Patents by Inventor Margrit Schwarz

Margrit Schwarz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONJUGATES AND METHODS FOR TREATING LIVER FIBROSIS
    Publication number: 20220387600
    Abstract: Provided herein are certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to treat certain diseases, such as liver fibrosis, e.g., in the setting of NASH or ASH.
    Type: Application
    Filed: December 7, 2020
    Publication date: December 8, 2022
    Applicant: GENEVANT SCIENCES GMBH
    Inventors: James HEYES, Richard J. HOLLAND, Mark WOOD, Alan D. MARTIN, Christine ESAU, Margrit SCHWARZ, Xin YE, Alice Hoy Lam LI, Christopher Justin PASETKA, David CROWE, Steven TYLER
  • CONJUGATES AND METHODS FOR TREATING ACROMEGALY
    Publication number: 20220288214
    Abstract: Provided herein are certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. He conjugates are useful to treat certain diseases, such as acromegaly.
    Type: Application
    Filed: October 23, 2020
    Publication date: September 15, 2022
    Applicant: GENEVANT SCIENCES GMBH
    Inventors: Drew KONDRATOWICZ, James HEYES, Richard J. HOLLAND, Christine ESAU, Kevin MCCLINTOCK, Christopher Justin PASETKA, Mark WOOD, Alan D. MARTIN, Margrit SCHWARZ, David CROWE, Steven TYLER
  • Modified lecithin-cholesterol acyltransferase enzymes
    Patent number: 9006408
    Abstract: The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: April 14, 2015
    Assignee: Amgen Inc.
    Inventors: Mingyue Zhou, Wenyan Shen, Bei Shan, Margrit Schwarz, David Park Meininger, Tom Boone
  • MODIFIED LECITHIN-CHOLESTEROL ACYLTRANSFERASE ENZYMES
    Publication number: 20140287479
    Abstract: The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.
    Type: Application
    Filed: March 4, 2014
    Publication date: September 25, 2014
    Applicant: Amgen Inc.
    Inventors: Mingyue Zhou, Wenyan Shen, Bei Shan, Margrit Schwarz, David Park Meininger, Tom Boone
  • Modified lecithin-cholesterol acyltransferase enzymes
    Patent number: 8703926
    Abstract: The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: April 22, 2014
    Assignee: Amgen Inc.
    Inventors: Mingyue Zhou, Wenyan Shen, Bei Shan, Margrit Schwarz, David Park Meininger, Tom Boone
  • Modified lecithin-cholesterol acyltransferase enzymes
    Patent number: 8168416
    Abstract: The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: May 1, 2012
    Assignee: Amgen Inc.
    Inventors: Tom Boone, David Park Meininger, Margrit Schwarz, Bei Shan, Wenyan Shen, Mingyue Zhou
  • Substituted biphenyl GPR40 modulators
    Patent number: 8030354
    Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: October 4, 2011
    Assignee: Amgen Inc.
    Inventors: Sean P. Brown, Qiong Cao, Paul John Dransfield, Xiaohui Du, Zice Fu, Jonathan Houze, Xian Yun Jiao, Yong-Jae Kim, Todd J. Kohn, SuJen Lai, An-Rong Li, Daniel Lin, Jiwen Liu, Jian Luo, Julio C. Medina, Jeffrey D. Reagan, Vatee Pattaropong, Margrit Schwarz, Wang Shen, Yongli Su, Gayathri Swaminath, Marc Vimolratana, Yingcai Wang, Yumei Xiong, Li Yang, Ming Yu, Jie Zhang, Liusheng Zhu
  • Substituted biphenyl GPR40 modulators
    Publication number: 20090137561
    Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
    Type: Application
    Filed: October 3, 2008
    Publication date: May 28, 2009
    Applicant: Amgen Inc.
    Inventors: Sean P. Brown, Qiong Cao, Paul John Dransfield, Xiaohui Du, Jonathan Houze, Xian Yun Jiao, Yong-Jae Kim, Todd J. Kohn, SuJen Lai, An-Rong Li, Daniel Lin, Jian Luo, Julio C. Medina, Jeffrey D. Reagan, Vatee Pattaropong, Margrit Schwarz, Wang Shen, Yongli Su, Gayathri Swaminath, Marc Vimolratana, Xiang Wang, Yumei Xiong, Li Yang, Ming Yu, Jie Zhang, Liusheng Zhu
  • Modified Lecithin-Cholesterol Acyltransferase Enzymes
    Publication number: 20090081182
    Abstract: The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.
    Type: Application
    Filed: July 25, 2008
    Publication date: March 26, 2009
    Applicant: AMGEN INC.
    Inventors: Tom BOONE, David P. MEININGER, Margrit SCHWARZ, Bei SHAN, Wenyan SHEN, Mingyue ZHOU