Patents by Inventor Margit A. Gayle

Margit A. Gayle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5576191
    Abstract: ST2 ligand polypeptides are provided, along with DNA sequences, expression vectors and transformed host cells useful in producing ST2 ligand polypeptides. The ST2 ligand polypeptide binds to a receptor that is expressed on cell types that include certain Hodgkin's Disease-derived tumor cells.
    Type: Grant
    Filed: June 17, 1994
    Date of Patent: November 19, 1996
    Assignee: Immunex Corporation
    Inventors: Margit Gayle, Jennifer L. Slack, Hans-Juergen Gruss, John E. Sims, Steven K. Dower
  • Patent number: 5314995
    Abstract: The present invention relates to antibody-based fusion proteins wherein a portion of an immunoglobulin molecule is linked to a biologically active ligand. In particular embodiments of the invention, the fusion protein comprises a portion of an antibody which recognizes a cell surface antigen linked to a ligand which is a lymphokine or a cellular factor. A preferred embodiment of the fusion protein comprises the variable region of the anti-tumor monoclonal antibody L6 and an active lymphokine molecule such as IL-2. In another preferred embodiment of the present invention, the fusion protein comprises the variable region of the L6 monoclonal antibody and active platelet factor 4. The antibody-based fusion proteins of the invention may be used therapeutically to deliver biologically active ligands to a specific target cell or tissue.
    Type: Grant
    Filed: January 22, 1990
    Date of Patent: May 24, 1994
    Assignee: Oncogen
    Inventors: Henry P. Fell, Jr., Margit A. Gayle