Patents by Inventor Margot Mary O'Toole

Margot Mary O'Toole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Gene Expression Profiles Associated with Asthma Exacerbation Attacks
    Publication number: 20090325176
    Abstract: The present invention provides methods for the assessment, diagnosis, or prognosis of asthma exacerbation, by assessing the level of expression of asthma exacerbation gene products in a sample derived from a patient. The markers of the present invention can be used in methods to identify or evaluate agents capable of modulating marker expression levels in subjects with asthma.
    Type: Application
    Filed: June 5, 2009
    Publication date: December 31, 2009
    Applicant: Wyeth
    Inventors: Margot Mary O'Toole, Frederick William Immermann, Padmalatha Sunkara Reddy, Andrew Arthur Hill, John Louis Ryan, Andrew Joseph Dorner, Cristina Ileana Csimma, Charlotte Marie McKee, Wei Liu, Divya Chaudhary, Matthew Ren Silver
  • ASSESSMENT OF ASTHMA AND ALLERGEN-DEPENDENT GENE EXPRESSION
    Publication number: 20090155784
    Abstract: The present invention provides methods for the assessment, diagnosis, or prognosis of asthma including methods for providing an assessment, diagnosis, or prognosis comprising the step of exposing a sample derived from a patient to an allergen in vitro. The present invention also provides methods for selecting, as well as evaluating the effectiveness of, asthma treatments.
    Type: Application
    Filed: January 21, 2008
    Publication date: June 18, 2009
    Applicant: Wyeth
    Inventors: Margot Mary O'Toole, Frederick William Immermann, Andrew Joseph Dorner, Padmalatha Sunkara Reddy, Holly Marie Legault, Kerry Ann Whalen
  • Methods and compositions for assessment and treatment of asthma
    Publication number: 20080226645
    Abstract: The present invention provides methods and compositions for the assessment and treatment of asthma and other inflammatory diseases, particularly those mediated by interleukin-13 (IL-13). The present invention also provides arrays comprising markers for asthma as well as IL-13 responsiveness. The markers of the present invention can be used in methods to diagnose a patient as having asthma or an IL-13-mediated condition, to evaluate the effectiveness of potential therapeutic agents, to identify or evaluate agents capable of modulating marker expression levels, and to select a treatment for a patient suffering from asthma or an IL-13-mediated condition.
    Type: Application
    Filed: January 10, 2008
    Publication date: September 18, 2008
    Applicant: Wyeth
    Inventors: Margot Mary O'Toole, Frederick William Immermann, Andrew Arthur Hill, Padmalatha Sunkara Reddy, Michael Edward Burczynski, Douglas Kenneth Miller, Karl Henry Nocka, Stanley Francis Wolf, Michael Ronald Bowman, Andrew Joseph Dorner, I-Ming Wang
  • Compositions and methods for diagnosing and treating autoimmune diseases
    Publication number: 20040191818
    Abstract: Compositions and methods for diagnosing, preventing, or treating lupus nephritis (LN), systemic lupus erythematosus (SLE), or other autoimmune diseases. Lupus-related genes (LRGs) are identified in the present invention. These genes are differentially expressed in lupus-affected or lupus-predisposed tissues as compared to disease-free tissues. The genes and their expression products can be used as markers for diagnosing or monitoring SLE or LN. Modulators of the expression or protein activities of these genes can be used for the prevention or treatment of SLE/LN or other autoimmune diseases.
    Type: Application
    Filed: February 26, 2004
    Publication date: September 30, 2004
    Inventors: Margot Mary O'Toole, Wei Liu