Patents by Inventor Margie L. Clapper

Margie L. Clapper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Estrogen Metabolite Levels And Cancer Driver Gene Mutations In Lung Cancer Risk Stratification And Treatment
    Publication number: 20230033047
    Abstract: The present disclosure provides methods of risk stratification for the development of lung cancer and/or lung cancer recurrence, methods of treatment of a human having lung cancer with therapeutic agents for preventing estrogen metabolite production, and methods of treating a human having a high risk of developing lung cancer with therapeutic agents for preventing estrogen metabolite production.
    Type: Application
    Filed: January 11, 2021
    Publication date: February 2, 2023
    Inventors: Margie L. Clapper, Joseph N. Bodor, Jing Peng, Joseph Treat
  • Targeting of CYP1B1 in the treatment of head and neck cancer and lung cancer
    Patent number: 9101603
    Abstract: Methods for inhibiting the motility or proliferation of premalignant and malignant cells are provided. Methods for treating a malignancy of the head and neck and for treating a malignancy of the lung are also provided.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: August 11, 2015
    Assignee: Institute for Cancer Research
    Inventors: Margie L. Clapper, Ekaterina G. Shatalova, Sibele Meireles
  • TARGETING OF CYP1B1 IN THE TREATMENT OF HEAD AND NECK CANCER AND LUNG CANCER
    Publication number: 20130251732
    Abstract: Methods for inhibiting the motility or proliferation of premalignant and malignant cells are provided. Methods for treating a malignancy of the head and neck and for treating a malignancy of the lung are also provided.
    Type: Application
    Filed: November 30, 2011
    Publication date: September 26, 2013
    Applicant: Institute For Cancer Research d/b/a The Research Institute of Fox Chase Cancer Center ("Fox Chase
    Inventors: Margie L. Clapper, Ekaterina G. Shatalova, Sibele Meireles
  • Methods and Compositions for Assessing Alterations in Gene Expression Patterns in Clinically Normal Tissues Obtained from Heterozygous Carriers of Mutant Genes Associated with Cancer and Methods of Use Thereof
    Publication number: 20090215642
    Abstract: Compositions, kits, and methods are provided for assessing alterations in gene expression in heterozygous carriers of mutant genes associated with cancer.
    Type: Application
    Filed: December 11, 2006
    Publication date: August 27, 2009
    Inventors: Alfred G. Knudson, Alfonso Bellacosa, Margie L. Clapper, James A. Crowell, Levy Kopelovich
  • Methods for inhibiting angiogenesis
    Patent number: 7452884
    Abstract: Novel methods for inhibiting angiogenesis and treating diseases associated with angiogenesis are described. The methods may comprise administering to a patient an effective amount of a 1,2-dithiol-3-thione derivative or metabolite thereof. Preferred compounds for use in the methods include 5-(2-pyrazinyl)-4methyl-1,2-dithiol-3-thione (Oltipraz) and its metabolites.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: November 18, 2008
    Assignee: Fox Chase Cancer Center
    Inventors: Bruce A. Ruggeri, Margie L. Clapper
  • Methods for inhibiting angiogenesis
    Patent number: 7199122
    Abstract: Novel methods for inhibiting angiogenesis and treating diseases associated with angiogenesis are described. The methods may comprise administering to a patient an effective amount of a 1,2-dithiol-3-thione derivative or metabolite thereof. Preferred compounds for use in the methods include 5-(2-pyrazinyl)-4methyl-1,2-dithiol-3-thione (Oltipraz) and its metabolites.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: April 3, 2007
    Assignee: Fox Chase Cancer Center
    Inventors: Bruce A. Ruggeri, Margie L. Clapper
  • Novel methods for inhibiting angiogenesis
    Publication number: 20030100564
    Abstract: Novel methods for inhibiting angiogenesis and treating diseases associated with angiogenesis are described. The methods may comprise administering to a patient an effective amount of a 1,2-dithiol-3-thione derivative or metabolite thereof. Preferred compounds for use in the methods include 5-(2-pyrazinyl)-4methyl-1, 2-dithiol-3-thione (Oltipraz) and its metabolites.
    Type: Application
    Filed: October 1, 2002
    Publication date: May 29, 2003
    Inventors: Bruce A. Ruggeri, Margie L. Clapper