Abstract: A vaginal suppository system contains a formulation comprising active and inactive ingredients, which active ingredients may be nutraceuticals, herbs, vitamins, minerals and other bioactive agents. In an embodiment, the active ingredients comprise Oak gall, true unicorn root, bitter orange peel, tropical almond, heartsease, and zinc oxide. The formulation may be contained in a soluble encapsulation or a suspension for administration of the formulation in a vagina. A method of preparing a vaginal suppository system and a method of treating a vagina with a formulation comprising active and inactive ingredients are also disclosed.