Patents by Inventor Margherita Morpurgo

Margherita Morpurgo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190160183
    Abstract: The present application describes compositions that can be used for the controlled release of pharmacological active ingredients from a viscoelastic aqueous polysaccharide matrix, and their potential use in the treatment of different stages of musculoskeletal diseases. The combination of drug release modulation and the viscoelastic nature of the composition makes possible the use thereof in the treatment of acute and chronic phases of musculoskeletal diseases characterized by an inflammatory state, and where a therapeutic effect and a viscosupplemental contribution are required.
    Type: Application
    Filed: July 18, 2017
    Publication date: May 30, 2019
    Applicant: JOINTHERAPEUTICS S.R.L.
    Inventors: Margherita Morpurgo, Giulio Bianchini, Lanfranco Callegaro
  • Publication number: 20180200376
    Abstract: Nanoassembled complexes of nucleic acids, avidin and biotinylated compounds functionalized to make them suitable for delivering and releasing drugs are described. These nanoassembled complexes consist of central poly-avidin nucleus, i.e. nucleus formed from the self-assembling of tetrameric avidin units on oligonucleotide sequences of nucleic acids, on which biotinylated compounds are further auto-assembled through high-affinity interactions between the avidin of the central nucleus and the biotin of the biotinylated compounds. The biotinylated compounds are functionalized so as to bind drugs with a reversible bond, allowing the delivery thereof and a controlled release.
    Type: Application
    Filed: July 8, 2016
    Publication date: July 19, 2018
    Inventor: Margherita MORPURGO
  • Patent number: 8486639
    Abstract: The present invention discloses new nanoassembled complexes consisting of a central nucleus formed by a high-affinity interaction from nucleic acids and avidin, wherein said nucleus is stabilized in aqueous solutions, even saline, and protected from further unspecific unwanted interactions by means of suitable polymeric agents capable to mask totally or partially the nucleus itself. The nanocomplexes obtained have been shown to be stable in aqueous solutions and to have nanoparticle features. In addition, the nano-complexes have shown characteristics useful for use in biotechnological field and in nanomedicine.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: July 16, 2013
    Assignee: ANANAS Nanotech S.r.L.
    Inventors: Margherita Morpurgo, Mauro Pignatto, Deborah Teoli
  • Publication number: 20100197032
    Abstract: The present invention discloses new nanoassembled complexes consisting of a central nucleus formed by a high-affinity interaction from nucleic acids and avidin, wherein said nucleus is stabilized in aqueous solutions, even saline, and protected from further unspecific unwanted interactions by means of suitable polymeric agents capable to mask totally or partially the nucleus itself. The nanocomplexes obtained have been shown to be stable in aqueous solutions and to have nanoparticle features. In addition, the nano-complexes have shown characteristics useful for use in biotechnological field and in nanomedicine.
    Type: Application
    Filed: June 27, 2008
    Publication date: August 5, 2010
    Inventors: Margherita Morpurgo, Mauro Pignatto, Deborah Teoli
  • Publication number: 20100112569
    Abstract: A microfluidic device comprising a substrate having formed therein microfluidic paths, at least a portion of the microfluidic paths having attached thereto a plurality of monolayers, wherein at least a portion of the monolayers comprises a photoactivatable group capable of generating a reactive group upon exposure to a light source, the reactive group being for binding a screenable moiety.
    Type: Application
    Filed: January 23, 2008
    Publication date: May 6, 2010
    Inventors: Roy Bar-Ziv, Amnon Buxboim, Margherita Morpurgo
  • Publication number: 20080305964
    Abstract: Novel compounds having a functionalized group capable of binding to a solid substrate; a photoactivatable group capable of generating a reactive group upon exposure to light and being for binding a screenable moiety; and a polymer capable of forming a monolayer on a solid substrate, and having the functionalized group and to the photoactivatable group attached thereto and processes for the preparation thereof are disclosed. Further disclosed are arrays of screenable moieties (e.g., nucleic acids, proteins, carbohydrates, substrates, chelating agents and many more) prepared using these novel compounds.
