Patents by Inventor Margery A. Connelly

Margery A. Connelly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS TO PREDICT LIVER DISEASE MORTALITY USING LIPOPROTEIN LP-Z
    Publication number: 20220011388
    Abstract: Described herein are methods for the determination of patient mortality from alcoholic hepatitis in biosamples by NMR spectroscopy and more specifically for the determination of a Z index score based on lipoprotein constituent LP-Z in blood plasma and serum.
    Type: Application
    Filed: November 7, 2019
    Publication date: January 13, 2022
    Inventors: Zhenghui Gordon Jiang, James D. Otvos, Irina Shalaurova, Elias J. Jeyarajah, Margery A. Connelly, Michael Curry, Nezam Afdhal, Yury Popov, Maria Perez-Matos
  • Monoacylglycerol lipase inhibitors for the treatment of metabolic diseases and related disorders
    Patent number: 9375430
    Abstract: Disclosed are compounds, compositions and methods for treating metabolic diseases, including obesity and diabetes. Such compounds are represented by formula (I) as follows: wherein Y and Z are defined herein.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: June 28, 2016
    Assignee: Janssen Pharmaceutica NV
    Inventors: Margery Connelly, Christopher M. Flores, Mark J. Macielag
  • Tricyclic indole derivatives useful endothelial lipase inhibitors
    Patent number: 9216998
    Abstract: The present invention is directed to tricyclic indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by endothelial lipase, for example, cardiovascular disorders.
    Type: Grant
    Filed: February 14, 2013
    Date of Patent: December 22, 2015
    Assignee: Janssen Pharmaceutica NV
    Inventors: Margery A. Connelly, Michael Greco, Hong Ye
  • Cell based screening assays for the triglyceride synthesis pathway
    Patent number: 9012159
    Abstract: A method for identifying a compound which modulates the activity of acyl-coA: diacylglycerol acyltransferase comprises the steps of contacting a stable isotope labeled fatty acid with cells in either presence or absence of the compound, extracting the cells with isopropyl alcohol, and determining the level of a stable isotope labeled triglyceride in the presence or absence of the compound; wherein a change in the level of the stable isotope labeled triglyceride indicates that the compound modulates the DGAT activity.
    Type: Grant
    Filed: January 7, 2010
    Date of Patent: April 21, 2015
    Assignee: Janssen Research & Development, LLC
    Inventors: Jian-Shen Qi, Wensheng Lang, Margery A. Connelly
  • Monoacylglycerol lipase inhibitors for the treatment of metabolic diseases and related disorders
    Patent number: 8987247
    Abstract: Disclosed are compounds, compositions and methods for treating metabolic diseases, including obesity and diabetes, and for reducing weight gain. Such compounds are represented by formula (I) as follows: wherein Y and Z are defined herein.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: March 24, 2015
    Assignee: Janssen Pharmaceutica NV
    Inventors: Margery Connelly, Christopher M. Flores, Mark J. Macielag
  • Animal model for evaluating vasomotor response in vivo
    Patent number: 8852556
    Abstract: A method for evaluating the effect of a compound on vasomotor response in vivo comprises the steps of administering said compound to a rabbit and measuring the diameter of the vessel lumen of a central ear artery of said rabbit in comparison with the baseline diameter of the vessel lumen of said central ear artery of said rabbit, said baseline diameter being measured prior to the administration of said compound.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: October 7, 2014
    Assignee: Janssen Research & Development LLC
    Inventors: Tom Jay Parry, Bruce P. Damiano, Edward C. Giardino, Margery A. Connelly
  • ?-ketoamide derivatives useful endothelial lipase inhibitors
    Patent number: 8476302
    Abstract: The present invention is directed to ?-ketoamide derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by endothelial lipase, for example, cardiovascular disorders.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: July 2, 2013
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Michael N. Greco, Margery A. Connelly, Shyamali Ghosh, Dennis J. Hlasta, Edward C. Lawson, Eric Strobel, Michele A. Weidner-Wells, Hong Ye
  • ALPHA-KETOAMIDE DERIVATIVES USEFUL ENDOTHELIAL LIPASE INHIBITORS
    Publication number: 20120077847
    Abstract: The present invention is directed to ?-ketoamide derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by endothelial lipase, for example, cardiovascular disorders.
