Patents by Inventor Marguerita S. Lim-Wilby

Marguerita S. Lim-Wilby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors (II)
    Patent number: 6204384
    Abstract: The present invention provides peptide aldehydes having an 3-amino-2-hydro yenyl acetamide group as part of the peptide backbone d an arginine group or analog at P1. These compounds e potent and specific or inhibitors of thrombin. Ther pharmaceutically acceptable salts, pharmaceutic ly acceptable compositions thereof, and methods of using t as therapeutic agents for disease states in mammals charachterized by abnormal thrombosis are also described. Also described are 3-amino-2-hydroxyphenyl-acetamide derivatives having in history activity towards proteases of the trypsin/chymotrypsin class.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: March 20, 2001
    Assignee: Corvas International, Inc.
    Inventors: Joseph Edward Semple, Marguerita S. Lim-Wilby, Terence K. Brunck
  • Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors
    Patent number: 6011047
    Abstract: The present invention provides peptide aldehydes having a 3-amino-2-hydroxyphyenyl-acetamide group as part of the peptide backbone and an arginine mimic group such as an amidinopiperidine or amidinophenyl tail. These compounds are potent and specific inhibitors of thrombin. Their pharmaceutically salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis are also described. Also described are 3-amino-2-hydroxyphenyl-acetamide derivatives having inhibitory activity toward proteases of the trypsin/chymotrypsin class.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: January 4, 2000
    Assignee: Corvas International Inc.
    Inventors: Joseph Edward Semple, Marguerita S. Lim-Wilby, Terence K. Brunck