Abstract: The invention includes compositions and methods useful for the diagnosis, prognosis, treatment, assessment, and characterization of inflammation or pain (e.g., neuropathic pain) in a subject in need thereof, based upon the expression level of at least one miRNA that is associated with inflammation or pain. In one aspect, the invention relates to compositions and methods for the prediction of a subject's responsiveness of a treatment of inflammation or pain.

Abstract: A surgical method of corneal reformation with multiple surgical instruments. Surgical instruments include the optional use of vibration with an epithelial separator or cannula to separate an epithelial sheet from the cornea of no more than about 85 microns thick. The surgical method of corneal reformation reduces the risk of trauma and shortens overall recovery while yielding improved visual acuity. The method comprises making a relatively shallow incision of no more than about 85 microns deep into the corneal epithelium, separating the corneal epithelial sheet from the underlying Bowman's Membrane using an epithelial separator or a specialized cannula, and lifting the epithelial sheet away from the ablation zone so that the Bowman's Membrane and underlying stromal bed can be reformed.

Abstract: Multiple surgical instruments for use with a surgical method of corneal reformation. Surgical instruments include the optional use of vibration with an epithelial separator or cannula to separate an epithelial sheet from the cornea of no more than about 85 microns thick. The surgical method of corneal reformation reduces the risk of trauma and shortens overall recovery while yielding improved visual acuity. The method comprises making a relatively shallow incision of no more than about 85 microns deep into the corneal epithelium, separating the corneal epithelial sheet from the underlying Bowman's Membrane using an epithelial separator or a specialized cannula, and lifting the epithelial sheet away from the ablation zone so that the Bowman's Membrane and underlying stromal bed can be reformed.

Abstract: Multiple surgical instruments for use with a surgical method of corneal reformation. Surgical instruments include the optional use of vibration with an epithelial separator or cannula to separate an epithelial sheet from the cornea of no more than about 85 microns thick. The surgical method of corneal reformation reduces the risk of trauma and shortens overall recovery while yielding improved visual acuity. The method comprises making a relatively shallow incision of no more than about 85 microns deep into the corneal epithelium, separating the corneal epithelial sheet from the underlying Bowman's Membrane using an epithelial separator or a specialized cannula, and lifting the epithelial sheet away from the ablation zone so that the Bowman's Membrane and underlying stromal bed can be reformed.

Abstract: In accordance with the present invention, a multifocal intraocular lens provides greater or lesser refraction in relation to the position of the head and eyes of a user. A multifocal intraocular lens body for insertion into a fluid-filled enucleated natural lens capsule of an eye is provided wherein the lens body encompasses the optical axis of the eye and provides different greater or lesser refraction depending upon the position of the eye.

Abstract: In accordance with the present invention, a multifocal intraocular lens provides greater or lesser refraction in relation to the position of the head and eyes of a user. A multifocal intraocular lens body for insertion into a fluid-filled enucleated natural lens capsule of an eye is provided wherein the lens body encompasses the optical axis of the eye and provides different greater or lesser refraction depending upon the position of the eye. In a second embodiment, the lens body can be used with an artificial lens capsule implanted within an eye.