    Type: Application
    Filed: December 15, 2005
    Publication date: December 11, 2008
    Inventors: Roy Bar-Ziv, Margherita Morpurgo, Amnon Buxboim, Maya Bar-Dagan, Veronica Frydman, David Zbaida
  • Patent number: 7217575
    Abstract: A covalent conjugate of a 4?-hydroxyazobenzene-2-carboxylic acid derivative (HABA) and an avidin-type molecule, of the formula: wherein A is (CH2)n or —CH?CH—, wherein n is an integer from 0–10; B is (CH2)n wherein n is an integer from 2 to 10; m is zero or 1; and Av is the residue of an avidin-type molecule selected from the group comprising native egg-white avidin, recombinant avidin, deglycosylated avidins, bacterial streptavidin, recombinant streptavidin, truncated streptavidin and other derivatives of said avidin-type molecules. These HABAylated avidins are red colored in the quinone configuration and can be used in many applications in the avidin-biotin technology.
    Type: Grant
    Filed: July 23, 2003
    Date of Patent: May 15, 2007
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Meir Wilchek, Edward A Bayer, Heike Hofstetter, Margherita Morpurgo
  • Publication number: 20040191832
    Abstract: A covalent conjugate of a 4′-hydroxyazobenzene-2-carboxylic acid.
    Type: Application
    Filed: July 23, 2003
    Publication date: September 30, 2004
    Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: Meir Wilchek, Edward A. Bayer, Heike Hofstetter, Margherita Morpurgo
  • Publication number: 20040067229
    Abstract: A compound of the formula I 1
    Type: Application
    Filed: May 20, 2003
    Publication date: April 8, 2004
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Meir Wilchek, Edward A. Bayer, Heike Hofstetter, Margherita Morpurgo
  • Patent number: 6632929
    Abstract: A covalent conjugate of a 4′-hydroxyazobenzene-2-carboxylic acid derivative (HABA) and an avidin-type molecule, of the formula: wherein A is (CH2)n or —CH═CH—, wherein n is an integer from 0-10; B is (CH2)n wherein n is an integer from 2 to 10; m is zero or 1; and Av is the residue of an avidin-type molecule selected from the group comprising native egg-white avidin, recombinant avidin, deglycosylated avidins, bacterial streptavidin, recombinant streptavidin, truncated streptavidin and other derivatives of said avidin-type molecules. These HABAylated avidins are red colored in the quinone configuration and can be used in many applications in the avidin-biotin technology.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: October 14, 2003
    Assignee: Yeda Research and Development Co. LTD
    Inventors: Meir Wilchek, Edward A Bayer, Heike Hofstetter, Margherita Morpurgo
  • Patent number: 6602987
    Abstract: A compound of the formula I: wherein R is H or —N═N-2-carboxyphenyl; A is (CH2)n or —CH═CH—, wherein n is an integer from 0 to 10, or A may also be —CH(COOH)— when R is —N═N-2-carboxyphenyl; and X is a radical selected from the group consisting of: (i) Cl; (ii) COOR1, wherein R1 is p-nitrophenyl or N-succinimidyl; (iii) CONH—NHR2, wherein R2 is H, COO(t-butyl) or COObenzyl; (iv) CONH—[B]—NHR3, wherein R3 is H, COOR1, or CO—[B′]—maleimido, wherein R1 is t-butyl, p-nitrophenyl or N-succinimidyl, and B and B′, the same or different, are (CH2)n wherein n is an integer from 2 to 10; (v) CONH—[B]—COOR4, wherein R4 is H, C1-C8 alkyl, N-succinimidyl; (vi) CONH—[B]—OH; (vii) CONH—[B]—CONH—NHR2, wherein R2 is H, COO(t-butyl) or COObenzyl; and (viii) NHR2, wherein R2 is H, COO(t-butyl) or COObenzyl, when A is —CH(C
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: August 5, 2003
    Assignee: Yeda Research and Development Co., Ltd.
    Inventors: Meir Wilchek, Edward A. Bayer, Heike Hofstetter, Margherita Morpurgo