant, wherein the L-myc gene or its variant is necessary and sufficient to immortalize the isolated neural or mesenchymal stem cell population.
    Type: Application
    Filed: August 17, 2017
    Publication date: April 5, 2018
    Inventor: Margarita Gutova
  • Identification and characterization of cancer stem cells and methods of use
    Patent number: 8569055
    Abstract: A subpopulation of cancer stem cells expressing elevated levels of uPAR have been identified among a population of cancer cells. Methods are provided for treating proliferative disorders such as cancer by administering one or more uPAR inhibitors. Methods are likewise provided for predicting the likelihood of recurrence of a cancer, preventing recurrence of a cancer, and identifying the likelihood of a cancer to respond to a particular cancer therapy.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: October 29, 2013
    Assignee: City of Hope
    Inventors: Margarita Gutova, Chu-Chih Shih, Anna Gevorgyan, Karen Aboody, Josip Najbauer
  • IDENTIFICATION AND CHARACTERIZATION OF CANCER STEM CELLS AND METHODS OF USE
    Publication number: 20110003386
    Abstract: A subpopulation of cancer stem cells expressing elevated levels of uPAR have been identified among a population of cancer cells. Methods are provided for treating proliferative disorders such as cancer by administering one or more uPAR inhibitors. Methods are likewise provided for predicting the likelihood of recurrence of a cancer, preventing recurrence of a cancer, and identifying the likelihood of a cancer to respond to a particular cancer therapy.
    Type: Application
    Filed: April 27, 2010
    Publication date: January 6, 2011
    Inventors: Margarita GUTOVA, Chu-Chih Shih, Anna Gevorgyan, Karen Aboody, Josip Najbauer
  • IDENTIFICATION AND CHARACTERIZATION OF CANCER STEM CELLS AND METHODS OF USE
    Publication number: 20070244046
    Abstract: A subpopulation of cancer stem cells expressing elevated levels of uPAR have been identified among a population of cancer cells. Methods are provided for treating proliferative disorders such as cancer by administering one or more uPAR inhibitors. Methods are likewise provided for predicting the likelihood of recurrence of a cancer, preventing recurrence of a cancer, and identifying the likelihood of a cancer to respond to a particular cancer therapy.
    Type: Application
    Filed: March 29, 2007
    Publication date: October 18, 2007
    Inventors: Margarita Gutova, Chu-Chih Shih, Anna Gevorgyan, Aboody Karen, Najbauer Josip