Patents by Inventor Margit Bidlo Nee Igloy
Margit Bidlo Nee Igloy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6750366Abstract: The present invention relates to a new microbial process for the preparation of the compound formula (I): from a compound of general formula (II): wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6&bgr;-hydroxylate a compound of the Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6&bgr;-hydroxylate a compound of the general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed.Type: GrantFiled: December 5, 2001Date of Patent: June 15, 2004Assignee: Institute for Drug Research Ltd.Inventors: Antonia Jekkel, Attila Konya, Istvan Barta, Eva Ilkoy, Gyorgy Somogyi, Gabor Ambrus, Gyula Horvath, Karoly Albrecht, Istvan Szabo, Julianna Mozes Nee Suto, Janso Salat, Attila Andor, Laszlo Birinesik, Sandor Boros, Ildiko Lang, Margit Bidlo Nee Igloy
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Publication number: 20040039225Abstract: The present invention relates to a new microbial process for the preparation of the compound formula (I) 1Type: ApplicationFiled: August 27, 2003Publication date: February 26, 2004Inventors: Antonia Jekkel, Attila Konya, Istvan Barta, Eva Ilkoy, Gyorgy Somogyi, Gabor Ambrus, Gyula Horvath, Karoly Albrecht, Istvan Szabo, Julianna Mozes Nee Suto, Janso Salat, Attila Andor, Laszlo Birincsik, Sandor Boros, Ildiko Lang, Margit Bidlo Nee Igloy
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Patent number: 6696599Abstract: The present invention relates to a new microbial process for the preparation of the compound formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6&bgr;-hydroxylate a compound of the Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6&bgr;-hydroxylate a compound of the general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed.Type: GrantFiled: May 14, 2003Date of Patent: February 24, 2004Assignee: Institute for Drug Research, Ltd.Inventors: Antonia Jekkel, Attila Konya, Istvan Barta, Eva Ilkoy, Gyorgy Somogyi, Gabor Ambrus, Gyula Horvath, Karoly Albrecht, Istvan Szabo, Julianna Mozes Nee Suto, Janso Salat, Attila Andor, Laszlo Birincsik, Sandor Boros, Ildiko Lang, Margit Bidlo Nee Igloy
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Patent number: 6682913Abstract: The present invention relates to a new microbial process for the preparation of the compound formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6&bgr;-hydroxylate a compound of the Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6&bgr;-hydroxylate a compound of the general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed.Type: GrantFiled: February 3, 2000Date of Patent: January 27, 2004Assignee: Institute for Drug Research Ltd.Inventors: Antonia Jekkel, Attila Konya, Istvan Barta, Eva Ilkoy, Gyorgy Somogyi, Gabor Ambrus, Gyula Horvath, Karoly Albrecht, Istvan Szabo, Julianna Mozes nee Suto, Janso Salat, Attila Andor, Laszlo Birincsik, Sandor Boros, Ildiko Lang, Margit Bidlo nee Igloy
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Publication number: 20030207413Abstract: The present invention relates to a new microbial process for the preparation of the compound formula (I) 1Type: ApplicationFiled: May 14, 2003Publication date: November 6, 2003Inventors: Antonia Jekkel, Attila Konya, Istvan Barta, Eva Ilkoy, Gyorgy Somogyi, Gabor Ambrus, Gyula Horvath, Karoly Albrecht, Istvan Szabo, Julianna Mozes Nee Suto, Janso Salat, Attila Andor, Laszlo Birincsik, Sandor Boros, Ilidiko Lang, Margit Bidlo Nee Igloy
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Publication number: 20020081675Abstract: The present invention relates to a new microbial process for the preparation of the compound formula (I) 1Type: ApplicationFiled: December 5, 2001Publication date: June 27, 2002Inventors: Antonia Jekkel, Attila Konya, Istvan Barta, Eva Ilkoy, Gyorgy Somogyi, Gabor Ambrus, Gyula Horvath, Karoly Albrecht, Istvan Szabo, Julianna Mozes Nee Suto, Janso Salat, Attila Andor, Laszlo Birinesik, Sandor Boros, Ildiko Lang, Margit Bidlo Nee Igloy
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Patent number: 6248907Abstract: The invention relates to R-2-[3-([1,4]benzodioxan-2-ylmethylamino)-1-propyl]-3(2H)-pyridazinone of formula (1), and to S-2-[3-([1,4]benzodioxan-2-ylmethylamino)-1-propyl]-3(2H)-pyridazinone of formula (2), and to acid-addition salts thereof as well as pharmaceutical compositions containing these compounds. Furthermore, the invention relates to a process for the preparation of the above compounds. The new starting compounds of formulae (4) and (5) are also involved in the scope of the invention. The compounds according to the invention possess &agr;1- and &agr;2-adrenoceptor antagonistic effects and urogenital selectivity. Thus, they are useful for the treatment of the benign prostate hyperplasia.Type: GrantFiled: August 28, 2000Date of Patent: June 19, 2001Assignee: Gyogyszerkutato Intezet Kft.Inventors: Péter Mátyus, László Hársing, Marianne Tapfer née Karim, Judit Kosáry, Ágnes Papp née Behr, Antal Simay, Yemane Tilahun, Éva Tomori née Joszt, Edit Horváth, Katalin Horváth, Ildikó Varga, Erzsébet Zára née Kaczián, Margit Bidló née Iglóy, Alice Druga, György Rabloczky, Márta Varga, Egon Kárpáti, Endre Kasztreiner, István Király, Ildikó Máthé née Gyóry, György Máthé, László Sebestyén, Nándor Makk
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Patent number: 6245921Abstract: A process for the isolation of the pseudomonic acid A antibiotic of pharmaceutical quality from the culture broth of one of the pseudomonic acid A-producing species of the Pseudomonas bacterium genus comprising the extraction of the biosynthesized pseudomonic acid A from the culture broth at acidic pH with a chlorinated aliphatic hydrocarbon or isobutyl acetate, followed by purification, is disclosed.Type: GrantFiled: February 3, 2000Date of Patent: June 12, 2001Assignee: Biogal Gyogyszergyar Rt.Inventors: Istvan Barta, Aniko Tegdes, Valeria Szell, Csaba Szabo, Edit Nagy Nee Arvai, Vilmos Keri, David Leonov, IIdiko Lang, Margit Bidlo Nee Igloy, Gyula Jerkovich, Janos Salat
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Patent number: 4579954Abstract: The invention relates to the new monohydrate of N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N"-cyanoguanidi ne (cimetidine), a histamine-H.sub.2 receptor antagonist which is called N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N"-cyanoguanidi ne H (cimetidine H) as well as to a process for the preparation of same, which comprises pouring a hot, homogeneous aqueous solution of N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N"-cyanoguanidi ne, optionally containing also methylamine, onto ice and separating the N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N"-cyanoguanidi ne monohydrate.Type: GrantFiled: April 27, 1984Date of Patent: April 1, 1986Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Kalman Harsanyi, Gyorgy Domany, Oszkar Fuchs, Lajos Toldy, Gyorgy Fekete, Endre Kasztreiner, Bela Hegedus, Ferenc Morasz, Andras Rado, Tibor Lang, Arpad Lazar, Eva Csongor, Tibor Balogh, Janos Borvendeg, Jozsef Reiter, Tibor Somogyi, Margit Bidlo nee Igloy