Patents by Inventor Margie L. Clapper

Margie L. Clapper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9101603
    Abstract: Methods for inhibiting the motility or proliferation of premalignant and malignant cells are provided. Methods for treating a malignancy of the head and neck and for treating a malignancy of the lung are also provided.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: August 11, 2015
    Assignee: Institute for Cancer Research
    Inventors: Margie L. Clapper, Ekaterina G. Shatalova, Sibele Meireles
  • Publication number: 20130251732
    Abstract: Methods for inhibiting the motility or proliferation of premalignant and malignant cells are provided. Methods for treating a malignancy of the head and neck and for treating a malignancy of the lung are also provided.
    Type: Application
    Filed: November 30, 2011
    Publication date: September 26, 2013
    Applicant: Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center ("Fox Chase
    Inventors: Margie L. Clapper, Ekaterina G. Shatalova, Sibele Meireles
  • Publication number: 20090215642
    Abstract: Compositions, kits, and methods are provided for assessing alterations in gene expression in heterozygous carriers of mutant genes associated with cancer.
    Type: Application
    Filed: December 11, 2006
    Publication date: August 27, 2009
    Inventors: Alfred G. Knudson, Alfonso Bellacosa, Margie L. Clapper, James A. Crowell, Levy Kopelovich
  • Patent number: 7452884
    Abstract: Novel methods for inhibiting angiogenesis and treating diseases associated with angiogenesis are described. The methods may comprise administering to a patient an effective amount of a 1,2-dithiol-3-thione derivative or metabolite thereof. Preferred compounds for use in the methods include 5-(2-pyrazinyl)-4methyl-1,2-dithiol-3-thione (Oltipraz) and its metabolites.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: November 18, 2008
    Assignee: Fox Chase Cancer Center
    Inventors: Bruce A. Ruggeri, Margie L. Clapper
  • Patent number: 7199122
    Abstract: Novel methods for inhibiting angiogenesis and treating diseases associated with angiogenesis are described. The methods may comprise administering to a patient an effective amount of a 1,2-dithiol-3-thione derivative or metabolite thereof. Preferred compounds for use in the methods include 5-(2-pyrazinyl)-4methyl-1,2-dithiol-3-thione (Oltipraz) and its metabolites.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: April 3, 2007
    Assignee: Fox Chase Cancer Center
    Inventors: Bruce A. Ruggeri, Margie L. Clapper
  • Publication number: 20030100564
    Abstract: Novel methods for inhibiting angiogenesis and treating diseases associated with angiogenesis are described. The methods may comprise administering to a patient an effective amount of a 1,2-dithiol-3-thione derivative or metabolite thereof. Preferred compounds for use in the methods include 5-(2-pyrazinyl)-4methyl-1, 2-dithiol-3-thione (Oltipraz) and its metabolites.
    Type: Application
    Filed: October 1, 2002
    Publication date: May 29, 2003
    Inventors: Bruce A. Ruggeri, Margie L. Clapper