Patents by Inventor Margus Eek

Margus Eek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of O-demethylation
    Patent number: 11136331
    Abstract: There is provided a novel process for the preparation of a compound of formula I, wherein R1, R2, W, Z and are as described in the description, by demethylation of a corresponding O-methyl derivative with a borohydride-based reagent. This process may be used in the preparation of buprenorphine.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: October 5, 2021
    Assignee: CAMBREX CHARLES CITY, INC.
    Inventors: Par Holmberg, Lars Eklund, David Adams, Michael Letourneau, Margus Eek, Alo Soone
  • NEW PROCESS
    Publication number: 20210188862
    Abstract: There is provided a novel process for the preparation of a compound of formula I, wherein R1, R2, W, Z and are as described in the description, by demethylation of a corresponding O-methyl derivative with a borohydride-based reagent. This process may be used in the preparation of buprenorphine.
    Type: Application
    Filed: October 12, 2018
    Publication date: June 24, 2021
    Inventors: Par HOLMBERG, Lars EKLUND, David ADAMS, Michael LETOURNEAU, Margus EEK, Alo SOONE
  • Processes for the preparation of compounds, such as 3-arylbutanals, useful in the synthesis of medetomidine
    Patent number: 10053420
    Abstract: There is provided a process for the preparation of a compound of formula (I) as defined herein, wherein said process comprises reacting a compound of formula (II) as defined s herein with one or more suitable Vilsmeier reagent.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: August 21, 2018
    Assignee: Cambrex Karlskoga AB
    Inventors: Lars Eklund, Margus Eek, Ramesh Ekambaram, Ants Maasalu
  • PROCESSES FOR THE PREPARATION OF COMPOUNDS, SUCH AS 3-ARYLBUTANALS, USEFUL IN THE SYNTHESIS OF MEDETOMIDINE
    Publication number: 20180009744
    Abstract: There is provided a process for the preparation of a compound of formula (I) as defined herein, wherein said process comprises reacting a compound of formula (II) as defined s herein with one or more suitable Vilsmeier reagent.
    Type: Application
    Filed: January 29, 2016
    Publication date: January 11, 2018
    Applicant: Cambrex Karlskoga AB
    Inventors: Lars Eklund, Margus Eek, Ramesh Ekambaram, Ants Maasalu
  • Process for preparing lacosamide and related compounds
    Patent number: 9771317
    Abstract: There is provided a process for the preparation of Lacosamide in a particular polymorphic form, which process involves the isolation of a salt of formula I: according to the methods defined in the application.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: September 26, 2017
    Assignees: Cambrex Karlskoga AB, Cambrex Profarmaco Milano
    Inventors: Stefano Radaelli, Giuseppe Zurlo, Lars Eklund, Margus Eek, Ants Maasalu, Malle Schmidt
  • NEW PROCESS
    Publication number: 20150299105
    Abstract: There is provided a process for the preparation of Lacosamide in a particular polymorphic form, which process involves the isolation of a salt of formula I: according to the methods defined in the application.
    Type: Application
    Filed: November 1, 2013
    Publication date: October 22, 2015
    Inventors: Stefano RADAELLI, Giuseppe ZURLO, Lars EKLUND, Margus EEK, Ants MAASALU, Malle SCHMIDT
  • Processes for preparing 4-substituted imidazoles
    Patent number: 8962862
    Abstract: There is provided a novel process for the preparation of a compound of formula (I), (Formula (I)). There is also provided novel processes to intermediates of the compound of formula (I), as well as novel intermediates themselves.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: February 24, 2015
    Assignee: Cambrex Karlskoga AB
    Inventors: Lars Eklund, Lars Hansson, Tommy Lundholm, Pär Holmberg, Margus Eek
  • NEW PROCESSES FOR PREPARING 4-SUBSTITUTED IMIDAZOLES
    Publication number: 20140187789
    Abstract: There is provided a novel process for the preparation of a compound of formula (I), (Formula (I)). There is also provided novel processes to intermediates of the compound of formula (I), as well as novel intermediates themselves.
    Type: Application
    Filed: July 20, 2012
    Publication date: July 3, 2014
    Applicant: CAMBREX KARLSKOGA AB
    Inventors: Lars Eklund, Lars Hansson, Tommy Lundholm, Pär Holmberg, Margus Eek
  • PROCESS FOR THE PREPARATION OF LACOSAMIDE
    Publication number: 20130317109
    Abstract: There is provided a process for the preparation of Lacosamide (which is a useful medicament) of formula I, which comprises an enantioselective enzymatic acylation.
    Type: Application
    Filed: November 25, 2011
    Publication date: November 28, 2013
    Applicant: CAMBREX KARLSKOGA AB
    Inventors: Cecilia Kvarnström Branneby, Margus Eek
  • Esters of (2-hydroxy-3-oxo-cyclopent-1-enyl) acetic acid and their use for preparing (?)--homocitric acid gamma-lactone, (+)--homocitric acid gamma-lactone and the corresponding (?)--homocitric acid and (+)--homocitric acid salts
    Patent number: 8148568
    Abstract: Archiral (2-hydroxy-3-oxo-cyclopent-1-enyl) acetic acid) alkyl, alkylphenyl and phenyl esters, and a simple and efficient method for the synthesis of both enantiomers of homocitric acid gamma-lactone and the corresponding salts from these esters are described. The method is based on asymmetric oxidation of esters, and the steps of basic and acidic hydrolysis and final acidic lactonization of the homocitric acid into homocitric acid gamma-lactone. The homocitric acid salts are obtained after basic treatment of homocitric acid gamma-lactone. The esters, conditions and reagents used in chemical conversion and separating products are important constituents affording efficient and simple method for production of homocitric acid gamma-lactone and homocitric acid salts.
    Type: Grant
    Filed: May 25, 2007
    Date of Patent: April 3, 2012
    Assignees: Tallinn University of Technology, Cambrex Tallinn AS
    Inventors: Margus Lopp, Anne Paju, Margus Eek, Marit Laos, Tonis Pehk, Raissa Jaalaid
  • ESTERS OF (2-HYDROXY-3-OXO-CYCLOPENT-1-ENYL) ACETIC ACID AND THEIR USE FOR PREPARING (-)-R-HOMOCITRIC ACID GAMMA-LACTONE, (+)-S-HOMOCITRIC ACID GAMMA-LACTONE AND THE CORRESPONDING (-)-R-HOMOCITRIC ACID AND (+)-S-HOMOCITRIC ACID SALTS
    Publication number: 20090187041
    Abstract: Archiral (2-hydroxy-3-oxo-cyclopent-1-enyl) acetic acid) alkyl, alkylphenyl and phenyl esters, and a simple and efficient method for the synthesis of both enantiomers of homocitric acid gamma-lactone and the corresponding salts from these esters are described. The method is based on asymmetric oxidation of esters, and the steps of basic and acidic hydrolysis and final acidic lactonization of the homocitric acid into homocitric acid gamma-lactone. The homocitric acid salts are obtained after basic treatment of homocitric acid gamma-lactone. The esters, conditions and reagents used in chemical conversion and separating products are important constituents affording efficient and simple method for production of homocitric acid gamma-lactone and homocitric acid salts.
    Type: Application
    Filed: May 25, 2007
    Publication date: July 23, 2009
    Applicants: Tallinn University of Technology, AS Vahiuuringute Tehnoloogia Arenduskeskus, Cambrex Tallinn AS
    Inventors: Margus Lopp, Anne Paju, Margus Eek, Marit Laos, Tõnis Pehk, Raissa Jäälaid