    Type: Application
    Filed: September 26, 2011
    Publication date: March 29, 2012
    Inventors: Michael N. Greco, Margery A. Connelly, Shyamali Ghosh, Dennis J. Hlasta, Edward C. Lawson, Eric Strobel, Michele A. Weidner-Wells, Hong Ye
  • CELL BASED ASSAYS FOR THE TRIGLYCERIDE SYNTHESIS PATHWAY
    Publication number: 20100196930
    Abstract: A method for identifying a compound which modulates the activity of acyl-coA: diacylglycerol acyltransferase comprises the steps of contacting a stable isotope labeled fatty acid with cells in either presence or absence of the compound, extracting the cells with isopropyl alcohol, and determining the level of a stable isotope labeled triglyceride in the presence or absence of the compound; wherein a change in the level of the stable isotope labeled triglyceride indicates that the compound modulates the DGAT activity.
    Type: Application
    Filed: January 7, 2010
    Publication date: August 5, 2010
    Inventors: Jian-Shen Qi, Wensheng Lang, Margery A. Connelly
  • ANIMAL MODEL FOR EVALUATING VASOMOTOR RESPONSE IN VIVO
    Publication number: 20100189654
    Abstract: A method for evaluating the effect of a compound on vasomotor response in vivo comprises the steps of administering said compound to a rabbit and measuring the diameter of the vessel lumen of a central ear artery of said rabbit in comparison with the baseline diameter of the vessel lumen of said central ear artery of said rabbit, said baseline diameter being measured prior to the administration of said compound.
    Type: Application
    Filed: October 21, 2009
    Publication date: July 29, 2010
    Applicant: Johnson & Johnson Pharmaceutical Research & Development, LLC
    Inventors: Tom Jay Parry, Bruce P. Damiano, Edward C. Giardino, Margery A. Connelly
  • DNA-PK assay
    Patent number: 6803203
    Abstract: The present invention provides a method for detecting DNA-activated protein kinase (DNA-PK) activity in a biological sample.
    Type: Grant
    Filed: October 24, 2000
    Date of Patent: October 12, 2004
    Assignee: Brookhaven Science Associates
    Inventors: Carl W. Anderson, Margery A. Connelly
  • Biologically active alternative form of the IKK&agr; I&kgr;B kinase
    Patent number: 6803204
    Abstract: The present invention provides isolated I&kgr;B kinases that regulate NF&kgr;B gene transcription that lack both a leucine zipper like &agr;-helix domain and helix-loop-helix domain. Also provided are the amino acid sequences of these kinases and the nucleotide sequence encoding these kinases, and other related protein and nucleic acid molecules.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: October 12, 2004
    Assignee: The Research Foundation of State University of New York
    Inventors: Kenneth B. Marcu, Margery A. Connelly
  • Biologically active alternative form of the IKKalpha IkappaB kinase
    Publication number: 20030073111
    Abstract: The present invention provides isolated I&kgr;B kinases that regulate NF&kgr;B gene transcription that lack both a leucine zipper like &agr;-helix domain and helix-loop-helix domain. Also provided are the amino acid sequences of these kinases and the nucleotide sequence encoding these kinases, and other related protein and nucleic acid molecules.
    Type: Application
    Filed: July 3, 2002
    Publication date: April 17, 2003
    Inventors: Kenneth B. Marcu, Margery A. Connelly
  • Biologically active alternative form of the IKK&agr; I&kgr;B kinase
    Patent number: 6489151
    Abstract: The present invention provides isolated I&kgr;B kinases that regulate NF&kgr;B gene transcription that lack both a leucine zipper like &agr;-helix domain and helix-loop-helix domain. Also provided are the amino acid sequences of these kinases and the nucleotide sequence encoding these kinases, and other related protein and nucleic acid molecules.
    Type: Grant
    Filed: March 27, 2000
    Date of Patent: December 3, 2002
    Assignee: The Research Foundation of State University of New York
    Inventors: Kenneth B. Marcu, Margery A. Connelly